DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF658

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001304845.1	Gene:	ZNF658 / 26149	HGNCID:	25226	Length:	1059	Species:	Homo sapiens

Alignment Length:	215	Identity:	68/215 - (31%)
Similarity:	101/215 - (46%)	Gaps:	15/215 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 PVECGICPDVM-HKSKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELC 316
            |.||..|.... |.|.|..||:.|  .|...|.|..|..::.....|..|.|.|.|.:||.|..|
Human   601 PYECSDCEKTFAHNSALRAHHRIH--TGEKPYECNECGRSFAHISVLKAHQRIHTGEKPYECNEC 663

  Fly   317 TLYFSTKQDLRVHNQRRHL-EKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKN 380
            ...|:....||.| ||.|. .|.:.|..|.||||.|:.||.| :..|..::.::|..|:|.:..|
Human   664 GRSFTYNSALRAH-QRIHTGRKPYECSDCEKTFAHNSALKIH-QRIHTGEKPYECNECEKTFAHN 726

  Fly   381 FSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAH 445
            .:|:.| :|:|.|: ::.:|..||.......:::.||: :|..:..|.|..|.:.|:..||...|
Human   727 SALRAH-QNIHTGE-KLYECSECGKTFFQKTRLSTHRR-IHTGEKPYECSKCGKTFSQKSYLSGH 788

  Fly   446 KR------SIQCRSNTRRFV 459
            :|      ..:|....:.||
Human   789 ERIHTGEKPYECNVCGKTFV 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	7/19 (37%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		PHA00733	<308..357	CDD:177301	21/49 (43%)
		C2H2 Zn finger	313..334	CDD:275368	8/20 (40%)
		C2H2 Zn finger	341..362	CDD:275368	10/20 (50%)
		C2H2 Zn finger	370..388	CDD:275368	6/17 (35%)
		C2H2 Zn finger	400..418	CDD:275370	4/17 (24%)
		C2H2 Zn finger	429..447	CDD:275368	6/17 (35%)
ZNF658	NP_001304845.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	279..296	CDD:275368
		C2H2 Zn finger	299..319	CDD:275368
		C2H2 Zn finger	328..347	CDD:275368
		C2H2 Zn finger	355..375	CDD:275368
		COG5048	371..789	CDD:227381	63/194 (32%)
		C2H2 Zn finger	389..406	CDD:275368
		C2H2 Zn finger	414..434	CDD:275368
		C2H2 Zn finger	442..462	CDD:275368
		C2H2 Zn finger	520..540	CDD:275368
		zf-H2C2_2	532..557	CDD:290200
		C2H2 Zn finger	548..568	CDD:275368
		zf-H2C2_2	560..585	CDD:290200
		C2H2 Zn finger	576..596	CDD:275368
		zf-H2C2_2	588..613	CDD:290200	4/11 (36%)
		C2H2 Zn finger	604..624	CDD:275368	7/19 (37%)
		zf-H2C2_2	616..641	CDD:290200	8/26 (31%)
		COG5048	628..1044	CDD:227381	57/186 (31%)
		C2H2 Zn finger	632..652	CDD:275368	5/19 (26%)
		zf-H2C2_2	645..669	CDD:290200	10/23 (43%)
		C2H2 Zn finger	660..680	CDD:275368	8/20 (40%)
		zf-H2C2_2	672..697	CDD:290200	12/25 (48%)
		C2H2 Zn finger	688..708	CDD:275368	10/20 (50%)
		zf-H2C2_2	700..725	CDD:290200	7/25 (28%)
		C2H2 Zn finger	716..736	CDD:275368	7/20 (35%)
		C2H2 Zn finger	744..764	CDD:275368	5/20 (25%)
		zf-H2C2_2	757..781	CDD:290200	7/24 (29%)
		C2H2 Zn finger	772..792	CDD:275368	7/19 (37%)
		zf-H2C2_2	784..809	CDD:290200	6/25 (24%)
		C2H2 Zn finger	800..820	CDD:275368	3/9 (33%)
		zf-H2C2_2	812..837	CDD:290200
		C2H2 Zn finger	828..848	CDD:275368
		zf-H2C2_2	844..864	CDD:290200
		C2H2 Zn finger	856..876	CDD:275368
		zf-H2C2_2	868..892	CDD:290200
		C2H2 Zn finger	884..903	CDD:275368
		C2H2 Zn finger	912..932	CDD:275368
		C2H2 Zn finger	940..960	CDD:275368
		zf-H2C2_2	953..977	CDD:290200
		C2H2 Zn finger	968..988	CDD:275368
		zf-H2C2_2	980..1005	CDD:290200
		C2H2 Zn finger	996..1016	CDD:275368
		zf-H2C2_2	1009..1033	CDD:290200
		C2H2 Zn finger	1024..1045	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910