DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2116 and CG8319

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_649920.2	Gene:	CG8319 / 41165	FlyBaseID:	FBgn0037722	Length:	383	Species:	Drosophila melanogaster

Alignment Length:	407	Identity:	88/407 - (21%)
Similarity:	152/407 - (37%)	Gaps:	115/407 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 GVEKEML--MSKELRDFIVGSRVKD---------LTDDEQMPQ---------------------- 94
            |..:.||  ...::.:::.|:::.:         |..|:.|||
  Fly    10 GASENMLGIFDDQVEEYVDGAKLAEMVKTCADVQLDPDDAMPQKMCISCVHDARTAYGFKRRCEE 74

  Fly    95 ----FVVRELDMSEVGDLVEVEPEMEQEADYGDYGDYEHEPSYGHPRDNERVEEDLDMYPPSSPS 155
                |.:..|:    |.:::.||..|      |:...|: |..|:....:::.:::
  Fly    75 NYKKFYLAILN----GQVIKDEPNEE------DFLFIEN-PDKGNLEAKKKLNKEI--------- 119

  Fly   156 LPPSPPRPPSPVVQPASKARNSA-------RQIALRSFVSQKNNDDDDGSVKEVKPSEKMLEEFK 213
                     ....|.||:...|:       ||  |||..:|  ....:..:|:.|....:|:..|
  Fly   120 ---------KKTHQTASRTTKSSITTSRAGRQ--LRSIKNQ--TFKCELCIKQFKRQINLLDHMK 171

  Fly   214 ----------GPRRYMLFDDL--------IATIVDFDE-----DSTPLVEFSMISDIMDEKLPVE 255
                      ...|::...||        ..:.|:..|     .||..::.....| |.|:.|.:
  Fly   172 VHSNSHVCQNCEERFLFKADLDNHQCYRNSNSTVECPECLKVFSSTQSLDSHKCKD-MQERSPFQ 235

  Fly   256 CGICPDVMHKSKLSKHHKTHLV------PGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCE 314
            |..|.....:   .::.|.||:      .|...:.|.||...:.:...|..|...|||.||:.|.
  Fly   236 CPHCQQAFTR---EQNLKAHLLIHAESKQGNGPHKCSYCQTGFFNKSALKVHIHAHMGERPHACP 297

  Fly   315 LCTLYFSTKQDLRVHNQRRHLEKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYK 379
            .|...|.:||.|:||.:....||.:.|..|.|||:.|..|.:||. .|..:|.::|..|    .:
  Fly   298 FCVSNFRSKQALKVHIRIHTGEKPYQCPHCPKTFSDNNNLAKHRR-RHSDERPYKCSIC----LQ 357

  Fly   380 NFSLQEHIRNVHMGKRR 396
            :|..:.|::...:||.|
  Fly   358 DFREKHHLKRHFLGKHR 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	3/18 (17%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		PHA00733	<308..357	CDD:177301	19/48 (40%)
		C2H2 Zn finger	313..334	CDD:275368	8/20 (40%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		C2H2 Zn finger	370..388	CDD:275368	4/17 (24%)
		C2H2 Zn finger	400..418	CDD:275370
		C2H2 Zn finger	429..447	CDD:275368
CG8319	NP_649920.2	zf-AD	4..79	CDD:285071	9/68 (13%)
		COG5048	<153..368	CDD:227381	56/223 (25%)
		C2H2 Zn finger	153..173	CDD:275368	4/19 (21%)
		C2H2 Zn finger	179..196	CDD:275368	3/16 (19%)
		C2H2 Zn finger	207..227	CDD:275370	3/19 (16%)
		C2H2 Zn finger	236..256	CDD:275368	5/22 (23%)
		C2H2 Zn finger	268..288	CDD:275368	5/19 (26%)
		C2H2 Zn finger	296..316	CDD:275368	8/19 (42%)
		zf-H2C2_2	308..332	CDD:290200	9/23 (39%)
		zf-C2H2	322..344	CDD:278523	9/22 (41%)
		C2H2 Zn finger	324..344	CDD:275368	9/20 (45%)
		C2H2 Zn finger	352..368	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449795
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930