DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2116 and pita

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_611806.3	Gene:	pita / 37730	FlyBaseID:	FBgn0034878	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	633	Identity:	145/633 - (22%)
Similarity:	250/633 - (39%)	Gaps:	137/633 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VLPANSDYSDEDNRGNVRVINTSDDATYVLLDNLGNEFEEDIIIVNENGVEKEMLMSKELRDFIV 79
            |:||.:....|..:   :::||...::            ..:||.:...:|..|:..:.    :.
  Fly   120 VVPAKTAEPSETPK---KLLNTMAKSS------------SQVIIEDVQVLESAMVTPRT----VA 165

  Fly    80 G-------SRVKDLTDDEQMPQFVVRELDMSEVGDLVE-VEPEMEQEADYGDYGDYEHEPSYGHP 136
            |       |...:|..|..      :||.|.:|..::| :..|:|:|     :.|...:.|...|
  Fly   166 GSSPVPRRSHAYELKVDNN------QELSMDDVQSMLEDMASELEKE-----FPDIPQKASPVKP 219

  Fly   137 RD-NERVEEDLDMYPPSSPSLPPSPPRPPSPVVQPASKARNSARQIALRSFV--SQKNNDDDDGS 198
            :. |:.....|:..|.:     |..||..:|.|:     |:.:..:|:.:.|  |....||.|..
  Fly   220 KVLNKSSIRILNKGPAA-----PVEPRLATPKVK-----RDDSGNVAIVTEVLDSDLPLDDQDDP 274

  Fly   199 VKEVK----------------PSEKMLEEFK-GPRRYMLFDDLIATIVDFDEDSTPLVEFSMISD 246
            .|..:                |.:::||..: ...|...|..|:.....|.:     .:.:..:.
  Fly   275 TKNAEKVATDVFPCPDCERSFPLQQLLEIHRLNHTRSRSFQCLLCEKSFFSK-----YDLAKHNF 334

  Fly   247 IMDEKLPVECGICPDVM-HKSKLSKHHKTHL-VPGTNRYACIYCTETYRDCKYLAGHARRHMGIR 309
            :...:.|.:|.||.... .|:.|.:|.:||. ||   ::.|:||.:.:...:.:..||.||...|
  Fly   335 VHTGERPFKCAICSKAFTRKALLHRHERTHTDVP---KFICVYCEKPFLSRQEMEKHAERHQKKR 396

  Fly   310 PYVCELCTLYFSTKQDLRVHNQRRHLEKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQ 374
            |:.|.:||..|:.||.|..|...........|:.|.::|:..::|.||..| |..||.:.|:||.
  Fly   397 PFQCGVCTKSFAFKQGLERHETVHSTNLPFPCQHCERSFSTASKLARHLVA-HAGKRAYPCKYCH 460

  Fly   375 KAYYKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDI 439
            |:|..:..|..|:|...........|..|.:...:.:.:..|.. :| :..:..|.:|:::..||
  Fly   461 KSYMLSHHLSRHLRTHTQTSDASFVCSECKVSYSNYNDLLDHAL-IH-ATASLKCPMCRKQIEDI 523

  Fly   440 ----SYFDAHKRSIQ--CRSNTRRFVNADGNREGSDSESISGRNMNGQDDDYDGMGPLQEEYDED 498
                |:.|.||:|.:  |......|:          ::....|::  :||....|.|.|.|: ||
  Fly   524 DSVESHMDQHKQSERHACEFCDHIFL----------TQKCLQRHI--EDDHVVEMEPYQNEF-ED 575

  Fly   499 DGLLVEDNQPEEQGSPSNRQYLDESEQQYVQLSDYDD------QHLLVENAVD---AEDGGEDLD 554
            ||        |.:|.      :||.|:   .|.|::|      :..:.|...|   .||..:|.|
  Fly   576 DG--------EGEGG------VDEKEE---HLDDFEDMDNVKQEEFVTEYLEDDALYEDHLDDSD 623

  Fly   555 ELLT----EDQYFNAVQQHHQQHQQHHGRGQDYNDELIYEITLKTEDN 598
            |..|    :.:..|..:...|..:|...|...       .||.||..|
  Fly   624 ESFTPPPPKQRKTNPPKDAQQSVRQTRSRDAQ-------RITQKTGKN 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	6/19 (32%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		PHA00733	<308..357	CDD:177301	14/48 (29%)
		C2H2 Zn finger	313..334	CDD:275368	8/20 (40%)
		C2H2 Zn finger	341..362	CDD:275368	7/20 (35%)
		C2H2 Zn finger	370..388	CDD:275368	7/17 (41%)
		C2H2 Zn finger	400..418	CDD:275370	3/17 (18%)
		C2H2 Zn finger	429..447	CDD:275368	7/21 (33%)
pita	NP_611806.3	zf-AD	17..92	CDD:214871
		COG5048	<281..506	CDD:227381	56/234 (24%)
		C2H2 Zn finger	288..308	CDD:275368	3/19 (16%)
		C2H2 Zn finger	316..336	CDD:275368	2/24 (8%)
		zf-H2C2_2	328..353	CDD:290200	4/24 (17%)
		C2H2 Zn finger	344..364	CDD:275368	6/19 (32%)
		C2H2 Zn finger	372..388	CDD:275370	3/15 (20%)
		C2H2 Zn finger	400..420	CDD:275368	8/19 (42%)
		C2H2 Zn finger	428..448	CDD:275368	7/20 (35%)
		C2H2 Zn finger	456..476	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..506	CDD:275368	3/20 (15%)
		HARE-HTH	<566..625	CDD:294801	22/76 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449768
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840