DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2116 and ZIK1

DIOPT Version :9

Sequence 1:NP_572444.2 Gene:CG2116 / 31735 FlyBaseID:FBgn0030003 Length:598 Species:Drosophila melanogaster
Sequence 2:NP_001010879.2 Gene:ZIK1 / 284307 HGNCID:33104 Length:487 Species:Homo sapiens


Alignment Length:220 Identity:68/220 - (30%)
Similarity:99/220 - (45%) Gaps:23/220 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   253 PVECGICPDVMHK-SKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELC 316
            |.||..|.....: |.|:.|.:.|  .|...|.|..|.:.:|....|..|.:.|.|.|||.|..|
Human   266 PWECNECGKFFSQTSHLNDHRRIH--TGERPYECSECGKLFRQNSSLVDHQKIHTGARPYECSQC 328

  Fly   317 TLYFSTKQDLRVHNQRRHL-EKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKN 380
            ...||.|..| |.:||.|. |:.:.|..||.:|:|:..|.:||. .|...:.::|..|.|::.:.
Human   329 GKSFSQKATL-VKHQRVHTGERPYKCGECGNSFSQSAILNQHRR-IHTGAKPYECGQCGKSFSQK 391

  Fly   381 FSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAH 445
            .:|.:|.| ||.|: |..||..||.....:..:.:||: :|.....|.|..|.:.|:..|....|
Human   392 ATLIKHQR-VHTGE-RPYKCGDCGKSFSQSSILIQHRR-IHTGARPYECGQCGKSFSQKSGLIQH 453

  Fly   446 ------KRSIQCRSNTRRFVNADGN 464
                  :|..:|        |..||
Human   454 QVVHTGERPYEC--------NKCGN 470

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2116NP_572444.2 C2H2 Zn finger 256..275 CDD:275368 5/19 (26%)
C2H2 Zn finger 285..305 CDD:275368 5/19 (26%)
PHA00733 <308..357 CDD:177301 20/49 (41%)
C2H2 Zn finger 313..334 CDD:275368 9/20 (45%)
C2H2 Zn finger 341..362 CDD:275368 8/20 (40%)
C2H2 Zn finger 370..388 CDD:275368 5/17 (29%)
C2H2 Zn finger 400..418 CDD:275370 4/17 (24%)
C2H2 Zn finger 429..447 CDD:275368 5/23 (22%)
ZIK1NP_001010879.2 KRAB 27..>68 CDD:214630
KRAB 27..66 CDD:279668
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 71..94
C2H2 Zn finger 215..233 CDD:275368
C2H2 Zn finger 241..261 CDD:275368
zf-H2C2_2 253..278 CDD:290200 4/11 (36%)
COG5048 <269..449 CDD:227381 59/186 (32%)
C2H2 Zn finger 269..289 CDD:275368 5/19 (26%)
zf-H2C2_2 281..306 CDD:290200 7/26 (27%)
C2H2 Zn finger 297..317 CDD:275368 5/19 (26%)
zf-H2C2_2 309..334 CDD:290200 10/24 (42%)
C2H2 Zn finger 325..345 CDD:275368 9/20 (45%)
zf-H2C2_2 338..362 CDD:290200 10/24 (42%)
C2H2 Zn finger 353..373 CDD:275368 8/20 (40%)
zf-H2C2_2 366..390 CDD:290200 7/24 (29%)
C2H2 Zn finger 381..401 CDD:275368 6/20 (30%)
zf-H2C2_2 394..418 CDD:290200 11/25 (44%)
C2H2 Zn finger 409..429 CDD:275368 5/20 (25%)
zf-H2C2_2 422..446 CDD:290200 7/24 (29%)
C2H2 Zn finger 437..457 CDD:275368 5/19 (26%)
C2H2 Zn finger 465..485 CDD:275368 4/14 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 104 1.000 Inparanoid score I4954
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.960

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