DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF397

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	XP_006722621.1	Gene:	ZNF397 / 84307	HGNCID:	18818	Length:	553	Species:	Homo sapiens

Alignment Length:	511	Identity:	110/511 - (21%)
Similarity:	191/511 - (37%)	Gaps:	124/511 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EEDIIIV------------NENGVEK--EMLMSKELRDFIVG---------SRVKDLTDDEQMPQ 94
            |:::|:|            .:||..:  :.|..::.|.|...         ||:::|.....||:
Human    18 EQELILVKVEDNFSWDEKFKQNGSTQSCQELFRQQFRKFCYQETPGPREALSRLQELCYQWLMPE 82

  Fly    95 FVVRE--LDMSEVGDLVEVEPE------MEQEADYGDYG-----DYEHE-PSYGHPRDNERVEED 145
            ...:|  |::..:...:.:.||      .:...:.|:..     |.|.| ...|.....|:.:..
Human    83 LHTKEQILELLVLEQFLSILPEELQIWVQQHNPESGEEAVTLLEDLEREFDDPGQQVGTEKSDVG 147

  Fly   146 LDMYPPSSPSLPPSPPRPP------------------------------SPVVQPASKARNSARQ 180
            ..:|......:|.||..|.                              .|.:.|.|...||  :
Human   148 KGIYSLEHVMVPASPQGPAVPWKDLTCLRASQESTDIHLQPLKTQLKSWKPCLSPKSDCENS--E 210

  Fly   181 IALRSFVSQKNND--DDDGSVKEVKPSEKML---------EEFKGPRRYMLFDDLIATIVD---- 230
            .|.:..:|::.:.  ..:.|.:.:...|..|         |:.:.|.:...|..:|.|...
Human   211 TATKEGISEEKSQGLPQEPSFRGISEHESNLVWKQGSATGEKLRSPSQGGSFSQVIFTNKSLGKR 275

  Fly   231 --FDEDSTPLV---EFSMISDIMDEKLPVECGIC-PDVMHKSKLSKHHKTHLVPGTNRYACIYCT 289
              :||....|:   :..|...:..|:.|..|.:| ......|.|::|.:.|  .|...|.|..|.
Human   276 DLYDEAERCLILTTDSIMCQKVPPEERPYRCDVCGHSFKQHSSLTQHQRIH--TGEKPYKCNQCG 338

  Fly   290 ETYRDCKYLAGHARRHMGIRPYVCELCTLYFSTKQDL----RVH--------------------- 329
            :.:....||..|.|.|.|.:.|.|..|...|:....|    ::|
Human   339 KAFSLRSYLIIHQRIHSGEKAYECSECGKAFNQSSALIRHRKIHTGEKACKCNECGKAFSQSSYL 403

  Fly   330 --NQRRHL-EKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKNFSLQEHIRNVH 391
              :||.|. ||.:.|..|||||:|:::|.|| :..|..:|.::|..|.||:.::..|..|.| :|
Human   404 IIHQRIHTGEKPYECNECGKTFSQSSKLIRH-QRIHTGERPYECNECGKAFRQSSELITHQR-IH 466

  Fly   392 MGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAHKR 447
            .|: :..:|..||.....:..:.||:: :|..:..|.|:.|.:.|...|....|:|
Human   467 SGE-KPYECSECGKAFSLSSNLIRHQR-IHSGEEPYQCNECGKTFKRSSALVQHQR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		PHA00733	<308..357	CDD:177301	19/76 (25%)
		C2H2 Zn finger	313..334	CDD:275368	7/47 (15%)
		C2H2 Zn finger	341..362	CDD:275368	10/20 (50%)
		C2H2 Zn finger	370..388	CDD:275368	6/17 (35%)
		C2H2 Zn finger	400..418	CDD:275370	5/17 (29%)
		C2H2 Zn finger	429..447	CDD:275368	5/17 (29%)
ZNF397	XP_006722621.1	SCAN	46..139	CDD:128708	17/92 (18%)
		SCAN	46..134	CDD:280241	16/87 (18%)
		COG5048	<297..546	CDD:227381	63/230 (27%)
		zf-C2H2	304..326	CDD:278523	5/21 (24%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		zf-H2C2_2	318..342	CDD:290200	7/25 (28%)
		C2H2 Zn finger	334..354	CDD:275368	6/19 (32%)
		zf-H2C2_2	346..371	CDD:290200	10/24 (42%)
		C2H2 Zn finger	362..382	CDD:275368	4/19 (21%)
		zf-H2C2_2	374..399	CDD:290200	2/24 (8%)
		C2H2 Zn finger	390..410	CDD:275368	2/19 (11%)
		zf-H2C2_2	402..427	CDD:290200	11/24 (46%)
		C2H2 Zn finger	418..438	CDD:275368	10/20 (50%)
		zf-H2C2_2	431..455	CDD:290200	9/24 (38%)
		C2H2 Zn finger	446..466	CDD:275368	7/20 (35%)
		zf-H2C2_2	458..482	CDD:290200	8/25 (32%)
		C2H2 Zn finger	474..494	CDD:275368	5/20 (25%)
		zf-H2C2_2	486..511	CDD:290200	7/25 (28%)
		C2H2 Zn finger	502..522	CDD:275368	6/19 (32%)
		zf-C2H2	528..550	CDD:278523
		C2H2 Zn finger	530..550	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910