DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF836

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001096127.1	Gene:	ZNF836 / 162962	HGNCID:	34333	Length:	936	Species:	Homo sapiens

Alignment Length:	233	Identity:	83/233 - (35%)
Similarity:	124/233 - (53%)	Gaps:	10/233 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 KRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERP 154
            :|..|..|.:.|:.|.:.||::|||.||:..||.|||:.|.||||.|:|.:.|..|.:.||.|:|
Human   293 RRSHTGEKPYKCNECGKSFSQSYNLAIHQRIHTGEKPYKCNECGKTFKQGSCLTTHQIIHTGEKP 357

  Fly   155 HKCDICGKGFRYANYLTVHRRLHTGEKPYPC------LATDCHLSFH-SIHARRIHTKLRHAAQT 212
            ::||||||.||..:.|..|:|:|||||||.|      .:...:|:.| ::|:.....|.....:|
Human   358 YQCDICGKVFRQNSNLVNHQRIHTGEKPYKCNICGKSFSQSSNLATHQTVHSGNKPYKCDECGKT 422

  Fly   213 DPDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASE 277
            . .....|...:...|....:||.||.:|.:.:..|:.|.:.|..::.:.|  .||||.|...|.
Human   423 F-KRSSSLTTHQIIHTGEKPYTCDVCDKVFSQRSQLARHQRSHTGEKPYKC--NECGKVFSQTSH 484

  Fly   278 LKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVHER 315
            |..|:..||.::|:.|..|...|.:.|...:|..:|.|
Human   485 LVGHRRIHTGEKPYKCDKCGKAFKQGSLLTRHKIIHTR 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	9/19 (47%)
		zf-H2C2_2	113..138	CDD:290200	15/24 (63%)
		C2H2 Zn finger	129..149	CDD:275368	9/19 (47%)
		zf-H2C2_2	142..166	CDD:290200	13/23 (57%)
		COG5048	151..>264	CDD:227381	36/119 (30%)
		C2H2 Zn finger	157..177	CDD:275368	11/19 (58%)
		C2H2 Zn finger	185..206	CDD:275368	4/27 (15%)
		C2H2 Zn finger	235..255	CDD:275368	6/19 (32%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
ZNF836	NP_001096127.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	220..240	CDD:275368
		C2H2 Zn finger	248..268	CDD:275368
		COG5048	272..648	CDD:227381	83/233 (36%)
		C2H2 Zn finger	276..296	CDD:275368	1/2 (50%)
		zf-H2C2_2	288..313	CDD:290200	6/19 (32%)
		C2H2 Zn finger	304..324	CDD:275368	9/19 (47%)
		zf-H2C2_2	316..341	CDD:290200	15/24 (63%)
		C2H2 Zn finger	332..352	CDD:275368	9/19 (47%)
		zf-H2C2_2	345..369	CDD:290200	13/23 (57%)
		C2H2 Zn finger	360..380	CDD:275368	11/19 (58%)
		zf-H2C2_2	372..397	CDD:290200	11/24 (46%)
		C2H2 Zn finger	388..408	CDD:275368	3/19 (16%)
		zf-H2C2_2	400..425	CDD:290200	5/25 (20%)
		C2H2 Zn finger	416..436	CDD:275368	2/20 (10%)
		zf-H2C2_2	428..453	CDD:290200	7/24 (29%)
		C2H2 Zn finger	444..464	CDD:275368	6/19 (32%)
		zf-H2C2_2	457..481	CDD:290200	9/25 (36%)
		C2H2 Zn finger	472..492	CDD:275368	9/21 (43%)
		zf-H2C2_2	484..509	CDD:290200	8/24 (33%)
		COG5048	496..904	CDD:227381	8/27 (30%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		C2H2 Zn finger	528..548	CDD:275368
		zf-H2C2_2	541..565	CDD:290200
		C2H2 Zn finger	556..576	CDD:275368
		zf-H2C2_2	568..593	CDD:290200
		C2H2 Zn finger	584..604	CDD:275368
		zf-H2C2_2	597..620	CDD:290200
		C2H2 Zn finger	612..632	CDD:275368
		zf-H2C2_2	624..649	CDD:290200
		C2H2 Zn finger	640..660	CDD:275368
		zf-H2C2_2	653..677	CDD:290200
		C2H2 Zn finger	668..688	CDD:275368
		C2H2 Zn finger	696..714	CDD:275370
		C2H2 Zn finger	724..744	CDD:275368
		C2H2 Zn finger	752..772	CDD:275368
		zf-H2C2_2	764..789	CDD:290200
		C2H2 Zn finger	780..800	CDD:275368
		zf-H2C2_2	793..815	CDD:290200
		C2H2 Zn finger	808..828	CDD:275368
		zf-H2C2_2	821..843	CDD:290200
		C2H2 Zn finger	836..856	CDD:275368
		zf-H2C2_2	849..873	CDD:290200
		C2H2 Zn finger	864..884	CDD:275368
		zf-H2C2_2	877..899	CDD:290200
		C2H2 Zn finger	892..912	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910