DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF577

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001357376.1	Gene:	ZNF577 / 84765	HGNCID:	28673	Length:	485	Species:	Homo sapiens

Alignment Length:	234	Identity:	69/234 - (29%)
Similarity:	107/234 - (45%)	Gaps:	15/234 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 STPLVEFSMISDIMDEKLPVECGICPDVM-HKSKLSKHHKTHLVPGTNRYACIYCTETYRDCKYL 298
            |:|..:.:.:..|.....|.||.:|.... .|::|.:|.:|.  .|...:.|..|.:|:.....|
Human   139 SSPKSQLNDLQKICAGGKPHECSVCGRAFSRKAQLIQHQRTE--RGEKPHGCGECGKTFMRKIQL 201

  Fly   299 AGHARRHMGIRPYVCELCTLYFSTKQDLRVHNQRRHL-EKEHICEVCGKTFAQNTQLKRHREATH 362
            ..|.|.|.|.:|:.|..|...||.|..|.|| ||.|. ||.:.|..|||.|::..:|.|| :.:|
Human   202 TEHQRTHTGEKPHECSECGKAFSRKSQLMVH-QRTHTGEKPYRCSKCGKAFSRKCRLNRH-QRSH 264

  Fly   363 EKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGTY 427
            ..::.:.|..|.||:.:...|..|.| :|.|. :..||..||........:.||:: :|..:..|
Human   265 TGEKLYGCSVCGKAFSQKAYLTAHQR-LHTGD-KPYKCSDCGRTFYFKSDLTRHQR-IHTGEKPY 326

  Fly   428 VCHLCQEEFTDISYFDAHKRS------IQCRSNTRRFVN 460
            .|..|::.|...|....|:|:      ..||...:.|.:
Human   327 ECSECEKAFRSKSKLIQHQRTHTGERPYSCRECGKAFAH 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		PHA00733	<308..357	CDD:177301	20/49 (41%)
		C2H2 Zn finger	313..334	CDD:275368	10/20 (50%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		C2H2 Zn finger	370..388	CDD:275368	6/17 (35%)
		C2H2 Zn finger	400..418	CDD:275370	5/17 (29%)
		C2H2 Zn finger	429..447	CDD:275368	5/17 (29%)
ZNF577	NP_001357376.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		KRAB	25..83	CDD:214630
		COG5048	136..>217	CDD:227381	21/79 (27%)
		C2H2 Zn finger	160..180	CDD:275368	5/19 (26%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		COG5048	<194..399	CDD:227381	55/177 (31%)
		C2H2 Zn finger	216..236	CDD:275368	10/20 (50%)
		C2H2 Zn finger	244..264	CDD:275368	8/20 (40%)
		C2H2 Zn finger	272..292	CDD:275368	7/20 (35%)
		C2H2 Zn finger	300..320	CDD:275368	5/20 (25%)
		C2H2 Zn finger	328..348	CDD:275368	6/19 (32%)
		C2H2 Zn finger	356..376	CDD:275368	3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910