DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF184

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001305820.1	Gene:	ZNF184 / 7738	HGNCID:	12975	Length:	751	Species:	Homo sapiens

Alignment Length:	196	Identity:	62/196 - (31%)
Similarity:	96/196 - (48%)	Gaps:	7/196 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 PVECGICPDVMHK-SKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELC 316
            |.||..|.....: |.|::|.|||  .|...|.|..|.:::.....||.|.:.|.|.:||.|..|
Human   417 PYECNECGKAFSQHSNLTQHQKTH--TGEKPYDCAECGKSFSYWSSLAQHLKIHTGEKPYKCNEC 479

  Fly   317 TLYFSTKQDLRVHNQRRHLEKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKNF 381
            ...||....|..|.:....||...|..|||.|:..:.|.:|:: ||.:::.::|:.|.||:.::.
Human   480 GKAFSYCSSLTQHRRIHTREKPFECSECGKAFSYLSNLNQHQK-THTQEKAYECKECGKAFIRSS 543

  Fly   382 SLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAHK 446
            ||.:|.| :|.|: :..:|..||........:.:||| :|..:..|.|:.|...|....:...||
Human   544 SLAKHER-IHTGE-KPYQCHECGKTFSYGSSLIQHRK-IHTGERPYKCNECGRAFNQNIHLTQHK 605

  Fly   447 R 447
            |
Human   606 R 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	6/19 (32%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		PHA00733	<308..357	CDD:177301	16/48 (33%)
		C2H2 Zn finger	313..334	CDD:275368	6/20 (30%)
		C2H2 Zn finger	341..362	CDD:275368	7/20 (35%)
		C2H2 Zn finger	370..388	CDD:275368	7/17 (41%)
		C2H2 Zn finger	400..418	CDD:275370	4/17 (24%)
		C2H2 Zn finger	429..447	CDD:275368	4/17 (24%)
ZNF184	NP_001305820.1	KRAB	28..88	CDD:214630
		KRAB	28..67	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..212
		C2H2 Zn finger	224..244	CDD:275368
		zf-H2C2_2	236..261	CDD:290200
		COG5048	<248..409	CDD:227381
		C2H2 Zn finger	252..272	CDD:275368
		zf-H2C2_2	264..287	CDD:290200
		C2H2 Zn finger	280..300	CDD:275368
		zf-H2C2_2	292..317	CDD:290200
		C2H2 Zn finger	308..328	CDD:275368
		zf-H2C2_2	320..345	CDD:290200
		C2H2 Zn finger	336..356	CDD:275368
		zf-H2C2_2	348..373	CDD:290200
		COG5048	360..736	CDD:227381	62/196 (32%)
		C2H2 Zn finger	364..384	CDD:275368
		zf-H2C2_2	376..400	CDD:290200
		C2H2 Zn finger	392..412	CDD:275368
		zf-C2H2	418..440	CDD:278523	7/21 (33%)
		C2H2 Zn finger	420..440	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..457	CDD:290200	9/26 (35%)
		C2H2 Zn finger	448..468	CDD:275368	5/19 (26%)
		zf-H2C2_2	460..485	CDD:290200	10/24 (42%)
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
		zf-H2C2_2	488..513	CDD:290200	9/24 (38%)
		C2H2 Zn finger	504..524	CDD:275368	7/20 (35%)
		zf-H2C2_2	516..541	CDD:290200	8/25 (32%)
		C2H2 Zn finger	532..552	CDD:275368	8/20 (40%)
		zf-H2C2_2	544..569	CDD:290200	9/26 (35%)
		C2H2 Zn finger	560..580	CDD:275368	6/20 (30%)
		zf-H2C2_2	572..597	CDD:290200	8/25 (32%)
		C2H2 Zn finger	588..608	CDD:275368	6/19 (32%)
		zf-H2C2_2	600..625	CDD:290200	3/7 (43%)
		C2H2 Zn finger	616..636	CDD:275368
		zf-H2C2_2	628..653	CDD:290200
		C2H2 Zn finger	644..664	CDD:275368
		zf-H2C2_2	656..681	CDD:290200
		C2H2 Zn finger	672..692	CDD:275368
		zf-H2C2_2	684..709	CDD:290200
		C2H2 Zn finger	700..720	CDD:275368
		C2H2 Zn finger	728..748	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910