DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and Zfp768

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_666314.1	Gene:	Zfp768 / 233890	MGIID:	2384582	Length:	568	Species:	Mus musculus

Alignment Length:	534	Identity:	126/534 - (23%)
Similarity:	179/534 - (33%)	Gaps:	156/534 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LLDNLGNEFEEDIIIVNENG--VEKEMLMSKELRDFIVGSRVKDLTDDEQMPQFVVRELDMSEVG 106
            |.|..||..|      ||.|  .::|.....|:.:...|...:....:.|.|:|..:
Mouse    28 LKDPAGNTSE------NEEGEISQREGNGDYEVEEIPFGLEPQSPEFEPQSPEFESQ-------- 78

  Fly   107 DLVEVEPEMEQEA---DYGDYGDYEHEPSYGHPRDNE------RVEEDLDMYPPSSPSLPPSPP- 161
                 .|..|.|:   :....|.....|.:. ||..|      ..|.....|.|.||...|..|
Mouse    79 -----SPRFEPESPGFESRSPGFVPPSPEFA-PRSPESDPQSPEFESQSPKYEPRSPGCHPRSPG 137

  Fly   162 -RPPSPVVQPASKARNSARQIALRSFVSQ-------------KNNDD------------------ 194
             .|.||..:|.|....|...    .|.||             :|:.|
Mouse   138 CEPGSPRYEPKSPGYGSKSP----EFESQSPGYESQSPGYEPQNSGDGVQNSEFKTHSPEFETQS 198

  Fly   195 ---DDGSVKEVKPSEK----------MLEEF-KGPRRYMLFDDLIATIVDFDEDSTPLV---EFS 242
               .:|:...:.|.||          .|:.| :|     ..:.....:..||..|..|:   :|.
Mouse   199 SKFQEGAEMPLSPEEKNPLSISLGVHPLDSFTQG-----FGEQPTGALPPFDMPSGALLAAPQFE 258

  Fly   243 MISDIMD-------------------EKLPVECGICPDVMHK-SKLSKHHKTHLVPGTNRYACIY 287
            |:.:.::                   ...|..||||.....: |.|.:|.:.|  .|...|.|..
Mouse   259 MLQNPLNLTGTLRGPGRRGGRARGGQGPRPNICGICGKSFGRGSTLIQHQRIH--TGEKPYKCEV 321

  Fly   288 CTETYRDCKYLAGHARRHMGIRPYVCELCTLYFSTKQDLRVHNQRRHLEKEHICEVCGKTFAQNT 352
            |::.:.....|..|.|.|.|.|||.|..|...|:....|..|.:....:|.:.|..|||.|..::
Mouse   322 CSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSS 386

  Fly   353 QLKRHREATHEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKR---------------------- 395
            .|.|| :.||..:|.:.|..|.|.|.:|.||:.|.| ||.|:|
Mouse   387 YLLRH-QRTHSHERPYSCPECGKCYSQNSSLRSHQR-VHTGQRPFSCGICGKSFSQRSALIPHAR 449

  Fly   396 -----RMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAHKRSIQ----- 450
                 :..|||.||.:...:..:|.|.: .||...||.|..|.:.|...|....|:||..
Mouse   450 SHAREKPFKCPECGKRFGQSSVLAIHAR-THLPGRTYSCPDCGKTFNRSSTLIQHQRSHTGERPY 513

  Fly   451 ---------CRSNT 455
                     |||:|
Mouse   514 RCAVCGKGFCRSST 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	7/19 (37%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		PHA00733	<308..357	CDD:177301	15/48 (31%)
		C2H2 Zn finger	313..334	CDD:275368	5/20 (25%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		C2H2 Zn finger	370..388	CDD:275368	8/17 (47%)
		C2H2 Zn finger	400..418	CDD:275370	6/17 (35%)
		C2H2 Zn finger	429..447	CDD:275368	5/17 (29%)
Zfp768	NP_666314.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..223		44/218 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..247		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..287		0/22 (0%)
		C2H2 Zn finger	291..311	CDD:275368	7/19 (37%)
		zf-H2C2_2	304..328	CDD:290200	7/25 (28%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		COG5048	<327..532	CDD:227381	60/204 (29%)
		zf-H2C2_2	331..355	CDD:290200	10/23 (43%)
		C2H2 Zn finger	347..367	CDD:275368	5/19 (26%)
		zf-H2C2_2	359..382	CDD:290200	7/22 (32%)
		zf-C2H2	373..395	CDD:278523	8/22 (36%)
		C2H2 Zn finger	375..395	CDD:275368	8/20 (40%)
		zf-C2H2	401..423	CDD:278523	9/22 (41%)
		C2H2 Zn finger	403..423	CDD:275368	9/20 (45%)
		zf-H2C2_2	415..440	CDD:290200	8/25 (32%)
		C2H2 Zn finger	431..451	CDD:275368	0/19 (0%)
		zf-H2C2_2	447..466	CDD:290200	5/18 (28%)
		C2H2 Zn finger	459..479	CDD:275368	6/20 (30%)
		zf-C2H2	485..507	CDD:278523	7/21 (33%)
		C2H2 Zn finger	487..507	CDD:275368	6/19 (32%)
		zf-H2C2_2	500..522	CDD:290200	3/21 (14%)
		C2H2 Zn finger	515..535	CDD:275368	4/13 (31%)
		zf-H2C2_2	528..552	CDD:290200	126/534 (24%)
		zf-C2H2	541..563	CDD:278523
		C2H2 Zn finger	543..563	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910