DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10958 and Drc1

DIOPT Version :9

Sequence 1:	NP_572445.1	Gene:	CG10958 / 31736	FlyBaseID:	FBgn0030004	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001028632.1	Gene:	Drc1 / 381738	MGIID:	2685906	Length:	753	Species:	Mus musculus

Alignment Length:	761	Identity:	202/761 - (26%)
Similarity:	344/761 - (45%)	Gaps:	85/761 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EEEEVEPDLGPVDSWESFNDRIDGLIFNERCDKSVKKLDERRLAILNRVRQQFREA----PKGVA 82
            ||....|.|||                :...|...:::..|||.|..|...:.|||    ..|..
Mouse    15 EEHLATPILGP----------------SVHSDNPQERIQARRLRIAARQEARRREALGEYLDGKK 63

  Fly    83 ERCQAQKSPIDQRLELSSERLNELVRFGKELVTNVRVANERRELNRRLFEGAQKNQMHVKLQRES 147
            |..:.|.....|: |.|..:|.:|:..|.|||||::||.:.||::||:.|...|.|...||:.|.
Mouse    64 ESEEEQSKSYKQK-EESRLKLTKLLLCGTELVTNIQVAADVREIHRRVEEEETKRQRLEKLENEV 127

  Fly   148 VETMARFENIKARWTELEETNEPMLLWDQIEEQKKRIAEIMARKDEMISACQAEVDRMNAKYEFD 212
            ..:..:|:.|.|:|.|......|..||:.:..|:...||::..|:::.:..|.|:...:.:|..|
Mouse   128 KTSQDKFDEITAKWEEGRRKRIPQELWEMLNSQQVHCAELIEDKNKLANELQQELKIKDDQYVKD 192

  Fly   213 RERQAQDLCCLVERVDHQVETLKEAYKEHIQMLRQTIEEERQIFADNAVEKWRTFFDAMNANFDE 277
            .::|::|:..::||::.||:.:.:.:::.:..:.:..|.|||....:..:||.....|.||.
Mouse   193 LKKQSEDITLILERMEEQVKNVMKNFRQELIHIEKAFESERQELLSSNKKKWERALQAHNAK--- 254

  Fly   278 KANLVRAREQFYARQTQQINESQEELTK----------STRIRLEKECERLELELRRTRDNVLMN 332
                   ..::...:.:::.:.:::|.|          :.:|:||::.:.||.:|::.:....:|
Mouse   255 -------ELEYLTNRMKKVEDYEKQLNKQRVWDCEEYNTIKIKLEQDVQILEQQLQQMKATYQLN 312

  Fly   333 SEKLDYNYQVLQKRNEENVIINNQQKRRVARLHEAIGRTRRGLKNLYNTGKRNIARLSSDIYKLH 397
            .|||:||:|||:||:||:.:|.:||||::.|||:.:...|..........:.:...|:||..:|.
Mouse   313 QEKLEYNFQVLKKRDEESTVIKSQQKRKLNRLHDVVNNLRTKYTKQIRQFQDDNQSLTSDYKRLV 377

  Fly   398 SNINDMESKAHQARLNNREKFDRIWEINYKELNLLVDRVYHIDRIIHEQQLAMPWSSP------- 455
            :...|::.......:.:.|||..||.:|..|...|..|.:.:|||||.|.|.:||:.|
Mouse   378 TQFKDLQKALRHFIIIDEEKFREIWLMNEAEAKELAQRAFDVDRIIHSQHLGLPWNMPDLWFLNN 442

  Fly   456 VPPIPNINKAKKKRNNILEKFDMRIGRVPKNRVMPNSGVNCKPDIKELPPD-SLRLMRNLIRKLS 519
            |.||.  .:.:|....|||:..::.........|...     .|..:||.. |.:....::..|.
Mouse   443 VGPIS--LQQQKSVTQILEELLLQTEDEATEAAMSED-----EDYMDLPNQISAKTTTKVLMLLC 500

  Fly   520 DRGGFLIEERLLKILEPYSEEEKCLVRIDNIFAALRIRHLRDVKELTKVFMPYTYCPNCQPQGLS 584
            |..|||||.:||.:|.|..:.|..|:|:|.||:||.|....|:.:|...|:.|      :...||
Mouse   501 DESGFLIESKLLSLLHPLEKSECYLLRLDAIFSALAIEDEDDLYKLVNFFLRY------RAHRLS 559

  Fly   585 PRKCAEVFMKDQKPNRLQGA------------------AGGQPDEKEHRSTGD-TFLPKSEVAAK 630
            ..:.:.....:.:...|..|                  :..:|.|:|....|| ..|...|:..:
Mouse   560 SAQASSSIHSNVERTSLMSALERLSLMSQTDKGSMVSKSDQEPTEQEDEQEGDNASLSSRELEEQ 624

  Fly   631 RCHNHYLVMEPALCLHAMNLFTSKMHKKMYEHEPGSILNAVNLIQITDAEIRNFWRQFSACFPAS 695
            ...:....:.|...|..:..|.:.: ||..:.:|...|.........|.|   :|...:|..|..
Mouse   625 EDLSSPRFIHPNDVLKILEAFVTGL-KKPKDAQPVLKLKKETRDNSKDTE---YWESLAAVIPFF 685

  Fly   696 KCKLWKTLEHGLNHYVEVLKMRVQYDAEVVFLRRQNEELRHLLQKF 741
            |..||..|...|..|..||..|.:...|...|.:||.|::.|||::
Mouse   686 KQNLWDALYKALEKYYLVLTERAKLLMENESLEQQNAEMQSLLQQY 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10958	NP_572445.1	NYD-SP28	120..220	CDD:291438	28/99 (28%)
CG10958	NP_572445.1	NYD-SP28_assoc	684..741	CDD:291441	20/56 (36%)
Drc1	NP_001028632.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..76		3/20 (15%)
		NYD-SP28	100..200	CDD:291438	28/99 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..628		7/40 (18%)
		NYD-SP28_assoc	673..731	CDD:291441	21/60 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837962
Domainoid	1	1.000	165	1.000	Domainoid score	I3907
eggNOG	1	0.900	-	-		E1_2CMDT
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H35977
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3081
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56349
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008369
OrthoInspector	1	1.000	-	-		oto95241
orthoMCL	1	0.900	-	-		OOG6_104900
Panther	1	1.100	-	-	LDO	PTHR21625
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4490
SonicParanoid	1	1.000	-	-		X6353
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790