DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF552

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_079038.2	Gene:	ZNF552 / 79818	HGNCID:	26135	Length:	407	Species:	Homo sapiens

Alignment Length:	167	Identity:	55/167 - (32%)
Similarity:	82/167 - (49%)	Gaps:	7/167 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 EDSTPLVEFSMISDIMDEKLPVECGICPDVMH-KSKLSKHHKTHLVPGTNRYACIYCTETYRDCK 296
            :.|:....||....:...:.|..||||..:.: ||.|..|.:.|  .|...|.|..|.:.:|...
Human   247 KSSSKYDSFSNHQGVHTREKPYTCGICGKLFNSKSHLLVHQRIH--TGEKPYECEVCQKFFRHKY 309

  Fly   297 YLAGHARRHMGIRPYVCELCTLYFSTKQDLRVHNQRRHLEKEHICEVCGKTFAQNTQLKRHREAT 361
            :|..|.|.|.|.|||.|..|...|:.....|||.:....:|.:.|..|||:||:::.|.:||. .
Human   310 HLIAHQRVHTGERPYECSDCGKSFTHSSTFRVHKRVHTGQKPYECSECGKSFAESSSLTKHRR-V 373

  Fly   362 HEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKRRML 398
            |..::.:.|..|:|.:.:..||:.|.| ||  ||:.|
Human   374 HTGEKPYGCSECEKKFRQISSLRHHQR-VH--KRKGL 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	8/19 (42%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		PHA00733	<308..357	CDD:177301	17/48 (35%)
		C2H2 Zn finger	313..334	CDD:275368	6/20 (30%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		C2H2 Zn finger	370..388	CDD:275368	6/17 (35%)
		C2H2 Zn finger	400..418	CDD:275370
		C2H2 Zn finger	429..447	CDD:275368
ZNF552	NP_079038.2	KRAB	14..>55	CDD:214630
		KRAB	14..53	CDD:279668
		C2H2 Zn finger	93..113	CDD:275368
		C2H2 Zn finger	121..141	CDD:275368
		C2H2 Zn finger	214..234	CDD:275368
		COG5048	<243..407	CDD:227381	54/165 (33%)
		C2H2 Zn finger	244..262	CDD:275368	3/14 (21%)
		C2H2 Zn finger	270..290	CDD:275368	8/19 (42%)
		zf-H2C2_2	282..307	CDD:290200	7/26 (27%)
		C2H2 Zn finger	298..318	CDD:275368	6/19 (32%)
		zf-H2C2_2	310..335	CDD:290200	11/24 (46%)
		C2H2 Zn finger	326..346	CDD:275368	6/19 (32%)
		zf-H2C2_2	339..362	CDD:290200	8/22 (36%)
		C2H2 Zn finger	354..374	CDD:275368	9/20 (45%)
		C2H2 Zn finger	382..402	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4954
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050