DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF660-ZNF197

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001338661.1	Gene:	ZNF660-ZNF197 / 110354863	-ID:	-	Length:	1029	Species:	Homo sapiens

Alignment Length:	317	Identity:	99/317 - (31%)
Similarity:	136/317 - (42%)	Gaps:	72/317 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 ALQQRNTTEH-----KPTDMC---KPKRTPTTKRHR---------------------TTGKD-HT 100
            |.|..|.|:.     |...:|   |.||||..|:.:                     |.||. :.
Human   307 ASQWGNETDERADTVKKVSLCERDKKKRTPPEKQGQKWKELGDSLTFGSAISESLIGTEGKKFYK 371

  Fly   101 CDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERPHKCDICGKGFR 165
            ||:|.:.|::..:|..|:..||.||||.|.||||||.|.:.|.:|...|:.|:|:||:.|||.|.
Human   372 CDMCCKHFNKISHLINHRRIHTGEKPHKCKECGKGFIQRSSLLMHLRNHSGEKPYKCNECGKAFS 436

  Fly   166 YANYLTVHRRLHTGEKPYPCLATDCHLSF--HS---IHARRIHTKLR-------------HAAQT 212
            .:.||..|:|:|||||||.|  .:|...|  ||   ||.|| |:..|             :|...
Human   437 QSAYLLNHQRIHTGEKPYKC--KECGKGFYRHSGLIIHLRR-HSGERPYKCNECGKVFSQNAYLI 498

  Fly   213 DPDPEH-------------------PLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQ 258
            |....|                   .|...::..:....:.|..|.:......||..|.:.|..:
Human   499 DHQRLHKGEEPYKCNKCQKAFILKKSLILHQRIHSGEKPYKCDECGKTFAQTTYLIDHQRLHSAE 563

  Fly   259 RDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVHER 315
            ..:.|  .||||.|..:..|..||..||:::.|.|..|...|..|||...|.::|.|
Human   564 NPYKC--KECGKVFIRSKSLLLHQRVHTEKKTFGCKKCGKIFSSKSNFIDHKRMHSR 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	6/19 (32%)
		zf-H2C2_2	113..138	CDD:290200	15/24 (63%)
		C2H2 Zn finger	129..149	CDD:275368	10/19 (53%)
		zf-H2C2_2	142..166	CDD:290200	11/23 (48%)
		COG5048	151..>264	CDD:227381	40/149 (27%)
		C2H2 Zn finger	157..177	CDD:275368	9/19 (47%)
		C2H2 Zn finger	185..206	CDD:275368	10/25 (40%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
ZNF660-ZNF197	NP_001338661.1	SCAN	38..150	CDD:128708
		KRAB	216..256	CDD:307490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..290
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		zf-H2C2_2	384..409	CDD:316026	15/24 (63%)
		C2H2 Zn finger	400..420	CDD:275368	10/19 (53%)
		COG5048	424..853	CDD:227381	60/200 (30%)
		C2H2 Zn finger	428..448	CDD:275368	9/19 (47%)
		C2H2 Zn finger	456..476	CDD:275368	9/22 (41%)
		C2H2 Zn finger	484..504	CDD:275368	2/19 (11%)
		C2H2 Zn finger	512..532	CDD:275368	1/19 (5%)
		C2H2 Zn finger	540..560	CDD:275368	5/19 (26%)
		C2H2 Zn finger	568..588	CDD:275368	9/21 (43%)
		C2H2 Zn finger	596..616	CDD:275368	7/19 (37%)
		C2H2 Zn finger	624..644	CDD:275368
		C2H2 Zn finger	652..672	CDD:275368
		C2H2 Zn finger	680..700	CDD:275368
		C2H2 Zn finger	708..728	CDD:275368
		C2H2 Zn finger	736..756	CDD:275368
		COG5048	760..>1026	CDD:227381
		C2H2 Zn finger	764..784	CDD:275368
		C2H2 Zn finger	792..812	CDD:275368
		C2H2 Zn finger	820..840	CDD:275368
		C2H2 Zn finger	848..868	CDD:275368
		C2H2 Zn finger	876..896	CDD:275368
		C2H2 Zn finger	904..924	CDD:275368
		C2H2 Zn finger	932..952	CDD:275368
		C2H2 Zn finger	960..980	CDD:275368
		C2H2 Zn finger	988..1008	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000