DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF582

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001307300.2	Gene:	ZNF582 / 147948	HGNCID:	26421	Length:	517	Species:	Homo sapiens

Alignment Length:	320	Identity:	77/320 - (24%)
Similarity:	142/320 - (44%)	Gaps:	34/320 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 DIMDEKLPVECGICPDVMHK-SKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIR 309
            :|...|.|.||..|....:. |...:|.:.|  .|...|.|..|.:.:.....|..|.|.|.|.:
Human   219 NIHSGKKPYECKECGKAFNSGSNFIQHQRVH--TGEKPYECKDCEKAFSRSSQLIEHQRTHTGEK 281

  Fly   310 PYVCELCTLYFSTKQDLRVHNQRRHLEKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQ 374
            ||.|:.|...|:....|:||.:....||.:.|:.|||||:..:||.:| :..|..::.::|:.|.
Human   282 PYQCKECGKAFNRISHLKVHYRIHTGEKPYACKECGKTFSHRSQLIQH-QTVHTGRKLYECKECG 345

  Fly   375 KAYYKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDI 439
            ||:.:..:|..|.| :|.|: :..:|..||...|.:.::.:|:: :|..:..|.|.:|...|..:
Human   346 KAFNQGSTLIRHQR-IHTGE-KPYECKVCGKAFRVSSQLKQHQR-IHTGEKPYQCKVCGRAFKRV 407

  Fly   440 SYFDAH------KRSIQCRSNTRRFVNADGNREGSDSESISGRNMNGQDDDYDGMGPLQEEYDED 498
            |:...|      ::..:|:...:.|.:.        |:.|..:.::.:...|        ||.|.
Human   408 SHLTVHYRIHTGEKPYECKECGKAFSHC--------SQLIHHQVIHTEKKPY--------EYKEC 456

  Fly   499 DGLLVEDNQPEEQGSPSNRQ-YLDESEQQYVQLSDYD----DQHLLVENAVDAEDGGEDL 553
            :..|..|:...:.....||: :::....:...:|.|.    .:.:|..|.::..:|...|
Human   457 EKTLSHDSTTVQPQRMHNRETHVNIINVEKPSISSYPLLIIREFMLASNHMNGSNGESPL 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		PHA00733	<308..357	CDD:177301	18/48 (38%)
		C2H2 Zn finger	313..334	CDD:275368	6/20 (30%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		C2H2 Zn finger	370..388	CDD:275368	6/17 (35%)
		C2H2 Zn finger	400..418	CDD:275370	5/17 (29%)
		C2H2 Zn finger	429..447	CDD:275368	5/23 (22%)
ZNF582	NP_001307300.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910