DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and znf574

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001004843.1	Gene:	znf574 / 448126	XenbaseID:	XB-GENE-1004140	Length:	857	Species:	Xenopus tropicalis

Alignment Length:	676	Identity:	134/676 - (19%)
Similarity:	212/676 - (31%)	Gaps:	229/676 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LDNLGNEF--EEDIIIVNE----------NGVEKEMLMSKELRDFIVGSRVKDLTDDEQMPQFVV 97
            |::.|..|  :|.|...|.          ||.|||.::::       |:...|.
Frog   222 LEHQGTHFSGQERISDTNSHLDQTPQLSLNGQEKEPIINQ-------GNTCTDY----------- 268

  Fly    98 RELDMSEVGDLVEVEPEMEQEADYGDYGDYEHEP--SYGHPRDNERVEEDLDMYPPSSPSLPPSP 160
                .:|..:|: |:||.||...  |....:.||  |.|...:..:..:||:.:..|..:.|.|.
Frog   269 ----QAENKELL-VQPEGEQAEQ--DSWTVDREPVFSCGDCSETFQTTKDLEEHQISHQNGPFSC 326

  Fly   161 PR-----PPSPVVQPASKA-RNSARQIAL---RSFVSQ--------------------------- 189
            |.     |..|.|....|: |:.:|.:.:   .:|||:
Frog   327 PLCSKVFPTYPEVGEHLKSHRSESRYLCVDCGLAFVSEAVLLNHRRSHLANPLFTCECGLTFLNM 391

  Fly   190 ----------KNNDDDDGSVKEVK------PSE-------------KMLEEFKGPRRYMLFDDLI 225
                      .:...|.|:|:|.|      ||.             .:|.:|...:|:      :
Frog   392 TRFLYHRRVHSSKQPDTGAVEEKKTVNSIAPSPAGNFHCDPCGKDFPLLSQFLRHQRF------V 450

  Fly   226 ATIVDFDEDSTPLVEFSMISDIMDEKL------PVECGICPDVMH-KSKLSKHHKTHLVPGTNRY 283
            ..:....:..|....|...|.:....|      |..|.:|....: ::.|.:|..||  .|...|
Frog   451 HALERRHKCPTCGKHFKKGSHLRTHMLTHTGERPYSCTVCSKSFNSQANLLRHRLTH--TGEKPY 513

  Fly   284 ACIYC------TETYRDCKYLAG----------------------HARRHMGIRPYVCELCTLYF 320
            .|..|      :.|.:..:|:.|                      |...|.|..||.|:.|.|.|
Frog   514 KCQLCGKAFSQSSTLQQHQYVHGQAYLYKCNECGINFHRPYRLLLHQYHHTGEYPYKCQDCGLSF 578

  Fly   321 STKQDLRVHNQRRHLEKEHICE-------------------------------VCGKTFAQNTQL 354
            ..|:.|.||......|:.|.|.                               :|||....:..|
Frog   579 LLKRLLEVHQLGHRGEEPHRCRECGTNFPSVQRLQDHRCSKAGDGGGEKLECPICGKKVTSDAHL 643

  Fly   355 KRHREATHEKKRR------------------------FQCEYCQKAYYKNFSLQEHIRNVHMGKR 395
            ..|..|.|...:|                        .:|..|.|.:....|||.| |.:|.|:
Frog   644 NTHVAAQHSGNKRSNVSSGKGTPVLPRNKLKGGGGKNLECSDCHKTFSTETSLQVH-RRIHTGE- 706

  Fly   396 RMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAHKR---------SIQC 451
            |...||.||...|.:..:..||: :|..:..:.|.:|.:.||.......|||         ...|
Frog   707 RPYPCPDCGKAFRQSTHLKDHRR-LHTGEKPFKCDVCGKAFTIAVRLSEHKRIHTGERPHSCPDC 770

  Fly   452 RSNTRRFVNADGNREGSDSESISGRNMNGQDDDYDGMGPLQEEYDEDDGLLVEDNQPEEQGSPSN 516
            ....|.|.|...:|:....:.:..:....|..|......:.|..:...  ::|..:...:||.
Frog   771 GRAYRSFSNLWKHRKLHREQQVQLQEPESQPADLSSTVAILETVETIP--IIETVEIFPEGST-- 831

  Fly   517 RQYLDESEQQYVQLSDYDDQHLLVEN 542
                       :.:.|...:.|.|||
Frog   832 -----------ISVQDIQFETLQVEN 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	285..305	CDD:275368	6/47 (13%)
		PHA00733	<308..357	CDD:177301	17/79 (22%)
		C2H2 Zn finger	313..334	CDD:275368	8/20 (40%)
		C2H2 Zn finger	341..362	CDD:275368	7/51 (14%)
		C2H2 Zn finger	370..388	CDD:275368	7/17 (41%)
		C2H2 Zn finger	400..418	CDD:275370	6/17 (35%)
		C2H2 Zn finger	429..447	CDD:275368	5/17 (29%)
znf574	NP_001004843.1	C2H2 Zn finger	17..37	CDD:275368
		C2H2 Zn finger	60..80	CDD:275368
		zf-C2H2_6	98..124	CDD:372808
		C2H2 Zn finger	101..121	CDD:275368
		C2H2 Zn finger	299..319	CDD:275368	3/19 (16%)
		C2H2 Zn finger	326..346	CDD:275368	5/19 (26%)
		C2H2 Zn finger	354..374	CDD:275368	3/19 (16%)
		C2H2 Zn finger	382..401	CDD:275368	0/18 (0%)
		C2H2 Zn finger	430..451	CDD:275368	3/26 (12%)
		COG5048	457..>768	CDD:227381	68/315 (22%)
		C2H2 Zn finger	459..479	CDD:275368	4/19 (21%)
		zf-H2C2_2	471..496	CDD:372612	4/24 (17%)
		C2H2 Zn finger	487..507	CDD:275368	4/19 (21%)
		C2H2 Zn finger	515..535	CDD:275368	4/19 (21%)
		C2H2 Zn finger	543..563	CDD:275368	1/19 (5%)
		C2H2 Zn finger	571..591	CDD:275368	8/19 (42%)
		C2H2 Zn finger	599..616	CDD:275368	1/16 (6%)
		C2H2 Zn finger	630..651	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	648..678		3/29 (10%)
		C2H2 Zn finger	683..703	CDD:275368	8/20 (40%)
		C2H2 Zn finger	711..731	CDD:275368	7/20 (35%)
		zf-H2C2_2	723..747	CDD:372612	5/24 (21%)
		C2H2 Zn finger	739..759	CDD:275368	7/19 (37%)
		C2H2 Zn finger	767..787	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910