DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and Gm14124

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001135882.1	Gene:	Gm14124 / 100216455	MGIID:	3652002	Length:	715	Species:	Mus musculus

Alignment Length:	230	Identity:	81/230 - (35%)
Similarity:	113/230 - (49%)	Gaps:	36/230 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 KRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERP 154
            ||..|..|.:.||.|.:.|:..|:|:.||..||.|||:.|.:|||.|...:|||.|..|||.|:|
Mouse   458 KRIHTGEKHYKCDQCGKDFASTYSLQNHKRVHTGEKPYECKQCGKAFACSSKLRSHKRTHTGEKP 522

  Fly   155 HKCDICGKGFRYANYLTVHRRLHTGEKPYPC------LATDCHLSFHSIHARRIHTKLRHAAQTD 213
            .:|:.|||.|...::|..|:|:|||||||.|      .|....|.:|    :|:||
Mouse   523 FECNQCGKSFAIKSHLLRHKRIHTGEKPYKCDQCGKDFARPSSLQYH----KRVHT--------- 574

  Fly   214 PDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASEL 278
              .|.|             :.|..|.:.......|.||.:.|..::.:.|.|  |||.|.|.|..
Mouse   575 --GEKP-------------YECKQCGKAFACSRRLRIHKRTHTGEKPYECNQ--CGKAFSSPSGF 622

  Fly   279 KHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            .:|:..||.:||:.|..|...|:.:||.:.|.:.|
Mouse   623 LYHKRTHTGERPYECNECGKSFIHRSNFQMHKRTH 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	8/19 (42%)
		zf-H2C2_2	113..138	CDD:290200	13/24 (54%)
		C2H2 Zn finger	129..149	CDD:275368	9/19 (47%)
		zf-H2C2_2	142..166	CDD:290200	13/23 (57%)
		COG5048	151..>264	CDD:227381	32/118 (27%)
		C2H2 Zn finger	157..177	CDD:275368	8/19 (42%)
		C2H2 Zn finger	185..206	CDD:275368	7/26 (27%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
Gm14124	NP_001135882.1	KRAB	4..>45	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	79..97	CDD:275368
		COG5048	87..514	CDD:227381	25/55 (45%)
		C2H2 Zn finger	105..125	CDD:275368
		zf-H2C2_2	117..142	CDD:290200
		C2H2 Zn finger	133..153	CDD:275368
		C2H2 Zn finger	161..181	CDD:275368
		C2H2 Zn finger	189..209	CDD:275368
		zf-H2C2_2	202..226	CDD:290200
		C2H2 Zn finger	217..237	CDD:275368
		C2H2 Zn finger	245..265	CDD:275368
		C2H2 Zn finger	273..293	CDD:275368
		C2H2 Zn finger	301..321	CDD:275368
		zf-H2C2_2	313..338	CDD:290200
		C2H2 Zn finger	329..349	CDD:275368
		zf-H2C2_2	341..366	CDD:290200
		C2H2 Zn finger	357..377	CDD:275368
		zf-H2C2_2	370..394	CDD:290200
		C2H2 Zn finger	385..405	CDD:275368
		zf-H2C2_2	397..422	CDD:290200
		C2H2 Zn finger	413..433	CDD:275368
		C2H2 Zn finger	441..461	CDD:275368	2/2 (100%)
		zf-H2C2_2	453..478	CDD:290200	8/19 (42%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		zf-H2C2_2	481..506	CDD:290200	13/24 (54%)
		C2H2 Zn finger	497..517	CDD:275368	9/19 (47%)
		zf-H2C2_2	510..533	CDD:290200	12/22 (55%)
		C2H2 Zn finger	525..545	CDD:275368	8/19 (42%)
		zf-H2C2_2	537..562	CDD:290200	11/24 (46%)
		C2H2 Zn finger	553..573	CDD:275368	5/23 (22%)
		zf-H2C2_2	565..590	CDD:290200	9/52 (17%)
		C2H2 Zn finger	581..601	CDD:275368	5/19 (26%)
		zf-H2C2_2	594..618	CDD:290200	10/25 (40%)
		C2H2 Zn finger	609..629	CDD:275368	9/21 (43%)
		C2H2 Zn finger	637..657	CDD:275368	6/19 (32%)
		zf-H2C2_2	649..674	CDD:290200	3/9 (33%)
		C2H2 Zn finger	665..685	CDD:275368
		zf-H2C2_2	677..702	CDD:290200
		C2H2 Zn finger	693..713	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000