DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2116 and ZNF649

DIOPT Version :9

Sequence 1:NP_572444.2 Gene:CG2116 / 31735 FlyBaseID:FBgn0030003 Length:598 Species:Drosophila melanogaster
Sequence 2:NP_075562.2 Gene:ZNF649 / 65251 HGNCID:25741 Length:505 Species:Homo sapiens


Alignment Length:517 Identity:114/517 - (22%)
Similarity:184/517 - (35%) Gaps:143/517 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 MSKELRDFIVGSRVKDLTDDEQMPQF-------VVRELDMSEVGDLVEV-----EPE----MEQE 118
            |:|......:.....|.|.:|.  ||       :.|::.:....:||.|     :|:    :||.
Human     1 MTKAQESLTLEDVAVDFTWEEW--QFLSPAQKDLYRDVMLENYSNLVSVGYQAGKPDALTKLEQG 63

  Fly   119 ADYGDYGDYEHEPSYGHPRDNERVEEDLDMYPPSSPSLPPSPPRPPSPVVQPASKARNSARQIAL 183
            .......|..|.|:  || :.|:.::.|..            |.....:::...:.....|  .|
Human    64 EPLWTLEDEIHSPA--HP-EIEKADDHLQQ------------PLQNQKILKRTGQRYEHGR--TL 111

  Fly   184 RSFVSQKNNDDDDGSVKEVKPSEKMLEEFKGPRRYMLFD--DLIATIVDFDEDSTPL-------- 238
            :|::...|        :..:.:.|...||.|...: |.|  :.:.|.::|.|...|:        
Human   112 KSYLGLTN--------QSRRYNRKEPAEFNGDGAF-LHDNHEQMPTEIEFPESRKPISTKSQFLK 167

  Fly   239 --------------------VEFSMISD---IMDEKLPVECGICPDVMHKS-------------- 266
                                ::.|.:::   |...|.|..|.:|....:|.              
Human   168 HQQTHNIEKAHECTDCGKAFLKKSQLTEHKRIHTGKKPHVCSLCGKAFYKKYRLTEHERAHRGEK 232

  Fly   267 ---------------KLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELC 316
                           :|::|.:.|  .|...|.|..|.:.:.....|..|.|.|.||:|:.|..|
Human   233 PHGCSLCGKAFYKRYRLTEHERAH--KGEKPYGCSECGKAFPRKSELTEHQRIHTGIKPHQCSEC 295

  Fly   317 TLYFSTKQDLRVHNQRRHL-EKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKN 380
            ...||.|..|.|| ||.|. ||.|.|..|||.|.|...|..| :.||..::.:.|..|.||:.:.
Human   296 GRAFSRKSLLVVH-QRTHTGEKPHTCSECGKGFIQKGNLNIH-QRTHTGEKPYGCIDCGKAFSQK 358

  Fly   381 FSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRK--------------------------- 418
            ..|..|.| .|.||...: ||.||..|.....:.||:|                           
Human   359 SCLVAHQR-YHTGKTPFV-CPECGQPCSQKSGLIRHQKIHSGEKPYKCSDCGKAFLTKTMLIVHH 421

  Fly   419 EMHLSQGTYVCHLCQEEFTDISYFDAHKR--SIQCRSNTRRFVN-ADGNREGSDSESISGRN 477
            ..|..:..|.|..|::.:..:|....|||  |.:.|.::.:..| :..:...|.||.:.|::
Human   422 RTHTGERPYGCDECEKAYFYMSCLVKHKRIHSREKRGDSVKVENPSTASHSLSPSEHVQGKS 483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2116NP_572444.2 C2H2 Zn finger 256..275 CDD:275368 5/47 (11%)
C2H2 Zn finger 285..305 CDD:275368 5/19 (26%)
PHA00733 <308..357 CDD:177301 23/49 (47%)
C2H2 Zn finger 313..334 CDD:275368 10/20 (50%)
C2H2 Zn finger 341..362 CDD:275368 8/20 (40%)
C2H2 Zn finger 370..388 CDD:275368 6/17 (35%)
C2H2 Zn finger 400..418 CDD:275370 7/17 (41%)
C2H2 Zn finger 429..447 CDD:275368 4/17 (24%)
ZNF649NP_075562.2 KRAB 8..68 CDD:214630 12/61 (20%)
KRAB 8..47 CDD:279668 8/40 (20%)
C2H2 Zn finger 180..200 CDD:275368 1/19 (5%)
zf-H2C2_2 193..215 CDD:290200 5/21 (24%)
C2H2 Zn finger 208..228 CDD:275368 3/19 (16%)
C2H2 Zn finger 236..256 CDD:275368 2/19 (11%)
COG5048 260..>321 CDD:227381 24/61 (39%)
C2H2 Zn finger 264..284 CDD:275368 5/19 (26%)
zf-H2C2_2 276..301 CDD:290200 10/24 (42%)
C2H2 Zn finger 292..312 CDD:275368 10/20 (50%)
zf-H2C2_2 305..329 CDD:290200 14/24 (58%)
C2H2 Zn finger 320..340 CDD:275368 8/20 (40%)
zf-H2C2_2 332..357 CDD:290200 8/25 (32%)
C2H2 Zn finger 348..368 CDD:275368 7/20 (35%)
C2H2 Zn finger 376..396 CDD:275368 8/19 (42%)
zf-H2C2_2 389..413 CDD:290200 3/23 (13%)
C2H2 Zn finger 404..424 CDD:275368 0/19 (0%)
C2H2 Zn finger 432..452 CDD:275368 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..481 5/25 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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