Protein Alignment CG2116 and ZNF180

DIOPT Version :9

• Sequence 1: NP_572444.2
• Gene: CG2116 / 31735
• FlyBaseID: FBgn0030003
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: NP_037388.3
• Gene: ZNF180 / 7733
• HGNCID: 12970
• Length: 692
• Species: Homo sapiens
• Alignment Length: 228
• Identity: 69/228 - (30%)
• Similarity: 109/228 - (47%)
• Gaps: 15/228 - (6%)

  Fly   229 VDFDEDSTPLVEFSMISDIM------DEKLPVECGIC-PDVMHKSKLSKHHKTHLVPGTNRYACI 286
            :.|:|......|.|..|.:.      .|:.|.||..| ......|.|..|.:||  .|...|.|.
Human   322 IPFEESQYKCSETSHSSSLTQNMRNNSEEKPFECNQCGKSFSWSSHLVAHQRTH--TGEKPYECS 384

  Fly   287 YCTETYRDCKYLAGHARRHMGIRPYVCELCTLYFSTKQDLRVHNQRRHL-EKEHICEVCGKTFAQ 350
            .|.:::....:|..|.|.|.|.:||.|..|...||....|.|| ||.|. ||.:.|..|||:|.|
Human   385 ECGKSFSRSSHLVSHQRTHTGEKPYRCNQCGKSFSQSYVLVVH-QRTHTGEKPYECNQCGKSFRQ 448

  Fly   351 NTQLKRHREATHEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMAR 415
            :.:|..| :.||..::.::|..|.|::.:::.|..|.| :|.|: :..:|..||.....::|:..
Human   449 SYKLIAH-QRTHTGEKPYECNQCGKSFIQSYKLIAHQR-IHTGE-KPYECNQCGKSFSQSYKLVA 510

  Fly   416 HRKEMHLSQGTYVCHLCQEEFTDISYFDAHKRS 448
            |:: .|..:..:.|:.|.:.|:..|...||:|:
Human   511 HQR-THTGEKPFECNQCGKSFSWSSQLVAHQRT 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		PHA00733	<308..357	CDD:177301	21/49 (43%)
		C2H2 Zn finger	313..334	CDD:275368	9/20 (45%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		C2H2 Zn finger	370..388	CDD:275368	5/17 (29%)
		C2H2 Zn finger	400..418	CDD:275370	5/17 (29%)
		C2H2 Zn finger	429..447	CDD:275368	6/17 (35%)
ZNF180	NP_037388.3	KRAB	72..133	CDD:214630
		KRAB	72..111	CDD:279668
		C2H2 Zn finger	249..267	CDD:275368
		C2H2 Zn finger	275..295	CDD:275368
		COG5048	332..692	CDD:227381	67/218 (31%)
		C2H2 Zn finger	355..375	CDD:275368	5/19 (26%)
		zf-H2C2_2	367..392	CDD:290200	8/26 (31%)
		C2H2 Zn finger	383..403	CDD:275368	5/19 (26%)
		zf-H2C2_2	395..420	CDD:290200	10/24 (42%)
		C2H2 Zn finger	411..431	CDD:275368	9/20 (45%)
		zf-H2C2_2	424..448	CDD:290200	13/24 (54%)
		C2H2 Zn finger	439..459	CDD:275368	8/20 (40%)
		zf-H2C2_2	455..476	CDD:290200	6/21 (29%)
		C2H2 Zn finger	467..487	CDD:275368	6/20 (30%)
		zf-H2C2_2	483..504	CDD:290200	7/22 (32%)
		C2H2 Zn finger	495..515	CDD:275368	5/20 (25%)
		zf-H2C2_2	508..531	CDD:290200	4/23 (17%)
		C2H2 Zn finger	523..543	CDD:275368	7/20 (35%)
		zf-H2C2_2	536..560	CDD:290200	3/7 (43%)
		C2H2 Zn finger	551..571	CDD:275368
		zf-H2C2_2	563..588	CDD:290200
		C2H2 Zn finger	579..599	CDD:275368
		zf-H2C2_2	592..616	CDD:290200
		C2H2 Zn finger	607..627	CDD:275368
		zf-H2C2_2	620..643	CDD:290200
		C2H2 Zn finger	635..655	CDD:275368
		zf-H2C2_2	648..670	CDD:290200
		C2H2 Zn finger	663..683	CDD:275368

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910