DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2116 and CG10274

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster

Alignment Length:	814	Identity:	142/814 - (17%)
Similarity:	241/814 - (29%)	Gaps:	348/814 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DEDNRGN--------VRVINTSDDATYVLLDNLGNEFEEDIIIVNENGVEKEMLMSKELRDFIVG 80
            ||::|.|        :.:|...:| .:.:|:::..|.|:         ||||:...
  Fly   124 DEEDRINFDPLLDHKMEMIENEED-VFKMLEHVDKEAEQ---------VEKEVKQD--------- 169

  Fly    81 SRVKDLTDDEQMPQFVVRELDMSEVGDLVEVEPEMEQEADYGDYGDYEHEPSYGHPRDNERVEED 145
                              |||.:::..:...|...|.|.|                     :::|
  Fly   170 ------------------ELDAADLMTIFAAESSEESEED---------------------IDQD 195

  Fly   146 LDMYPPSSPSLPPSPPRPPSPVVQPASKARNSARQIAL----------RSFVSQKNNDDDDGSV- 199
            :|..|.||..         ...|..|.:.|:::|.|..          :.|.:....:|:||..
  Fly   196 VDFEPNSSDG---------DDDVPLAQRLRDNSRMIPKAKAAVIKEEDQEFPTGSEEEDEDGEKS 251

  Fly   200 ----KEVKPSEKML----------EEFKGPRRY----------MLFDDLIATI-----------V 229
                |.:.|.|:.|          ::||...||          :.|...:.|.           :
  Fly   252 KSRRKRIPPGERHLHRIIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCKVETCRKGFTTAGGLRL 316

  Fly   230 DFDEDSTPLVEFSMISDIMDEKLPVECGI--CPDVMHKSKLSKHH--KTHLVPGTNR-------Y 283
            ..|...|.|.|..            .|.:  |.....:.:|...|  |.|   |..:       |
  Fly   317 HIDHAHTELSEVH------------SCNVDGCGKTFPRIRLLTFHMKKMH---GITKAAAPPRDY 366

  Fly   284 ACIYCTETYR-------------------DCKY----------LAGHARRHMGIRPYVCELCTLY 319
            .|..|.:.:|                   .|..          |..|..||.||:.|||..|.:.
  Fly   367 PCTECEKVFRCPMALKKHMYKHDGKELPFPCNICGKRFVINSALKDHLMRHAGIKNYVCPYCGVG 431

  Fly   320 FSTKQD----LRVHNQRR-------------------HLE------KEHICEVCGKTFAQNTQLK 355
            .:|:|:    :..|.|.:                   |::      |.:.|:.|||||.::...|
  Fly   432 KTTRQEWNTHILTHTQEKKFKCHICEHASHNKQSLANHIKIVHEKIKNYACQYCGKTFGKSHACK 496

  Fly   356 RHREATHEKKRRFQCEYCQKAYYKNFSLQEHI----------------RNVHMGK---------- 394
            .| |.||..::|.:|:.|.|.:....||.:|:                |.|.||:
  Fly   497 IH-EMTHTGEKRCECKVCGKKFLYPKSLTKHLKTHEKRVLRAIETYRQRQVEMGETPGEQFDNPP 560

  Fly   395 ------------------------------------RRMLK------------------------ 399
                                                ||:.:
  Fly   561 APPVEGISIEPIMSRNAADELLKVCAESVATIPKDPRRVQRVDLAQLAGTAVNPIPSVSVPSWSP 625

  Fly   400 ------------CPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAH------K 446
                        ||.||....:...|.||.|.:|.....:.|..|.:.|........|      :
  Fly   626 QVNFTKKEGKHICPGCGQGFNNIGNMKRHYKIIHEKVKDFACRFCPKRFAKAQTLRHHEWIHTGE 690

  Fly   447 RSIQCRSNTRRFVNADGNREGSDSESISGRNMNGQDDDYDGMGP----LQEEYDEDDGLLVEDNQ 507
            :..:|::....|          ..|:...|:....::....:.|    .:||.:|.:.   ...:
  Fly   691 KPFECKTCGTHF----------RQETALKRHQRTHENRPPVISPKFYAAREELEEQER---SKRE 742

  Fly   508 PEEQGSPSNRQYLDESEQQYVQL-----SD-----YDD-QHLLVENA-----VDAEDGGEDLDEL 556
            .:.|.....|:..:.:::|...|     ||     ||: |....|.|     :.|:...|:..:.
  Fly   743 AKRQADAKRREIAEAAKEQLSSLHKLESSDRSLHSYDEYQEAAAERAAASAELQAQQFEENEVKR 807

  Fly   557 LTEDQYFNAVQQHHQ-----QHQQHHGRGQDYND 585
            |.|::.....:..::     ||||...:.|...|
  Fly   808 LAEEERRKVQEAAYEQLQLLQHQQEVDKAQSSYD 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	5/22 (23%)
		C2H2 Zn finger	285..305	CDD:275368	6/48 (13%)
		PHA00733	<308..357	CDD:177301	18/77 (23%)
		C2H2 Zn finger	313..334	CDD:275368	6/43 (14%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		C2H2 Zn finger	370..388	CDD:275368	6/33 (18%)
		C2H2 Zn finger	400..418	CDD:275370	7/17 (41%)
		C2H2 Zn finger	429..447	CDD:275368	4/23 (17%)
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871
		C2H2 Zn finger	334..353	CDD:275368	3/18 (17%)
		C2H2 Zn finger	368..388	CDD:275368	3/19 (16%)
		COG5048	394..729	CDD:227381	59/345 (17%)
		C2H2 Zn finger	397..417	CDD:275368	3/19 (16%)
		C2H2 Zn finger	425..445	CDD:275368	4/19 (21%)
		C2H2 Zn finger	453..474	CDD:275368	1/20 (5%)
		C2H2 Zn finger	482..502	CDD:275368	9/20 (45%)
		C2H2 Zn finger	510..530	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368	8/20 (40%)
		C2H2 Zn finger	667..687	CDD:275368	4/19 (21%)
		zf-H2C2_2	680..704	CDD:290200	3/33 (9%)
		C2H2 Zn finger	695..715	CDD:275368	4/29 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449766
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930