Protein Alignment CG10958 and Drc1

DIOPT Version :10

• Sequence 1: NP_572445.1
• Gene: CG10958 / 31736
• FlyBaseID: FBgn0030004
• Length: 743
• Species: Drosophila melanogaster
• Sequence 2: NP_001007010.1
• Gene: Drc1 / 362712
• RGDID: 1359318
• Length: 754
• Species: Rattus norvegicus
• Alignment Length: 750
• Identity: 208/750 - (27%)
• Similarity: 354/750 - (47%)
• Gaps: 62/750 - (8%)

  Fly    22 EEEEVEPDLGPVDSWESFNDRIDGLIFNERCDKSVKKLDERRLAILNRVRQQFREA----PKGVA 82
            ||....|.|||     |.|.           |...:::..|||.|..|...:.|||    ..|..
  Rat    15 EEHLAAPILGP-----SVNS-----------DNPQERIQARRLRIAARQEARRREALGEYLDGKK 63

  Fly    83 ERCQAQKSPIDQRLELSSERLNELVRFGKELVTNVRVANERRELNRRLFEGAQKNQMHVKLQRES 147
            |..:.|.....|: |.|..:|.:|:..|.|||||::||.:.||::||:.|...|.|...||:.|.
  Rat    64 ESEEEQSKSYKQK-EESRLKLTKLLLCGTELVTNIQVAADIREIHRRVEEEETKRQRLEKLENEV 127

  Fly   148 VETMARFENIKARWTELEETNEPMLLWDQIEEQKKRIAEIMARKDEMISACQAEVDRMNAKYEFD 212
            ..:..:|:.|.::|.|..:...|..||:.:..|:...|.::..|:::||..|.|:...:.:|..|
  Rat   128 KTSQDKFDEITSKWEEGRQKRIPQELWEMLNNQQVHCAGLVEDKNKLISELQQELKIKDDQYVKD 192

  Fly   213 RERQAQDLCCLVERVDHQVETLKEAYKEHIQMLRQTIEEERQIFADNAVEKWRTFFDAMNANFDE 277
            .::|::|:..|:||::.||:::.:.:::.:..:.:..|.|||.......:||.....|.||.  |
  Rat   193 LKKQSEDITVLLERMEEQVKSVMKNFRQELNYIEKAFESERQELLTTNKKKWERALQAHNAK--E 255

  Fly   278 KANLVR--AREQFYARQ--TQQINESQEELTKSTRIRLEKECERLELELRRTRDNVLMNSEKLDY 338
            ...|:.  .|.:.|.:|  .|::.:.:|  ..|.:|:||::.:.||.:|::.:....:|.|||:|
  Rat   256 LEYLINRMKRVEDYEKQLNRQRVWDCEE--YNSIKIKLEQDVQILEQQLQQMKATYQLNQEKLEY 318

  Fly   339 NYQVLQKRNEENVIINNQQKRRVARLHEAIGRTRRGLKNLYNTGKRNIARLSSDIYKLHSNINDM 403
            |:|||:||:||:.:|.:||||::.|||:.:...|..........:.:...|:||..:|.:...|:
  Rat   319 NFQVLKKRDEESTVIKSQQKRKLNRLHDILNNLRTKYSKQIKQFQEDNQSLTSDYKRLVTQFKDL 383

  Fly   404 ESKAHQARLNNREKFDRIWEINYKELNLLVDRVYHIDRIIHEQQLAMPWSSP-------VPPIPN 461
            :.......:.:::||..||.:|..|...|..|.:.:|:|||.|.|.:||..|       |.|| :
  Rat   384 QKAIRHFIIIDQDKFREIWLMNEAEAKELAQRAFDVDKIIHSQHLGLPWKIPNFWFLNNVGPI-S 447

  Fly   462 INKAKKKRNNILEKFDMRIGRVPKNRVMPNSGVNCKPDIKELPPD-SLRLMRNLIRKLSDRGGFL 525
            :.:.:|....|||:..::.........|...     ....:||.. |.:..:.::..|.|..|||
  Rat   448 LQQQQKSVTQILEELLLQSEDEGTETAMSED-----ESYMDLPNQVSAKTTKKILVLLCDESGFL 507

  Fly   526 IEERLLKILEPYSEEEKCLVRIDNIFAALRIRHLRDVKELTKVFMPYT--YCPNCQPQGLSPRKC 588
            ||.:||.:|.|..:.|..|:|:|.||:||.|....|:.::...|:.:.  :..:.| ..:|....
  Rat   508 IESKLLSLLLPLEKSECYLLRLDAIFSALGIESEDDLYKMVNFFLRFKAHHLSSAQ-VSISTHSN 571

  Fly   589 AE----------VFMKDQKPNRLQGA-AGGQPDEKEHRSTGDT-FLPKSEVAAKRCHNHYLVMEP 641
            ||          :.:..|...|...: :.|.|.|.|.:...|. .|...|:..:...:..:.:.|
  Rat   572 AERTSLVSALQHMSLMSQTDRRSSASKSDGDPTELEDQQGSDNGSLMGRELVEQEDLSSPMFIHP 636

  Fly   642 ALCLHAMNLFTSKMHKKMYEHEPGSILNAVNLIQITDAEIRNFWRQFSACFPASKCKLWKTLEHG 706
            ...|..::.|.:.: ||..:..|...|.......:.|.|   :|...:...|.||..||..|...
  Rat   637 NDVLKILDAFVTGL-KKPKDARPVQRLKKDTRNNLKDTE---YWESLAMVIPFSKQNLWDALFKA 697

  Fly   707 LNHYVEVLKMRVQYDAEVVFLRRQNEELRHLLQKF 741
            |..|..||..|.:...|...|.:||.|::.|||::
  Rat   698 LEKYYLVLTQRAKLLMENDSLEQQNAEMQSLLQQY 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10958	NP_572445.1	NYD-SP28	119..220	CDD:464307	29/100 (29%)
		SMC_prok_B	<123..>424	CDD:274008	87/304 (29%)
		NYD-SP28_assoc	684..741	CDD:464309	20/56 (36%)
Drc1	NP_001007010.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		9/32 (28%)
		Smc	<33..>277	CDD:440809	71/246 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	55..76		3/20 (15%)
		NYD-SP28	99..200	CDD:464307	29/100 (29%)
		Nup88	<187..387	CDD:462975	59/203 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..616		7/28 (25%)
		NYD-SP28_assoc	674..733	CDD:464309	21/61 (34%)