DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF234

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001138296.1	Gene:	ZNF234 / 10780	HGNCID:	13027	Length:	700	Species:	Homo sapiens

Alignment Length:	252	Identity:	90/252 - (35%)
Similarity:	127/252 - (50%)	Gaps:	31/252 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 QRNTTEHKP--TDMCKP--KRTPTTKRH---RTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKP 126
            ||..|..||  .|.|..  :|......|   .|..|.:.|:.|.:.|:.:.|||||:..||.|||
Human   279 QRIHTGEKPFKCDTCGKNFRRRSALNNHCMVHTGEKPYKCEDCGKCFTCSSNLRIHQRVHTGEKP 343

  Fly   127 HVCVECGKGFRQLNKLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCH 191
            :.|.||||.|.|.::.:.|...||.|:|:.|.:|||||.|::....|:.:|||||||.|  .:|.
Human   344 YKCEECGKCFIQPSQFQAHRRIHTGEKPYVCKVCGKGFIYSSSFQAHQGVHTGEKPYKC--NECG 406

  Fly   192 LSFHSIHARRIHTKLRHAAQTDPDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHY 256
            .||.    .:||.::.....|...|                :.|.||.:......||.||||.|.
Human   407 KSFR----MKIHYQVHLVVHTGEKP----------------YKCEVCGKAFRQSSYLKIHLKAHS 451

  Fly   257 NQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            .|:.|.|  .|||:.|..:|.|:.||:.||.::|:.|..|...|.|:::.|.|.::|
Human   452 VQKPFKC--EECGQGFNQSSRLQIHQLIHTGEKPYKCEECGKGFSRRADLKIHCRIH 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	8/19 (42%)
		zf-H2C2_2	113..138	CDD:290200	16/24 (67%)
		C2H2 Zn finger	129..149	CDD:275368	8/19 (42%)
		zf-H2C2_2	142..166	CDD:290200	11/23 (48%)
		COG5048	151..>264	CDD:227381	37/112 (33%)
		C2H2 Zn finger	157..177	CDD:275368	8/19 (42%)
		C2H2 Zn finger	185..206	CDD:275368	6/20 (30%)
		C2H2 Zn finger	235..255	CDD:275368	9/19 (47%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
ZNF234	NP_001138296.1	KRAB	8..65	CDD:214630
		KRAB	8..47	CDD:279668
		KRNB	91..147
		COG5048	<101..306	CDD:227381	8/26 (31%)
		C2H2 Zn finger	150..170	CDD:275368
		C2H2 Zn finger	178..198	CDD:275368
		zf-C2H2	204..226	CDD:278523
		C2H2 Zn finger	206..226	CDD:275368
		zf-H2C2_2	218..243	CDD:290200
		C2H2 Zn finger	234..254	CDD:275368
		COG5048	258..672	CDD:227381	90/252 (36%)
		C2H2 Zn finger	262..282	CDD:275368	2/2 (100%)
		zf-H2C2_2	274..299	CDD:290200	7/19 (37%)
		C2H2 Zn finger	290..310	CDD:275368	4/19 (21%)
		C2H2 Zn finger	318..338	CDD:275368	8/19 (42%)
		zf-H2C2_2	330..355	CDD:290200	16/24 (67%)
		C2H2 Zn finger	346..366	CDD:275368	8/19 (42%)
		zf-H2C2_2	359..383	CDD:290200	11/23 (48%)
		C2H2 Zn finger	374..394	CDD:275368	8/19 (42%)
		C2H2 Zn finger	402..422	CDD:275368	6/25 (24%)
		zf-H2C2_2	414..439	CDD:290200	6/40 (15%)
		C2H2 Zn finger	430..450	CDD:275368	9/19 (47%)
		C2H2 Zn finger	458..478	CDD:275368	9/21 (43%)
		zf-H2C2_2	471..495	CDD:290200	9/23 (39%)
		C2H2 Zn finger	486..506	CDD:275368	6/19 (32%)
		zf-H2C2_2	498..523	CDD:290200	3/9 (33%)
		C2H2 Zn finger	514..534	CDD:275368
		zf-H2C2_2	526..551	CDD:290200
		C2H2 Zn finger	542..562	CDD:275368
		zf-H2C2_2	554..578	CDD:290200
		C2H2 Zn finger	570..590	CDD:275368
		zf-H2C2_2	582..607	CDD:290200
		C2H2 Zn finger	598..618	CDD:275368
		zf-H2C2_2	610..635	CDD:290200
		C2H2 Zn finger	626..646	CDD:275368
		zf-H2C2_2	639..662	CDD:290200
		C2H2 Zn finger	654..674	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910