DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF605

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001158187.1	Gene:	ZNF605 / 100289635	HGNCID:	28068	Length:	672	Species:	Homo sapiens

Alignment Length:	303	Identity:	92/303 - (30%)
Similarity:	130/303 - (42%)	Gaps:	69/303 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SGER-LPMEMELLNPGSEYDLLELVNGALQQRNTTEHKPTD-------MC-KPKRTP-------- 87
            :||: |....:||.|                :|..|.|..|       .| ||.||.
Human   128 TGEKSLKCPFDLLIP----------------KNNCERKKIDELNKKLLFCIKPGRTHGGIKYCDC 176

  Fly    88 ------------TTKRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLN 140
                        .|..|.|....:.|..|.|.|::...|.||:.|||.|||:.|.||||.|.|.:
Human   177 STCRKSSNEEPWLTANHITHTGVYLCMECGRFFNKKSQLVIHQRTHTGEKPYQCSECGKAFSQKS 241

  Fly   141 KLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHSIHARRIHTK 205
            .|.:|..||:.|:||.|..|.|.|...:.|.:|:|:|||||||.|  ::|..:|    :|:...|
Human   242 LLTVHQRTHSGEKPHGCSECQKAFSRKSLLILHQRIHTGEKPYGC--SECGKAF----SRKSQLK 300

  Fly   206 LRHAAQTDPDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGK 270
            ......|...|                ::|..|.:..:.:..|..|.:.|..::.:||  ..|||
Human   301 RHQITHTIEKP----------------YSCSECGKAFSQKLKLITHQRAHTGEKPYPC--SHCGK 347

  Fly   271 RFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            .||..|:|..||..||.::|:.|..|...|.|.|...:|.::|
Human   348 AFFWKSQLITHQRTHTGKKPYGCGECQKAFSRNSLLIRHQRIH 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	7/19 (37%)
		zf-H2C2_2	113..138	CDD:290200	15/24 (63%)
		C2H2 Zn finger	129..149	CDD:275368	9/19 (47%)
		zf-H2C2_2	142..166	CDD:290200	11/23 (48%)
		COG5048	151..>264	CDD:227381	30/112 (27%)
		C2H2 Zn finger	157..177	CDD:275368	7/19 (37%)
		C2H2 Zn finger	185..206	CDD:275368	4/20 (20%)
		C2H2 Zn finger	235..255	CDD:275368	4/19 (21%)
		C2H2 Zn finger	263..285	CDD:275368	10/21 (48%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
ZNF605	NP_001158187.1	C2H2 Zn finger	566..586	CDD:275368
		C2H2 Zn finger	594..614	CDD:275368
		zf-H2C2_2	607..631	CDD:290200
		zf-C2H2	620..642	CDD:278523
		C2H2 Zn finger	622..642	CDD:275368
		C2H2 Zn finger	650..670	CDD:275368
		KRAB	7..65	CDD:214630
		KRAB	7..45	CDD:279668
		C2H2 Zn finger	176..196	CDD:275368	2/19 (11%)
		COG5048	199..603	CDD:227381	74/216 (34%)
		C2H2 Zn finger	202..222	CDD:275368	7/19 (37%)
		zf-H2C2_2	215..239	CDD:290200	15/23 (65%)
		C2H2 Zn finger	230..250	CDD:275368	9/19 (47%)
		C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		C2H2 Zn finger	286..306	CDD:275368	5/25 (20%)
		zf-H2C2_2	299..323	CDD:290200	5/39 (13%)
		C2H2 Zn finger	314..334	CDD:275368	4/19 (21%)
		C2H2 Zn finger	342..362	CDD:275368	10/21 (48%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
		zf-H2C2_2	383..407	CDD:290200	2/8 (25%)
		C2H2 Zn finger	398..418	CDD:275368
		C2H2 Zn finger	426..446	CDD:275368
		C2H2 Zn finger	454..474	CDD:275368
		zf-H2C2_2	467..491	CDD:290200
		C2H2 Zn finger	482..502	CDD:275368
		zf-H2C2_2	494..518	CDD:290200
		C2H2 Zn finger	510..530	CDD:275368
		zf-H2C2_2	522..546	CDD:290200
		C2H2 Zn finger	538..558	CDD:275368
		zf-H2C2_2	551..575	CDD:290200
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000