DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2116 and ZBTB24

DIOPT Version :9

Sequence 1:NP_572444.2 Gene:CG2116 / 31735 FlyBaseID:FBgn0030003 Length:598 Species:Drosophila melanogaster
Sequence 2:NP_055612.2 Gene:ZBTB24 / 9841 HGNCID:21143 Length:697 Species:Homo sapiens


Alignment Length:639 Identity:141/639 - (22%)
Similarity:228/639 - (35%) Gaps:173/639 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 VLPANSDYSDEDNRGNVRVINTSDDATYVLLDNLGNEFEEDIIIVNENGVEKEMLMSKELRDFIV 79
            ::.|.:|:.:..:......:||: .|..|::.|..|:..:     .:.|..|::...:|.:..:.
Human   121 LVKAYTDFQNNHSSPKPTTLNTA-GAPVVVISNKKNDPPK-----RKRGRPKKVNTLQEEKSELA 179

  Fly    80 GS-----RVKDLTDDEQMPQFVVRELDMSEVGDLVEVEPEMEQEADYGDYGDYEHEPSYGHPRDN 139
            ..     ||.:...:.|  .|||:    .:.|.|.|.....|:|         |.||:....|:.
Human   180 AEEEIQLRVNNSVQNRQ--NFVVK----GDSGVLNEQIAAKEKE---------ESEPTCEPSREE 229

  Fly   140 ERVEEDLDMYPPSSPSLPPSPPRPPSPVVQPASKARNSARQIALRSFVSQKN-----NDDDDGSV 199
            |...|..:.|.|.:..             ..||::|.|.|:| .|| |..|:     :.:|.||.
Human   230 EMPVEKDENYDPKTED-------------GQASQSRYSKRRI-WRS-VKLKDYKLVGDQEDHGSA 279

  Fly   200 KEV-----KPSEKMLEEFKGPRRYMLFDDLIATIVDFDEDSTPLVEFSMISDIMDEKLPVECGIC 259
            |.:     :|.        ||.                                     ..|..|
Human   280 KRICGRRKRPG--------GPE-------------------------------------ARCKDC 299

  Fly   260 PDVM-HKSKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELCTLYFSTK 323
            ..|. :...|:.|.::|  .|...:.|..|.:.:.....|..|.|.|.|.|||.|.:|:...:||
Human   300 GKVFKYNHFLAIHQRSH--TGERPFKCNECGKGFAQKHSLQVHTRMHTGERPYTCTVCSKALTTK 362

  Fly   324 QDLRVHNQRRHLEKEHICEVCGKTFAQNTQLKRHREA---------------------------T 361
            ..|..|......:|...|:.|||.|:||.|||.|...                           |
Human   363 HSLLEHMSLHSGQKSFTCDQCGKYFSQNRQLKSHYRVHTGHSLPECKDCHRKFMDVSQLKKHLRT 427

  Fly   362 HEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGT 426
            |..::.|.||.|.|::....|||.||| :|.|: :...|..||....|:....|| ..:|..:..
Human   428 HTGEKPFTCEICGKSFTAKSSLQTHIR-IHRGE-KPYSCGICGKSFSDSSAKRRH-CILHTGKKP 489

  Fly   427 YVCHLCQEEFTDISYFDAHKRSIQCRSNTRRFVNADGNREGSDSESISGRNMNGQDDDYDGMGP- 490
            :.|..|..:|..:....||   ::..|.         .:..||:.||||.:...:..:...:.| 
Human   490 FSCPECNLQFARLDNLKAH---LKIHSK---------EKHASDASSISGSSNTEEVRNILQLQPY 542

  Fly   491 -LQEEYDEDDGLLVEDNQPEEQGSPSNRQYLDESEQQYVQLSDYDDQHLLVENAVDAEDGGEDLD 554
             |....:::..|||.|       |..|..::....|....::....|::..:.|.:.        
Human   543 QLSTSGEQEIQLLVTD-------SVHNINFMPGPSQGISIVTAESSQNMTADQAANL-------- 592

  Fly   555 ELLTE--DQYFNAVQQHHQQHQQHHGRGQDYN----------DELIYEITLKTE 596
            .|||:  :|..|.:....|:..:|.   |..|          .|.::.|||..|
Human   593 TLLTQQPEQLQNLILSAQQEQTEHI---QSLNMIESQMGPSQTEPVHVITLSKE 643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2116NP_572444.2 C2H2 Zn finger 256..275 CDD:275368 5/19 (26%)
C2H2 Zn finger 285..305 CDD:275368 5/19 (26%)
PHA00733 <308..357 CDD:177301 20/48 (42%)
C2H2 Zn finger 313..334 CDD:275368 6/20 (30%)
C2H2 Zn finger 341..362 CDD:275368 11/47 (23%)
C2H2 Zn finger 370..388 CDD:275368 8/17 (47%)
C2H2 Zn finger 400..418 CDD:275370 6/17 (35%)
C2H2 Zn finger 429..447 CDD:275368 5/17 (29%)
ZBTB24NP_055612.2 BTB 27..133 CDD:306997 2/11 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 131..176 9/50 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 209..254 14/66 (21%)
C2H2 Zn finger 296..316 CDD:275368 5/19 (26%)
COG5048 <321..480 CDD:227381 47/160 (29%)
C2H2 Zn finger 324..344 CDD:275368 5/19 (26%)
C2H2 Zn finger 352..372 CDD:275368 6/19 (32%)
C2H2 Zn finger 380..400 CDD:275368 11/19 (58%)
C2H2 Zn finger 408..428 CDD:275368 0/19 (0%)
C2H2 Zn finger 436..456 CDD:275368 10/20 (50%)
C2H2 Zn finger 464..480 CDD:275368 4/15 (27%)
C2H2 Zn finger 492..512 CDD:275368 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 652..697
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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