DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2116 and ZNF215

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001341782.1	Gene:	ZNF215 / 7762	HGNCID:	13007	Length:	517	Species:	Homo sapiens

Alignment Length:	387	Identity:	82/387 - (21%)
Similarity:	142/387 - (36%)	Gaps:	79/387 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VLLDNLGNEFEEDIIIVNENGVEKEMLMSKELRDFIVGSRVKDLTDDEQMPQFVVRELDMSEVGD 107
            |:|:|..          |.|.:.|..|:||......:.|:.|....::::|:..:  .||..:..
Human   192 VMLENFR----------NLNSLRKAHLLSKPFESLKLESKKKRWIMEKEIPRKTI--FDMKSISG 244

  Fly   108 LVEVEPEMEQEADYGDYGDYEHEPSYGHPRDNE--------RVEEDLDMYPPSSPSLPPSPPRPP 164
                     :|:.:|.......|.  |||..:.        |.::..|:..|....:|.:.....
Human   245 ---------EESSHGVIMTRLTES--GHPSSDAWKGENWLYRNQKKWDINLPQEAFIPETIYTEE 298

  Fly   165 SPVVQPASKARNSARQIALRSFVSQKNNDDDDGSVKEVKPSEKMLEEFKGPRRYMLFDDLIATIV 229
            .......:|          :||        |..||..:...:..:...||..:.    |...|..
Human   299 EDFECSENK----------KSF--------DINSVSSICAIQVGIPSRKGSPKC----DKFKTYF 341

  Fly   230 DFDEDST--PLVEFSMISDIMDEKLPVECGICPDVMHKSKLSKHHKTHLVPGTNRYACIYCTETY 292
            .|:.||.  ...|:...:|:         .:..|:.|:    |.|.|     .|.|.|..|.:.:
Human   342 KFNLDSVGKQHSEYEYGNDL---------SLSTDIRHQ----KSHTT-----MNSYECYQCGKAF 388

  Fly   293 RDCKYLAGHARRHMGIRPYVCELCTLYFSTKQDLRVHNQRRHLE-KEHICEVCGKTFAQNTQLKR 356
            .....|..|...|.|.:||.|..|..:|:.:.:|..| |:.|.| |......|||.|:::..  .
Human   389 CRSSSLIRHQIIHTGEKPYKCSECGRFFNRRTNLTKH-QKLHAEAKACTSNKCGKAFSKSED--S 450

  Fly   357 HREATHEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRK 418
            :....|.....:||..|.|::.::.||..| :.:|.|: :..||..|......:..:.:|:|
Human   451 NNPTLHFGNNFYQCVNCGKSFNRSSSLIRH-QMIHTGE-KPFKCKECSKAFNRSSNLVKHQK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	4/18 (22%)
		C2H2 Zn finger	285..305	CDD:275368	4/19 (21%)
		PHA00733	<308..357	CDD:177301	15/49 (31%)
		C2H2 Zn finger	313..334	CDD:275368	6/20 (30%)
		C2H2 Zn finger	341..362	CDD:275368	4/20 (20%)
		C2H2 Zn finger	370..388	CDD:275368	6/17 (35%)
		C2H2 Zn finger	400..418	CDD:275370	3/17 (18%)
		C2H2 Zn finger	429..447	CDD:275368
ZNF215	NP_001341782.1	SCAN	44..132	CDD:307924
		KRAB	164..226	CDD:214630	11/43 (26%)
		zf-C2H2	379..401	CDD:306579	5/21 (24%)
		C2H2 Zn finger	381..401	CDD:275368	4/19 (21%)
		zf-H2C2_2	393..418	CDD:316026	9/24 (38%)
		C2H2 Zn finger	409..484	CDD:275368	21/78 (27%)
		C2H2 Zn finger	412..429	CDD:275368	5/17 (29%)
		COG5048	436..>517	CDD:227381	19/79 (24%)
		C2H2 Zn finger	492..512	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4954
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050