DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF620

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	XP_016861553.1	Gene:	ZNF620 / 253639	HGNCID:	28742	Length:	467	Species:	Homo sapiens

Alignment Length:	398	Identity:	94/398 - (23%)
Similarity:	146/398 - (36%)	Gaps:	90/398 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LGNEFEEDIIIVNENGVEKEML-----MSKELRDF--IVGSRVKDLTDDEQMPQFVVRELDMSEV 105
            :|.|....|...:|...|||.|     :|||...|  :||.          :|..|.:.||.
Human   123 MGREALRGICPGDEARTEKEGLTPKDHVSKETESFRLMVGG----------LPGNVSQHLDF--- 174

  Fly   106 GDLVEVEPE-------MEQEADYGDYGDYEHEPSYGHPRDNERVEEDLDMYPPSSPSLPPSPPRP 163
            |..:| :|:       ..:...:.|.....|| :| ..::.|:.|: |......|..|..:...|
Human   175 GSSLE-QPQGHWIIKTKSKRRHFTDTSARHHE-AY-EVKNGEKFEK-LGKNISVSTQLTTNQTNP 235

  Fly   164 PSPV-----------VQPASKARNSARQIALRSFVSQKNNDDDDGSVKEVKPSEKMLEEFKGPRR 217
            ...:           :|.|...|:.......:||                        |.|...:
Human   236 SGQISYECGQCGRYFIQMADFHRHEKCHTGEKSF------------------------ECKECGK 276

  Fly   218 YMLFDDLIATIVDFDEDSTPLVEFSMISDIMDEKLPVECGIC-PDVMHKSKLSKHHKTHLVPGTN 281
            |..::.|             |:...:|.   ..|.|.:|..| ..:...:.|.:|.:.|  .|..
Human   277 YFRYNSL-------------LIRHQIIH---TGKKPFKCKECGKGLSSDTALIQHQRIH--TGEK 323

  Fly   282 RYACIYCTETYRDCKYLAGHARRHMGIRPYVCELCTLYFSTKQDLRVHNQRRHL-EKEHICEVCG 345
            .|.|..|.:.:........|.|.|.|.:.|.|..|...||......|| ||.|. ||.:.|:.||
Human   324 PYECKECGKAFSSSSVFLQHQRFHTGEKLYECNECWKTFSCSSSFTVH-QRMHTGEKPYECKECG 387

  Fly   346 KTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDA 410
            |..:.||.|.:| :..|..::.|:|:.|.||:.:..:|.:|.| ||.|: :..:|..||......
Human   388 KRLSSNTALTQH-QRIHTGEKPFECKECGKAFNQKITLIQHQR-VHTGE-KPYECKVCGKTFSWC 449

  Fly   411 HKMARHRK 418
            .:...|:|
Human   450 GRFILHQK 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	285..305	CDD:275368	4/19 (21%)
		PHA00733	<308..357	CDD:177301	19/49 (39%)
		C2H2 Zn finger	313..334	CDD:275368	8/20 (40%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		C2H2 Zn finger	370..388	CDD:275368	6/17 (35%)
		C2H2 Zn finger	400..418	CDD:275370	4/17 (24%)
		C2H2 Zn finger	429..447	CDD:275368
ZNF620	XP_016861553.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910