DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10958 and drc1

DIOPT Version :9

Sequence 1:	NP_572445.1	Gene:	CG10958 / 31736	FlyBaseID:	FBgn0030004	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001120940.1	Gene:	drc1 / 100034551	ZFINID:	ZDB-GENE-041001-218	Length:	670	Species:	Danio rerio

Alignment Length:	753	Identity:	210/753 - (27%)
Similarity:	349/753 - (46%)	Gaps:	110/753 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 HQ-ELVSDGSVEEEEEVEPDLGPVDSWESFNDRIDGLIFNERCDKSVKKLDERRLAILNRVRQQF 74
            || |..:.|  ||.||:.|      |.||              ||..:::..|||.:..|...|.
Zfish     2 HQTEAFAAG--EEAEELRP------SVES--------------DKKEERILARRLRLAARKEAQT 44

  Fly    75 RE-------APKGVAERCQAQKSPIDQRLELSSERLNELVRFGKELVTNVRVANERRELNRR--L 130
            |:       ..:.|.|..:..:..::.|    ..|:.:|...|.|||||::||.:.||.:||  |
Zfish    45 RQRLGEDDLGKEDVKEETRKSQKEVEHR----ERRMAKLKSDGLELVTNIQVAADARESDRRTEL 105

  Fly   131 FEGAQKNQMHVKLQRESVETMARFENIKARWTELEETNEPMLLWDQIEEQKKRIAEIMARKDEMI 195
            .||.:..:  .||:.|:..:..:||.|..:||:.:....|:.|.|.:..|::...:|:|.|:::|
Zfish   106 EEGHRLRR--EKLENEAKSSQEKFEEINRKWTDAKMKQTPLDLRDALSSQQQLCEQIIADKNKLI 168

  Fly   196 SACQAEVDRMNAKYEFDRERQAQDLCCLVERVDHQVETLKEAYKEHIQMLRQTIEEERQIFADNA 260
            |..|.|:...:.:|..|.:|||:|:..||||::.|:.|||::|:|.:..:..:::|||:......
Zfish   169 SELQQELKASDDRYVKDLKRQAKDIDLLVERMEEQISTLKKSYREDLHQIENSLDEERRTLLTKH 233

  Fly   261 VEKWRTFFDAMNANFDEKANLVRARE--QFYARQTQQINESQEELTKSTRIRLEKECERLELELR 323
            .:||.  .:..:.|..|..|::::..  :.||...|::.....|.....:||::.|.::|.::::
Zfish   234 KKKWE--HERKDRNEKELKNMMQSLSVMEEYADLLQKLRVQTAEEYNIDKIRMDTEVQKLRMKVQ 296

  Fly   324 RTRDNVLMNSEKLDYNYQVLQKRNEENVIINNQQKRRVARLHEAIGRTRRGLKNLYNTGKRNIAR 388
            :|:.|..||.|||||.|:||:|:.|||.||.:|.||::.|:.:.:...:..|.......|.....
Zfish   297 QTKFNCHMNEEKLDYKYEVLKKKEEENAIIKSQLKRKIIRMQDVLNNLKSKLTKQEKQSKAGNQS 361

  Fly   389 LSSDIYKLHSNINDMESKAHQARLNNREKFDRIWEINYKELNLLVDRVYHIDRIIHEQQLAMPWS 453
            ||:|..::.....|::.||......:.|:.:::|.:...|...|..|....||:||||||.:.|:
Zfish   362 LSNDYTRISQQYKDIQKKARHFAALDAERLEKLWLMCEDEAKALTHRALETDRVIHEQQLGLEWA 426

  Fly   454 SPVPPIPNINKAKKKRNNILEKFDMRIGRVPKNRVMPNSGVNCKPDIKELPPDSL-----RLMRN 513
            |  ||:|.:.::...:...............|..  |..|         |..|:.     |.:::
Zfish   427 S--PPLPFMERSGAVQQKTFRTATQAAADTLKGE--PGGG---------LDEDTAAGLNKRTVKS 478

  Fly   514 LIRKLSDRGGFLIEERLLKILEPYSEEEKCLVRIDNIFAALRIRHLRDVKELTKVFMPYTYCPNC 578
            ::..|.|..|||:|.:||.:|.|..:.|:.|:::|.||:|:.|...:||.::.:.||.|
Zfish   479 ILELLCDEMGFLVESKLLMLLSPLEKNEQSLIKLDAIFSAIGIESEKDVYKMAEFFMNY------ 537

  Fly   579 QPQGLSPRKCAEVFMKDQKPNRLQGAAGGQPDEKEHRS----TGDTFLPKSEVAAKRCHNHYLVM 639
                   |:....:.||:       .|.||.:..|..|    |.|......:..|:.|...
Zfish   538 -------RQHESKYTKDE-------TANGQGESAEELSNLIHTEDLLAALKDFTAQFCRQD---- 584

  Fly   640 EPALCLHAMNLFTSKMHKKMYEHEPGSILNAVNLIQITDAEIRNFWRQFSACFPASKCKLWKTLE 704
                        ....||       .|||   .|....|:|...:|...:...|.||.|||..|:
Zfish   585 ------------VQASHK-------SSIL---GLDMRDDSEDAVYWESIANVMPESKLKLWDALD 627

  Fly   705 HGLNHYVEVLKMRVQYDAEVVFLRRQNEELRHLLQKFT 742
            ..||.|..||..|.:...|...:::||.|||.||..:|
Zfish   628 TALNKYHAVLTERTELLMETQNIQQQNSELRQLLHLYT 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10958	NP_572445.1	NYD-SP28	120..220	CDD:291438	32/101 (32%)
CG10958	NP_572445.1	NYD-SP28_assoc	684..741	CDD:291441	22/56 (39%)
drc1	NP_001120940.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		14/45 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..72		5/32 (16%)
		NYD-SP28	93..193	CDD:291438	32/101 (32%)
		NYD-SP28_assoc	607..664	CDD:291441	22/56 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581758
Domainoid	1	1.000	180	1.000	Domainoid score	I3479
eggNOG	1	0.900	-	-		E1_2CMDT
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H35977
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2915
OMA	1	1.010	-	-		QHG56349
OrthoDB	1	1.010	-	-		D246426at33208
OrthoFinder	1	1.000	-	-		FOG0008369
OrthoInspector	1	1.000	-	-		oto40869
orthoMCL	1	0.900	-	-		OOG6_104900
Panther	1	1.100	-	-	LDO	PTHR21625
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4490
SonicParanoid	1	1.000	-	-		X6353
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800