DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF629

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001073886.1	Gene:	ZNF629 / 23361	HGNCID:	29008	Length:	869	Species:	Homo sapiens

Alignment Length:	434	Identity:	104/434 - (23%)
Similarity:	169/434 - (38%)	Gaps:	103/434 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 DLTDDEQMPQFVVRELDMSEVGDLVEVEPEMEQEADYGDYGDYEHEPSYGHPRDNERVEEDLDMY 149
            ||...||.|....|..:    .:..|..|..|...:....||....|   ..:|:..:..:....
Human    11 DLQGPEQSPNDAHRGAE----SENEEESPRQESSGEEIIMGDPAQSP---ESKDSTEMSLERSSQ 68

  Fly   150 PPSSPSLPPSP-----------P-RPPSPVVQPA----SKARNSARQI-ALRSFVSQKNNDDDDG 197
            .||.|..||:|           | .||:|.|.|.    :||..::.|. ||.::.|......::.
Human    69 DPSVPQNPPTPLGHSNPLDHQIPLDPPAPEVVPTPSDWTKACEASWQWGALTTWNSPPVVPANEP 133

  Fly   198 SVKEV---KP--SEKMLEEFKGPRRYMLFDDLIATIVDFDEDSTPLVEFSMISDIMDEKLPVECG 257
            |::|:   :|  :||                                             |..|.
Human   134 SLRELVQGRPAGAEK---------------------------------------------PYICN 153

  Fly   258 ICPDVMHK-SKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELCTLYFS 321
            .|.....: |||.:|.:.|  .|.....|..|.:::....:|..|.|.|.|.:||.|..|...||
Human   154 ECGKSFSQWSKLLRHQRIH--TGERPNTCSECGKSFTQSSHLVQHQRTHTGEKPYKCPDCGKCFS 216

  Fly   322 TKQDLRVHNQRRHL-EKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKNFSLQE 385
            ...:| |.:||.|. ||.:.|..|.|.|.|:|.|.:| :.:|..::.::|..|::|:|::..|.:
Human   217 WSSNL-VQHQRTHTGEKPYKCTECEKAFTQSTNLIKH-QRSHTGEKPYKCGECRRAFYRSSDLIQ 279

  Fly   386 HIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAHKRS-- 448
            | :..|.|: :..|||.||.:....|.:.:|:| :|..:..|.|..|.:.|...|....|:|:
Human   280 H-QATHTGE-KPYKCPECGKRFGQNHNLLKHQK-IHAGEKPYRCTECGKSFIQSSELTQHQRTHT 341

  Fly   449 -------IQCRSNTRRFVNADGNREGSDSESISGRNMNGQDDDY 485
                   ::|           |...|..|..|..:..:.::|.:
Human   342 GEKPYECLEC-----------GKSFGHSSTLIKHQRTHLREDPF 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	6/19 (32%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		PHA00733	<308..357	CDD:177301	20/49 (41%)
		C2H2 Zn finger	313..334	CDD:275368	8/20 (40%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		C2H2 Zn finger	370..388	CDD:275368	6/17 (35%)
		C2H2 Zn finger	400..418	CDD:275370	6/17 (35%)
		C2H2 Zn finger	429..447	CDD:275368	5/17 (29%)
ZNF629	NP_001073886.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105		25/100 (25%)
		COG5048	146..521	CDD:227381	70/292 (24%)
		zf-C2H2	150..172	CDD:278523	6/21 (29%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-C2H2	179..200	CDD:278523	5/20 (25%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		zf-H2C2_2	192..216	CDD:290200	9/23 (39%)
		C2H2 Zn finger	208..228	CDD:275368	8/20 (40%)
		zf-H2C2_2	220..245	CDD:290200	11/25 (44%)
		C2H2 Zn finger	236..256	CDD:275368	8/20 (40%)
		zf-H2C2_2	248..273	CDD:290200	6/25 (24%)
		C2H2 Zn finger	264..284	CDD:275368	6/20 (30%)
		zf-H2C2_2	276..299	CDD:290200	9/24 (38%)
		C2H2 Zn finger	292..312	CDD:275368	7/20 (35%)
		zf-H2C2_2	304..329	CDD:290200	7/25 (28%)
		C2H2 Zn finger	320..340	CDD:275368	6/19 (32%)
		zf-H2C2_2	332..355	CDD:290200	4/33 (12%)
		C2H2 Zn finger	348..368	CDD:275368	5/30 (17%)
		zf-H2C2_2	361..384	CDD:290200	2/14 (14%)
		C2H2 Zn finger	376..396	CDD:275368
		zf-H2C2_2	389..412	CDD:290200
		zf-C2H2	402..424	CDD:278523
		C2H2 Zn finger	404..424	CDD:275368
		zf-H2C2_2	416..439	CDD:290200
		C2H2 Zn finger	432..452	CDD:275368
		zf-H2C2_2	445..469	CDD:290200
		C2H2 Zn finger	460..480	CDD:275368
		zf-H2C2_2	472..497	CDD:290200
		C2H2 Zn finger	488..508	CDD:275368
		C2H2 Zn finger	516..536	CDD:275368
		C2H2 Zn finger	571..591	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..651
		C2H2 Zn finger	664..684	CDD:275368
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	770..790	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	787..837
		C2H2 Zn finger	844..864	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910