DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF600

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001308795.1	Gene:	ZNF600 / 162966	HGNCID:	30951	Length:	791	Species:	Homo sapiens

Alignment Length:	233	Identity:	78/233 - (33%)
Similarity:	112/233 - (48%)	Gaps:	35/233 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 TTKRHR---TTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTH 149
            |.:.|:   |..|.:.|.:||:.|:....|..|...|:.|||:.|.||.|.||..:.|..|...|
Human   525 TLETHKIIHTGEKPYKCKVCDKAFACHSYLAKHTRIHSGEKPYKCNECSKTFRLRSYLASHRRVH 589

  Fly   150 TAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSF-HS---IHARRIHTKLRHAA 210
            :.|:|:||:.|.|.|...:||..|||||:|||||.|  .:|..:| |.   :|.||:|
Human   590 SGEKPYKCNECSKTFSQRSYLHCHRRLHSGEKPYKC--NECGKTFSHKPSLVHHRRLH------- 645

  Fly   211 QTDPDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSA 275
                             |...|:.|.||.:......||:.|.:.|..::.:.|  .||||.|...
Human   646 -----------------TGEKSYKCTVCDKAFVRNSYLARHTRIHTAEKPYKC--NECGKAFNQQ 691

  Fly   276 SELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            |:|..|...|..::.:.|..|...|.|||:.|:|.::|
Human   692 SQLSLHHRIHAGEKLYKCETCDKVFSRKSHLKRHRRIH 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	6/19 (32%)
		zf-H2C2_2	113..138	CDD:290200	11/24 (46%)
		C2H2 Zn finger	129..149	CDD:275368	8/19 (42%)
		zf-H2C2_2	142..166	CDD:290200	10/23 (43%)
		COG5048	151..>264	CDD:227381	36/116 (31%)
		C2H2 Zn finger	157..177	CDD:275368	9/19 (47%)
		C2H2 Zn finger	185..206	CDD:275368	8/24 (33%)
		C2H2 Zn finger	235..255	CDD:275368	6/19 (32%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	8/19 (42%)
ZNF600	NP_001308795.1	KRAB	24..71	CDD:214630
		KRAB	24..60	CDD:279668
		COG5048	<154..503	CDD:227381
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	261..281	CDD:275368
		zf-H2C2_2	273..298	CDD:290200
		C2H2 Zn finger	289..309	CDD:275368
		C2H2 Zn finger	317..337	CDD:275368
		zf-H2C2_2	329..354	CDD:290200
		COG5048	341..748	CDD:227381	78/233 (33%)
		C2H2 Zn finger	345..365	CDD:275368
		zf-H2C2_2	357..382	CDD:290200
		C2H2 Zn finger	373..393	CDD:275368
		zf-H2C2_2	386..409	CDD:290200
		C2H2 Zn finger	401..421	CDD:275368
		zf-H2C2_2	414..438	CDD:290200
		C2H2 Zn finger	429..449	CDD:275368
		C2H2 Zn finger	457..477	CDD:275368
		C2H2 Zn finger	485..505	CDD:275368
		C2H2 Zn finger	513..533	CDD:275368	2/7 (29%)
		zf-H2C2_2	526..550	CDD:290200	7/23 (30%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		C2H2 Zn finger	569..589	CDD:275368	8/19 (42%)
		zf-H2C2_2	581..606	CDD:290200	10/24 (42%)
		C2H2 Zn finger	597..617	CDD:275368	9/19 (47%)
		C2H2 Zn finger	625..645	CDD:275368	7/21 (33%)
		C2H2 Zn finger	653..673	CDD:275368	6/19 (32%)
		zf-H2C2_2	665..690	CDD:290200	10/26 (38%)
		C2H2 Zn finger	681..701	CDD:275368	9/21 (43%)
		zf-C2H2	707..729	CDD:278523	8/21 (38%)
		C2H2 Zn finger	709..729	CDD:275368	8/19 (42%)
		zf-H2C2_2	721..744	CDD:290200	3/9 (33%)
		C2H2 Zn finger	737..757	CDD:275368
		zf-H2C2_2	749..773	CDD:290200
		C2H2 Zn finger	765..785	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000