DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF382

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_116214.2	Gene:	ZNF382 / 84911	HGNCID:	17409	Length:	550	Species:	Homo sapiens

Alignment Length:	196	Identity:	67/196 - (34%)
Similarity:	94/196 - (47%)	Gaps:	10/196 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 VECGICPDVMHKSKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELCTL 318
            ::||  .....|:.|::|||||  .|...|.|..|...:|...||..|.|.|.|.:||.|..|..
Human   355 IDCG--KSFRQKATLTRHHKTH--TGEKAYECPQCGSAFRKKSYLIDHQRTHTGEKPYQCNECGK 415

  Fly   319 YFSTKQDLRVHNQRRHL-EKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKNFS 382
            .|..|..|.|| ||.|. ||.:||..|||:|.|.|.|..| :..|..::.:.|..|.|::.:...
Human   416 AFIQKTTLTVH-QRTHTGEKPYICNECGKSFCQKTTLTLH-QRIHTGEKPYICNECGKSFRQKAI 478

  Fly   383 LQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAHKR 447
            |..|.| :|.|::.. .||.||........:.||:| .|..:..|.|..|.:.|:..|....|::
Human   479 LTVHHR-IHTGEKSN-GCPQCGKAFSRKSNLIRHQK-THTGEKPYECKQCGKFFSCKSNLIVHQK 540

  Fly   448 S 448
            :
Human   541 T 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	7/18 (39%)
		C2H2 Zn finger	285..305	CDD:275368	7/19 (37%)
		PHA00733	<308..357	CDD:177301	23/49 (47%)
		C2H2 Zn finger	313..334	CDD:275368	9/20 (45%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		C2H2 Zn finger	370..388	CDD:275368	5/17 (29%)
		C2H2 Zn finger	400..418	CDD:275370	6/17 (35%)
		C2H2 Zn finger	429..447	CDD:275368	5/17 (29%)
ZNF382	NP_116214.2	Mediates interaction with TRIM28. /evidence=ECO:0000250	1..105
		Represses transcription. /evidence=ECO:0000250	5..46
		KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		Represses transcription. /evidence=ECO:0000250	70..211
		C2H2 Zn finger	214..234	CDD:275368
		Required for transcriptional repression activity, probably mediates sequence-specific DNA-binding. /evidence=ECO:0000250	296..550		67/196 (34%)
		C2H2 Zn finger	298..318	CDD:275368
		zf-H2C2_2	310..335	CDD:290200
		C2H2 Zn finger	326..346	CDD:275368
		COG5048	<354..533	CDD:227381	65/186 (35%)
		C2H2 Zn finger	354..374	CDD:275368	7/20 (35%)
		zf-H2C2_2	367..389	CDD:290200	10/23 (43%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	394..419	CDD:290200	11/24 (46%)
		C2H2 Zn finger	410..430	CDD:275368	9/20 (45%)
		zf-H2C2_2	423..445	CDD:290200	13/22 (59%)
		C2H2 Zn finger	438..458	CDD:275368	9/20 (45%)
		zf-H2C2_2	451..475	CDD:290200	6/24 (25%)
		C2H2 Zn finger	466..486	CDD:275368	6/20 (30%)
		C2H2 Zn finger	494..514	CDD:275368	7/20 (35%)
		zf-C2H2	494..514	CDD:278523	7/20 (35%)
		zf-H2C2_2	506..531	CDD:290200	8/25 (32%)
		C2H2 Zn finger	522..542	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910