DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZFP2

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_085116.2	Gene:	ZFP2 / 80108	HGNCID:	26138	Length:	461	Species:	Homo sapiens

Alignment Length:	237	Identity:	70/237 - (29%)
Similarity:	108/237 - (45%)	Gaps:	22/237 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 PVECGICPDVMHKS-KLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELC 316
            |.:|..|.....:| .|:.|.:||  .|...|.|..|.:.:....:|..|.|.|.|.:||.|..|
Human   213 PYKCNECGKAFTQSMNLTVHQRTH--TGEKPYECNECGKAFSQSMHLIVHQRSHTGEKPYECSQC 275

  Fly   317 TLYFSTKQDLRVHNQRRHL-EKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKN 380
            ...||....|.:| ||.|. ||.:.|..|||:|:|:|.|..| :..|...:.|:|..|.||:.||
Human   276 GKAFSKSSTLTLH-QRNHTGEKPYKCNKCGKSFSQSTYLIEH-QRLHSGVKPFECNECGKAFSKN 338

  Fly   381 FSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAH 445
            .||.:| |.:|.|: :..:|..||........:..| :.:|..:..|.|:.|.:.|:..:|...|
Human   339 SSLTQH-RRIHTGE-KPYECMVCGKHFTGRSSLTVH-QVIHTGEKPYECNECGKAFSQSAYLIEH 400

  Fly   446 KR------SIQCRSNTRRFVNADGNREGSDSESISGRNMNGQ 481
            :|      ..:|....:.|:.       :.|.::..|...|:
Human   401 QRIHTGEKPYECDQCGKAFIK-------NSSLTVHQRTHTGE 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		PHA00733	<308..357	CDD:177301	21/49 (43%)
		C2H2 Zn finger	313..334	CDD:275368	8/20 (40%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		C2H2 Zn finger	370..388	CDD:275368	9/17 (53%)
		C2H2 Zn finger	400..418	CDD:275370	4/17 (24%)
		C2H2 Zn finger	429..447	CDD:275368	5/17 (29%)
ZFP2	NP_085116.2	COG5048	99..451	CDD:227381	70/237 (30%)
		C2H2 Zn finger	104..124	CDD:275368
		C2H2 Zn finger	132..152	CDD:275368
		C2H2 Zn finger	160..180	CDD:275368
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	216..236	CDD:275368	5/19 (26%)
		C2H2 Zn finger	244..264	CDD:275368	5/19 (26%)
		C2H2 Zn finger	272..292	CDD:275368	8/20 (40%)
		C2H2 Zn finger	300..320	CDD:275368	9/20 (45%)
		C2H2 Zn finger	328..348	CDD:275368	10/20 (50%)
		C2H2 Zn finger	356..376	CDD:275368	4/20 (20%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		C2H2 Zn finger	412..432	CDD:275368	4/26 (15%)
		C2H2 Zn finger	440..460	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910