DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and Zfp287

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001100478.1	Gene:	Zfp287 / 303212	RGDID:	1308617	Length:	762	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	102/463 - (22%)
Similarity:	163/463 - (35%)	Gaps:	146/463 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 EQMPQFVVREL-----DMSEVGDLVEVEPEMEQEADYGDYGD-YEHEPSYGHPRDNERVEEDLDM 148
            |:.|.:..|::     |.|...:|.:.:|..|..:.|..|.| :|...:.....|.:...:.| :
  Rat   275 ERQPAYAFRKIHIDEDDFSLKSELSQEDPTEECLSKYDLYRDNFEKHTNLIIQFDTQSDSKTL-L 338

  Fly   149 YPPSSPS--------------LPPSPPRPPSPVVQPASKARNSARQIALRSFVSQKNNDDDDGSV 199
            |..|.|:              ||...|...:...:...|         ..|.::.:||...|.|.
  Rat   339 YNESKPTFTNVSSGGVVHGKILPGDKPYSCNVCGKKFRK---------YPSLLAHRNNHAKDKSY 394

  Fly   200 KEVKPSEKMLEEFK---------------------------GPRRYMLFDDLIATIVDFDEDSTP 237
            :    .|:..:|||                           ..|.::.....|.|
  Rat   395 E----CEECGKEFKHLSSLIAHQRMHTGEKPYECHQCGKAFSQRAHLTIHQRIHT---------- 445

  Fly   238 LVEFSMISDIMDEKLPVECGIC-PDVMHKSKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGH 301
                       .|| |.:|..| .|...::.|:.|.:||  .|...|.|:.|::|:.....|..|
  Rat   446 -----------GEK-PYKCNDCGKDFSQRAHLTIHQRTH--TGEKPYKCLECSKTFSHSSSLINH 496

  Fly   302 ARRHMGIRPYVCELCTLYFSTKQDLRVH---------------------------NQRRHL---- 335
            .|.|.|.:||:|..|...||....|..|                           :||.|.
  Rat   497 QRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRHQRIHSGEKC 561

  Fly   336 -------------------------EKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQK 375
                                     ||.:||.||||.|:|:..|.:|.. ||..::.::|..|.|
  Rat   562 YKCTECGKAFAHSSTLIQHQTTHTGEKSYICNVCGKAFSQSANLTQHHR-THTGEKPYKCSVCGK 625

  Fly   376 AYYKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDIS 440
            |:.::..|.:|.| :|.|: :..||..||...|....:.:|:: :|..:..|.||.|.:.|...|
  Rat   626 AFSQSVHLTQHQR-IHNGE-KPFKCNTCGKAYRQGANLTQHQR-VHTGEKPYKCHHCGKAFIYSS 687

  Fly   441 YFDAHKRS 448
            ..:.|:|:
  Rat   688 SLNQHRRT 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		PHA00733	<308..357	CDD:177301	22/104 (21%)
		C2H2 Zn finger	313..334	CDD:275368	8/47 (17%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		C2H2 Zn finger	370..388	CDD:275368	6/17 (35%)
		C2H2 Zn finger	400..418	CDD:275370	5/17 (29%)
		C2H2 Zn finger	429..447	CDD:275368	6/17 (35%)
Zfp287	NP_001100478.1	SCAN	46..133	CDD:280241
		KRAB	168..225	CDD:214630
		KRAB	168..207	CDD:279668
		C2H2 Zn finger	368..388	CDD:275368	3/28 (11%)
		zf-C2H2	394..416	CDD:278523	4/25 (16%)
		C2H2 Zn finger	396..416	CDD:275368	4/19 (21%)
		zf-H2C2_2	408..433	CDD:290200	0/24 (0%)
		COG5048	420..752	CDD:227381	72/304 (24%)
		C2H2 Zn finger	424..444	CDD:275368	1/19 (5%)
		zf-H2C2_2	436..461	CDD:290200	8/46 (17%)
		C2H2 Zn finger	452..472	CDD:275368	5/19 (26%)
		zf-H2C2_2	464..489	CDD:290200	9/26 (35%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		zf-H2C2_2	492..517	CDD:290200	10/24 (42%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		zf-H2C2_2	520..545	CDD:290200	2/24 (8%)
		C2H2 Zn finger	536..556	CDD:275368	2/19 (11%)
		zf-H2C2_2	548..573	CDD:290200	3/24 (13%)
		C2H2 Zn finger	564..584	CDD:275368	0/19 (0%)
		zf-C2H2	590..612	CDD:278523	10/22 (45%)
		C2H2 Zn finger	592..612	CDD:275368	9/20 (45%)
		zf-H2C2_2	604..629	CDD:290200	8/25 (32%)
		C2H2 Zn finger	620..640	CDD:275368	7/20 (35%)
		zf-H2C2_2	632..657	CDD:290200	9/26 (35%)
		C2H2 Zn finger	648..668	CDD:275368	5/20 (25%)
		zf-H2C2_2	660..685	CDD:290200	7/25 (28%)
		C2H2 Zn finger	676..696	CDD:275368	7/20 (35%)
		zf-H2C2_2	688..713	CDD:290200	2/8 (25%)
		C2H2 Zn finger	704..724	CDD:275368
		zf-H2C2_2	717..741	CDD:290200
		C2H2 Zn finger	732..752	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910