DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZBTB17

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001274532.1	Gene:	ZBTB17 / 7709	HGNCID:	12936	Length:	810	Species:	Homo sapiens

Alignment Length:	371	Identity:	88/371 - (23%)
Similarity:	134/371 - (36%)	Gaps:	78/371 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 SPSLPPSPPRPPSPV---------------------VQPASKARNSARQIALRSFVSQKNNDDDD 196
            :|..||.....|.|.                     |:||.|.....::        |:..:::.
Human   188 APREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKE--------QEEQEEEG 244

  Fly   197 GSVKEVKPSEKMLEEFKGPR--------------------------------RYMLFDDLIATIV 229
            ....|||.....||..:.|.                                ....:..:|....
Human   245 AGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKAYGSVIHKCE 309

  Fly   230 DFDEDSTPLVEFSMISDIMDEKLPVECGICPDVMHKSKLSK-HHKTH--LVPGTNRYACIYCTET 291
            |..::.|....|.....|...:.|..|..|..........| |.|||  |.|    |.|..|.::
Human   310 DCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLKP----YGCEECGKS 370

  Fly   292 YRDCKYLAGHARRHMGIRPYVCELCTLYFSTKQDLRVHNQRRHLEKEHICEVCGKTFAQNTQLKR 356
            ||....|..|.:||.|...|.||.|...|:|..:|:.|......||.:.|:.||::|:..|...|
Human   371 YRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMR 435

  Fly   357 HREATHEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMH 421
            |.| ||:..:..:|.:|.|.:.:..:|:.|:: :|:.. ..|||..||.|...:..:.||.: :|
Human   436 HLE-THDTDKEHKCPHCDKKFNQVGNLKAHLK-IHIAD-GPLKCRECGKQFTTSGNLKRHLR-IH 496

  Fly   422 LSQGTYVCHLCQEEFTDISYFDAH------KRSIQCRSNTRRFVNA 461
            ..:..|||..||.:|.|......|      ::..||....:.|..|
Human   497 SGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFTQA 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		PHA00733	<308..357	CDD:177301	15/48 (31%)
		C2H2 Zn finger	313..334	CDD:275368	7/20 (35%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		C2H2 Zn finger	370..388	CDD:275368	5/17 (29%)
		C2H2 Zn finger	400..418	CDD:275370	6/17 (35%)
		C2H2 Zn finger	429..447	CDD:275368	6/23 (26%)
ZBTB17	NP_001274532.1	BTB	14..109	CDD:279045
		BTB	25..109	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..295		16/114 (14%)
		Interaction with MYC	269..308		1/38 (3%)
		COG5048	306..637	CDD:227381	71/245 (29%)
		zf-C2H2	306..328	CDD:278523	3/21 (14%)
		C2H2 Zn finger	308..328	CDD:275368	3/19 (16%)
		zf-H2C2_2	320..344	CDD:290200	5/23 (22%)
		C2H2 Zn finger	336..356	CDD:275368	5/19 (26%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		zf-C2H2	390..412	CDD:278523	8/21 (38%)
		C2H2 Zn finger	392..412	CDD:275368	7/19 (37%)
		zf-H2C2_2	404..428	CDD:290200	7/23 (30%)
		C2H2 Zn finger	420..440	CDD:275368	8/20 (40%)
		zf-C2H2	446..468	CDD:278523	5/22 (23%)
		C2H2 Zn finger	448..468	CDD:275368	5/20 (25%)
		zf-C2H2	475..496	CDD:278523	7/21 (33%)
		C2H2 Zn finger	476..496	CDD:275368	6/20 (30%)
		zf-H2C2_2	488..512	CDD:290200	8/24 (33%)
		C2H2 Zn finger	504..524	CDD:275368	6/19 (32%)
		zf-H2C2_2	516..541	CDD:290200	4/24 (17%)
		C2H2 Zn finger	532..552	CDD:275368	3/11 (27%)
		zf-H2C2_2	544..569	CDD:290200
		C2H2 Zn finger	560..580	CDD:275368
		zf-H2C2_2	573..597	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	600..625	CDD:290200
		C2H2 Zn finger	616..635	CDD:275370
		C2H2 Zn finger	726..746	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910