DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10958 and Drc1

DIOPT Version :9

Sequence 1:	NP_572445.1	Gene:	CG10958 / 31736	FlyBaseID:	FBgn0030004	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001007010.1	Gene:	Drc1 / 362712	RGDID:	1359318	Length:	754	Species:	Rattus norvegicus

Alignment Length:	750	Identity:	208/750 - (27%)
Similarity:	354/750 - (47%)	Gaps:	62/750 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EEEEVEPDLGPVDSWESFNDRIDGLIFNERCDKSVKKLDERRLAILNRVRQQFREA----PKGVA 82
            ||....|.|||     |.|.           |...:::..|||.|..|...:.|||    ..|..
  Rat    15 EEHLAAPILGP-----SVNS-----------DNPQERIQARRLRIAARQEARRREALGEYLDGKK 63

  Fly    83 ERCQAQKSPIDQRLELSSERLNELVRFGKELVTNVRVANERRELNRRLFEGAQKNQMHVKLQRES 147
            |..:.|.....|: |.|..:|.:|:..|.|||||::||.:.||::||:.|...|.|...||:.|.
  Rat    64 ESEEEQSKSYKQK-EESRLKLTKLLLCGTELVTNIQVAADIREIHRRVEEEETKRQRLEKLENEV 127

  Fly   148 VETMARFENIKARWTELEETNEPMLLWDQIEEQKKRIAEIMARKDEMISACQAEVDRMNAKYEFD 212
            ..:..:|:.|.::|.|..:...|..||:.:..|:...|.::..|:::||..|.|:...:.:|..|
  Rat   128 KTSQDKFDEITSKWEEGRQKRIPQELWEMLNNQQVHCAGLVEDKNKLISELQQELKIKDDQYVKD 192

  Fly   213 RERQAQDLCCLVERVDHQVETLKEAYKEHIQMLRQTIEEERQIFADNAVEKWRTFFDAMNANFDE 277
            .::|::|:..|:||::.||:::.:.:::.:..:.:..|.|||.......:||.....|.||.  |
  Rat   193 LKKQSEDITVLLERMEEQVKSVMKNFRQELNYIEKAFESERQELLTTNKKKWERALQAHNAK--E 255

  Fly   278 KANLVR--AREQFYARQ--TQQINESQEELTKSTRIRLEKECERLELELRRTRDNVLMNSEKLDY 338
            ...|:.  .|.:.|.:|  .|::.:.:|  ..|.:|:||::.:.||.:|::.:....:|.|||:|
  Rat   256 LEYLINRMKRVEDYEKQLNRQRVWDCEE--YNSIKIKLEQDVQILEQQLQQMKATYQLNQEKLEY 318

  Fly   339 NYQVLQKRNEENVIINNQQKRRVARLHEAIGRTRRGLKNLYNTGKRNIARLSSDIYKLHSNINDM 403
            |:|||:||:||:.:|.:||||::.|||:.:...|..........:.:...|:||..:|.:...|:
  Rat   319 NFQVLKKRDEESTVIKSQQKRKLNRLHDILNNLRTKYSKQIKQFQEDNQSLTSDYKRLVTQFKDL 383

  Fly   404 ESKAHQARLNNREKFDRIWEINYKELNLLVDRVYHIDRIIHEQQLAMPWSSP-------VPPIPN 461
            :.......:.:::||..||.:|..|...|..|.:.:|:|||.|.|.:||..|       |.|| :
  Rat   384 QKAIRHFIIIDQDKFREIWLMNEAEAKELAQRAFDVDKIIHSQHLGLPWKIPNFWFLNNVGPI-S 447

  Fly   462 INKAKKKRNNILEKFDMRIGRVPKNRVMPNSGVNCKPDIKELPPD-SLRLMRNLIRKLSDRGGFL 525
            :.:.:|....|||:..::.........|...     ....:||.. |.:..:.::..|.|..|||
  Rat   448 LQQQQKSVTQILEELLLQSEDEGTETAMSED-----ESYMDLPNQVSAKTTKKILVLLCDESGFL 507

  Fly   526 IEERLLKILEPYSEEEKCLVRIDNIFAALRIRHLRDVKELTKVFMPYT--YCPNCQPQGLSPRKC 588
            ||.:||.:|.|..:.|..|:|:|.||:||.|....|:.::...|:.:.  :..:.| ..:|....
  Rat   508 IESKLLSLLLPLEKSECYLLRLDAIFSALGIESEDDLYKMVNFFLRFKAHHLSSAQ-VSISTHSN 571

  Fly   589 AE----------VFMKDQKPNRLQGA-AGGQPDEKEHRSTGDT-FLPKSEVAAKRCHNHYLVMEP 641
            ||          :.:..|...|...: :.|.|.|.|.:...|. .|...|:..:...:..:.:.|
  Rat   572 AERTSLVSALQHMSLMSQTDRRSSASKSDGDPTELEDQQGSDNGSLMGRELVEQEDLSSPMFIHP 636

  Fly   642 ALCLHAMNLFTSKMHKKMYEHEPGSILNAVNLIQITDAEIRNFWRQFSACFPASKCKLWKTLEHG 706
            ...|..::.|.:.: ||..:..|...|.......:.|.|   :|...:...|.||..||..|...
  Rat   637 NDVLKILDAFVTGL-KKPKDARPVQRLKKDTRNNLKDTE---YWESLAMVIPFSKQNLWDALFKA 697

  Fly   707 LNHYVEVLKMRVQYDAEVVFLRRQNEELRHLLQKF 741
            |..|..||..|.:...|...|.:||.|::.|||::
  Rat   698 LEKYYLVLTQRAKLLMENDSLEQQNAEMQSLLQQY 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10958	NP_572445.1	NYD-SP28	120..220	CDD:291438	28/99 (28%)
CG10958	NP_572445.1	NYD-SP28_assoc	684..741	CDD:291441	20/56 (36%)
Drc1	NP_001007010.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		9/32 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..76		3/20 (15%)
		NYD-SP28	100..200	CDD:291438	28/99 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..616		7/28 (25%)
		NYD-SP28_assoc	674..732	CDD:291441	21/60 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341737
Domainoid	1	1.000	162	1.000	Domainoid score	I3905
eggNOG	1	0.900	-	-		E1_2CMDT
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H35977
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3026
OMA	1	1.010	-	-		QHG56349
OrthoDB	1	1.010	-	-		D246426at33208
OrthoFinder	1	1.000	-	-		FOG0008369
OrthoInspector	1	1.000	-	-		oto98730
orthoMCL	1	0.900	-	-		OOG6_104900
Panther	1	1.100	-	-	LDO	PTHR21625
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6353
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770