DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2120 and ZNF543

DIOPT Version :9

Sequence 1:NP_572446.2 Gene:CG2120 / 31737 FlyBaseID:FBgn0030005 Length:315 Species:Drosophila melanogaster
Sequence 2:NP_998763.2 Gene:ZNF543 / 125919 HGNCID:25281 Length:600 Species:Homo sapiens


Alignment Length:299 Identity:91/299 - (30%)
Similarity:136/299 - (45%) Gaps:49/299 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 LEDLSGER--------LPMEMELLNPGSEYDLLEL-----VNGALQQRNTTEHKPTDMCKP-KRT 86
            ||.:|.||        :..::......:|.||.|.     |..||.:.....:|..:..|. |:.
Human   147 LEKMSSERDGLGSDDGVCTKITQKQVSTEGDLYECDSHGPVTDALIREEKNSYKCEECGKVFKKN 211

  Fly    87 PTTKRH---RTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVT 148
            ....:|   .|..|.:.|..|.:.||::.:|..|.:.||.|||:.|:||||.|.:.:.|..|...
Human   212 ALLVQHERIHTQVKPYECTECGKTFSKSTHLLQHLIIHTGEKPYKCMECGKAFNRRSHLTRHQRI 276

  Fly   149 HTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHS----IHARRIHTKLRHA 209
            |:.|:|:||..|||.|.:.:...:|.|.||||||:.|  .:|..:|..    |....|||     
Human   277 HSGEKPYKCSECGKAFTHRSTFVLHHRSHTGEKPFVC--KECGKAFRDRPGFIRHYIIHT----- 334

  Fly   210 AQTDPDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFS 274
                  .|.|             :.|..|.:....:.||:.|.:.|...:.|.|  .||||.|..
Human   335 ------GEKP-------------YECIECGKAFNRRSYLTWHQQIHTGVKPFEC--NECGKAFCE 378

  Fly   275 ASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            :::|..|.|.||.::|:.|..|...|.|:|:.|||.::|
Human   379 SADLIQHYIIHTGEKPYKCMECGKAFNRRSHLKQHQRIH 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2120NP_572446.2 C2H2 Zn finger 101..121 CDD:275368 6/19 (32%)
zf-H2C2_2 113..138 CDD:290200 13/24 (54%)
C2H2 Zn finger 129..149 CDD:275368 8/19 (42%)
zf-H2C2_2 142..166 CDD:290200 11/23 (48%)
COG5048 151..>264 CDD:227381 32/116 (28%)
C2H2 Zn finger 157..177 CDD:275368 7/19 (37%)
C2H2 Zn finger 185..206 CDD:275368 7/24 (29%)
C2H2 Zn finger 235..255 CDD:275368 5/19 (26%)
C2H2 Zn finger 263..285 CDD:275368 9/21 (43%)
C2H2 Zn finger 293..313 CDD:275368 8/19 (42%)
ZNF543NP_998763.2 KRAB 9..69 CDD:214630
COG5048 <75..329 CDD:227381 58/183 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..131
C2H2 Zn finger 201..221 CDD:275368 3/19 (16%)
COG5048 223..562 CDD:227381 74/223 (33%)
C2H2 Zn finger 229..249 CDD:275368 6/19 (32%)
C2H2 Zn finger 257..277 CDD:275368 8/19 (42%)
C2H2 Zn finger 285..305 CDD:275368 7/19 (37%)
C2H2 Zn finger 313..333 CDD:275368 4/21 (19%)
C2H2 Zn finger 341..361 CDD:275368 5/19 (26%)
C2H2 Zn finger 369..389 CDD:275368 9/21 (43%)
C2H2 Zn finger 397..417 CDD:275368 8/19 (42%)
C2H2 Zn finger 425..445 CDD:275368
C2H2 Zn finger 453..473 CDD:275368
C2H2 Zn finger 481..501 CDD:275368
C2H2 Zn finger 509..529 CDD:275368
C2H2 Zn finger 537..557 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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