DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF705A

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	XP_024304748.1	Gene:	ZNF705A / 440077	HGNCID:	32281	Length:	315	Species:	Homo sapiens

Alignment Length:	257	Identity:	68/257 - (26%)
Similarity:	114/257 - (44%)	Gaps:	35/257 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 RSFVSQKNNDDDDGSVKEVKPSEKMLEEFKGPRRYMLFDDLIATIVDFDEDSTPLVEFSMISDIM 248
            |.|: |..|.|.:.::|               :::|:   .:..|...|..::..:|.|:|.:.
Human    85 REFL-QDQNPDRESALK---------------KKHMI---SMHPITRKDASTSMTMENSLILED- 129

  Fly   249 DEKLPVECGIC-PDVMHKSKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYV 312
                |.||... .|..|.|.:::...||  .|...|....|.::.|:......|.:.|...:.|.
Human   130 ----PFECNDSGEDCTHSSTITQRLLTH--SGKKPYVSKQCGKSLRNLFSPKPHKQIHTKGKSYQ 188

  Fly   313 CELCTLYFSTKQDLRVHNQRRHLEKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAY 377
            |.||...::....||.|......|:.:.|.:|||.|.|.:.|:|| |.||..:|.::|..|.||:
Human   189 CNLCEKAYTNCFRLRRHKMTHTGERPYACHLCGKAFTQCSHLRRH-EKTHTGERPYKCHQCGKAF 252

  Fly   378 YKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMA--RHRKEMHLSQGTYVCHLCQEEFT 437
            .::|:|:.|.| .|:||    ||..|....:...:.:  |..|.:|..:..:.|.||.:.|:
Human   253 IQSFNLRRHER-THLGK----KCYECDKSGKAFSQSSGFRGNKIIHTGEKPHACLLCGKAFS 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	285..305	CDD:275368	3/19 (16%)
		PHA00733	<308..357	CDD:177301	15/48 (31%)
		C2H2 Zn finger	313..334	CDD:275368	6/20 (30%)
		C2H2 Zn finger	341..362	CDD:275368	10/20 (50%)
		C2H2 Zn finger	370..388	CDD:275368	7/17 (41%)
		C2H2 Zn finger	400..418	CDD:275370	3/19 (16%)
		C2H2 Zn finger	429..447	CDD:275368	4/9 (44%)
ZNF705A	XP_024304748.1	KRAB	22..81	CDD:214630
		C2H2 Zn finger	133..153	CDD:275368	4/19 (21%)
		COG5048	<136..315	CDD:227381	53/182 (29%)
		C2H2 Zn finger	162..181	CDD:275368	3/18 (17%)
		C2H2 Zn finger	189..209	CDD:275368	6/19 (32%)
		zf-H2C2_2	201..226	CDD:316026	9/24 (38%)
		C2H2 Zn finger	217..237	CDD:275368	10/20 (50%)
		zf-H2C2_2	229..254	CDD:316026	11/25 (44%)
		C2H2 Zn finger	245..265	CDD:275368	8/20 (40%)
		C2H2 Zn finger	273..293	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4954
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050