DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and su(Hw)

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster

Alignment Length:	698	Identity:	137/698 - (19%)
Similarity:	243/698 - (34%)	Gaps:	191/698 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NEVIEFVLPANSDYSD---EDNRGNVRVINTSDDATYVLLDNLGNEFEEDIIIVNENGVEK---E 67
            ::.|:|:|..:.:...   |:|.|. .::.|.||      ::||.:.:||    .|:...|   .
  Fly   157 DDTIDFILADDEEVVPGRIENNNGQ-EIVVTEDD------EDLGEDGDED----GEDSSGKGNSS 210

  Fly    68 MLMSKELRDFIVGS------RVKDLTDDEQMPQ----FVVRELDMSEVGDLVEVEPEMEQEAD-- 120
            ....||:.:.:.|.      ||:.|....:..:    :.:|:.||.:..:.:|.:..:.::.|
  Fly   211 QTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDIC 275

  Fly   121 -----------------------YGDYGDYEHEPSYGHP----------RDNERVEEDLDMYPPS 152
                                   :.....||......|.          ..|.|.|..|.::..
  Fly   276 FCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSEALLALHEE- 339

  Fly   153 SPSLPPSPPRPPSPVVQPASKARNSARQIALRSFV------------SQKNNDDDDGSVKEVKPS 205
                            |..|:.:..|.:|..:.|.            |..:|:.|..|.|.....
  Fly   340 ----------------QHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRV 388

  Fly   206 EKMLEEFKGPRRYMLFDDLIATIVDFDEDSTPLVEFSMISDIMDEKLPVECGICPDVMHK-SKLS 269
            ...|:..:...:..|...::                        :|....|..|.:..:. |.|:
  Fly   389 FYRLDNLRSHLKQHLGTQVV------------------------KKPEYMCHTCKNCFYSLSTLN 429

  Fly   270 KHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELCTLYFSTKQDLRVHNQRRH 334
            .|.:||  .|...:.|..|.:.:.....|..|.|.|.|.:||.|.:|...|:.|:.|..|.:|..
  Fly   430 IHIRTH--TGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHT 492

  Fly   335 LEKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKRRMLK 399
            .|:.|.|:.|||:|.|.|||:.|.: ||  .|.|.||.|.:.:.....|:.|::.....||.:..
  Fly   493 GERPHKCDECGKSFIQATQLRTHSK-TH--IRPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFS 554

  Fly   400 CPFCGMQCRDAHKMARHR-------KEMHLSQGTYV-------CHLCQEEFTDISYFDAHKRSI- 449
            |..|....|....:..|.       |:...|..:.|       |.:|.:.|........|.|::
  Fly   555 CAECKRNFRTPALLKEHMDEGKHSPKQQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIRTVH 619

  Fly   450 QCRSNTRRFVNADGNREGS---DSESI--------SGRNMNGQDDDYDGMGPLQEEY--DEDDG- 500
            :|..:....|....::...   :||.:        :|..::.|.   ||.|.:..|:  ||.||
  Fly   620 ECDPDDIFGVEPHPSKRAKKDIESEEVVPVALNTSAGSLISSQT---DGNGVVVREFLVDEGDGA 681

  Fly   501 --LLVEDNQPEE----QGSPSNRQYLDES---------EQQYVQLSDYDDQHLLVENAVDAEDGG 550
              .:..:|:...    .|:....|..||:         |.|...:...:.:..|..:...|.  .
  Fly   682 AQTITLENETYTILPLDGAIEGEQLTDEAGVKPEAKKEEAQVSPVVKKEQRKSLAASLAAAI--A 744

  Fly   551 EDLDELLTEDQYFNAVQQHHQQHQQHHGRGQDYNDELIYEITLKTEDN 598
            ::|:|..:||                     |::.|::.|..:|.::|
  Fly   745 DNLEESCSED---------------------DFSGEILTEEDIKLKEN 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		PHA00733	<308..357	CDD:177301	20/48 (42%)
		C2H2 Zn finger	313..334	CDD:275368	7/20 (35%)
		C2H2 Zn finger	341..362	CDD:275368	10/20 (50%)
		C2H2 Zn finger	370..388	CDD:275368	5/17 (29%)
		C2H2 Zn finger	400..418	CDD:275370	4/24 (17%)
		C2H2 Zn finger	429..447	CDD:275368	4/17 (24%)
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	2/20 (10%)
		COG5048	<312..517	CDD:227381	54/247 (22%)
		C2H2 Zn finger	321..341	CDD:275368	4/36 (11%)
		zf-C2H2	348..368	CDD:278523	3/19 (16%)
		C2H2 Zn finger	350..368	CDD:275368	2/17 (12%)
		C2H2 Zn finger	382..402	CDD:275368	2/19 (11%)
		C2H2 Zn finger	415..435	CDD:275368	5/19 (26%)
		zf-H2C2_2	428..451	CDD:290200	7/24 (29%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
		zf-H2C2_2	455..479	CDD:290200	9/23 (39%)
		COG5048	<467..620	CDD:227381	44/155 (28%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		zf-H2C2_2	484..508	CDD:290200	10/23 (43%)
		C2H2 Zn finger	499..519	CDD:275368	10/20 (50%)
		C2H2 Zn finger	525..545	CDD:275368	5/19 (26%)
		C2H2 Zn finger	555..572	CDD:275368	3/16 (19%)
		C2H2 Zn finger	598..615	CDD:275371	3/16 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446716
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840