DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2116 and topi

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	359	Identity:	90/359 - (25%)
Similarity:	141/359 - (39%)	Gaps:	94/359 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 EKLPVECGICPDV----------------MHKSKLSKHHKTHLVPGTNRYACIYCTETYRDCKYL 298
            :||.:.|..| ||                ::|.|..|..:........:|.|..|.::|....:|
  Fly   463 KKLLLPCDFC-DVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHL 526

  Fly   299 AGHARRHMGIRPYVC--ELCTLYFSTKQDLRVHNQRRHL-EKEHICEVCGKTFAQNTQLKRHREA 360
            ..|.|.|.|::|:||  |.|...|:.:.||..|.::.|. |:.::|.||||.|...:...:|| .
  Fly   527 WQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHR-L 590

  Fly   361 THEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKRRMLKCPFCGMQC-----RDAHKMARHRKEM 420
            .|..:||::||.|.|.:|:..:|:.|.| :|.|: :...|.||....     ||.|..|||
  Fly   591 IHRGERRYECEECGKRFYRADALKNHQR-IHTGE-KPYSCLFCTKTFRQRGDRDKHIRARH---- 649

  Fly   421 HLSQGTYVCHLCQEEFTDISYFDAHKRSIQCRSNTRRFVNADGNREGSDSESISGRNMNGQDDDY 485
                               |:.||:.|.:.   ..::|     ..|.:.::.....|...||:|.
  Fly   650 -------------------SHLDANSRLMM---QMQKF-----QLETAAAQKAQSHNPEQQDNDV 687

  Fly   486 DGMGPLQEEYDEDDGLLVEDNQPEEQGSPSNRQYLDESEQQ-------------------YVQL- 530
            .| |....:.....|.:  ..:|    |.:..||....|||                   |:|.
  Fly   688 AG-GASTSDVPSGSGFM--STEP----SVAEMQYSITPEQQEEMVCVPIDEVNNSFFMSHYMQAV 745

  Fly   531 ---SDYDDQHLLVENAVDAEDGGEDLDELLTEDQ 561
               .|...||::|     .|..|:::|.:...||
  Fly   746 PMEEDGSGQHIIV-----FEQPGQNMDMMSIYDQ 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	7/34 (21%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		PHA00733	<308..357	CDD:177301	17/51 (33%)
		C2H2 Zn finger	313..334	CDD:275368	7/22 (32%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		C2H2 Zn finger	370..388	CDD:275368	7/17 (41%)
		C2H2 Zn finger	400..418	CDD:275370	9/22 (41%)
		C2H2 Zn finger	429..447	CDD:275368	3/17 (18%)
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368
		COG5048	<450..647	CDD:227381	56/187 (30%)
		C2H2 Zn finger	469..490	CDD:275368	4/21 (19%)
		zf-C2H2	511..533	CDD:278523	7/21 (33%)
		C2H2 Zn finger	513..564	CDD:275368	17/50 (34%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..581	CDD:290200	11/25 (44%)
		C2H2 Zn finger	572..592	CDD:275368	8/20 (40%)
		zf-H2C2_2	585..609	CDD:290200	9/24 (38%)
		zf-C2H2	598..620	CDD:278523	8/22 (36%)
		C2H2 Zn finger	600..620	CDD:275368	8/20 (40%)
		zf-H2C2_2	612..637	CDD:290200	8/26 (31%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446677
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930