DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF777

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	XP_005250037.1	Gene:	ZNF777 / 27153	HGNCID:	22213	Length:	875	Species:	Homo sapiens

Alignment Length:	437	Identity:	104/437 - (23%)
Similarity:	163/437 - (37%)	Gaps:	105/437 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ENGVEKEMLMSKELRDFIVGSRVKDLTDDEQMPQFVVRELDMSEVGDLVEVEPEMEQEADYGDYG 125
            ||.:|:....|.|.               .::.|.:|::.:.:| |.:::.|.:.|:|.:..:..
Human   463 ENTLEESTEGSSEF---------------SELKQMLVQQRNCTE-GIVIKTEEQDEEEEEEEEDE 511

  Fly   126 DYEHEPSYGHPRDNERVEEDLDMYP---PSSPSLPPSPPRPPSPVVQPASKARNSARQIALRSFV 187
            ..:|..|.|  :.:.|.|..:...|   ..||....||  ||..:..||
Human   512 LPQHLQSLG--QLSGRYEASMYQTPLPGEMSPEGEESP--PPLQLGNPA---------------- 556

  Fly   188 SQKNNDDDDGSVKEVKPS---EKMLEEFKGP-------RRYMLFDDLIATIVDFDEDSTPLVEFS 242
                       ||.:.||   |:.|.|.:|.       ||    .:...|.::..:.....:...
Human   557 -----------VKRLAPSVHGERHLSENRGASSQQQRNRR----GERPFTCMECGKSFRLKINLI 606

  Fly   243 MISDIMDEKLPVECGICP-DVMHKSKLSKHHKTHLV----------------------------- 277
            :......::.|.||..|. ...||.:|:.|.:.|.|
Human   607 IHQRNHIKEGPYECAECEISFRHKQQLTLHQRIHRVRGGCVSPERGPTFNPKHALKPRPKSPSSG 671

  Fly   278 ---PGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELCTLYFSTKQDLRVHNQRRHLEKEH 339
               .|...|.|..|..::.....|..|...|.|.|||.|..|...|.....|.:| ||.|..|..
Human   672 SGGGGPKPYKCPECDSSFSHKSSLTKHQITHTGERPYTCPECKKSFRLHISLVIH-QRVHAGKHE 735

  Fly   340 ---ICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKRRMLKCP 401
               ||.:|||:|::.:.|.|| :.||..:|.|:|..|:|::.:...|..|.| || .:.|...||
Human   736 VSFICSLCGKSFSRPSHLLRH-QRTHTGERPFKCPECEKSFSEKSKLTNHCR-VH-SRERPHACP 797

  Fly   402 FCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAHKRS 448
            .||......|.:..||: :|..:..|.|..|.:.||...:...|:|:
Human   798 ECGKSFIRKHHLLEHRR-IHTGERPYHCAECGKRFTQKHHLLEHQRA 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	6/19 (32%)
		C2H2 Zn finger	285..305	CDD:275368	4/19 (21%)
		PHA00733	<308..357	CDD:177301	19/51 (37%)
		C2H2 Zn finger	313..334	CDD:275368	7/20 (35%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		C2H2 Zn finger	370..388	CDD:275368	5/17 (29%)
		C2H2 Zn finger	400..418	CDD:275370	6/17 (35%)
		C2H2 Zn finger	429..447	CDD:275368	5/17 (29%)
ZNF777	XP_005250037.1	KRAB	329..387	CDD:214630
		KRAB_A-box	329..368	CDD:143639
		zf-C2H2	590..612	CDD:278523	1/21 (5%)
		C2H2 Zn finger	592..612	CDD:275368	0/19 (0%)
		zf-H2C2_2	604..629	CDD:290200	4/24 (17%)
		C2H2 Zn finger	620..640	CDD:275368	6/19 (32%)
		CpXC	681..>730	CDD:291051	16/49 (33%)
		C2H2 Zn finger	682..702	CDD:275368	4/19 (21%)
		COG5048	<684..870	CDD:227381	54/165 (33%)
		zf-H2C2_2	694..717	CDD:290200	9/22 (41%)
		C2H2 Zn finger	713..730	CDD:275370	6/17 (35%)
		zf-C2H2	738..760	CDD:278523	9/22 (41%)
		C2H2 Zn finger	740..760	CDD:275368	8/20 (40%)
		zf-H2C2_2	752..776	CDD:290200	10/24 (42%)
		C2H2 Zn finger	768..788	CDD:275368	6/20 (30%)
		zf-H2C2_2	781..805	CDD:290200	10/25 (40%)
		C2H2 Zn finger	796..816	CDD:275368	7/20 (35%)
		zf-H2C2_2	808..833	CDD:290200	7/25 (28%)
		C2H2 Zn finger	824..844	CDD:275368	6/20 (30%)
		zf-H2C2_2	836..861	CDD:290200	2/8 (25%)
		C2H2 Zn finger	852..872	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4954
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960