DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and AgaP_AGAP003111

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	XP_312793.5	Gene:	AgaP_AGAP003111 / 1273780	VectorBaseID:	AGAP003111	Length:	910	Species:	Anopheles gambiae

Alignment Length:	290	Identity:	76/290 - (26%)
Similarity:	123/290 - (42%)	Gaps:	49/290 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 EFSMISDIMD----------EKLPVECGICPDVMH-KSKLSKHHKTHLVPGTNRYACIYCTETYR 293
            ||:.|.::.:          .|...:|..|....: .|.|:.|.:||  .|...:.|..|..::.
Mosquito   264 EFTRIDNLREHLRSHMGQGARKRDYQCPYCAKSFYGSSLLNIHIRTH--TGEKPFPCDLCPMSFP 326

  Fly   294 DCKYLAGHARRHMGIRPYVCELCTLYFSTKQDLRVHNQRRHLEKEHICEVCGKTFAQNTQLKRHR 358
            ....|..|.|:|.|.|||.|:.|:..|:.::.|..|.:....||.|.|:.|||.|.|.|||:.|
Mosquito   327 STGALRKHRRKHTGERPYRCDECSATFAARETLNRHRKTHTGEKPHECDQCGKRFIQATQLRAH- 390

  Fly   359 EATHEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGK--RRMLKCPFCGMQCRDAHKMARHRKEMH 421
            ..||..:..|||..|..::.:...|.:||:..|.|:  ....:||...::..|   :|||.. :|
Mosquito   391 ALTHSGENAFQCSECDASFNRKARLNDHIKFTHRGEHPHECDQCPKTFLRKED---LARHLL-IH 451

  Fly   422 LSQGTYVCHLCQEEFTDISYFDAHKRS------IQCRSNTRRFVNADGNREGSDSESISGRNMNG 480
            .....:.|.:|.:.||.......|:|:      :||:..:..|          ..|....|:|..
Mosquito   452 SESKPFECLVCNKFFTTKHAIQLHQRTHDEDNPVQCKVCSGTF----------KREDCLLRHMRS 506

  Fly   481 QDDDYDGMGPLQEEYDEDDGLLVEDNQPEE 510
            :..||         .|:    ::||.:.|:
Mosquito   507 KHRDY---------LDQ----IIEDTEKEK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		PHA00733	<308..357	CDD:177301	20/48 (42%)
		C2H2 Zn finger	313..334	CDD:275368	5/20 (25%)
		C2H2 Zn finger	341..362	CDD:275368	10/20 (50%)
		C2H2 Zn finger	370..388	CDD:275368	4/17 (24%)
		C2H2 Zn finger	400..418	CDD:275370	6/17 (35%)
		C2H2 Zn finger	429..447	CDD:275368	5/17 (29%)
AgaP_AGAP003111	XP_312793.5	C2H2 Zn finger	167..188	CDD:275368
		C2H2 Zn finger	196..216	CDD:275368
		C2H2 Zn finger	224..242	CDD:275368
		COG5048	<257..420	CDD:227381	48/158 (30%)
		C2H2 Zn finger	258..278	CDD:275368	3/13 (23%)
		zf-C2H2	288..310	CDD:278523	5/21 (24%)
		C2H2 Zn finger	290..310	CDD:275368	5/19 (26%)
		zf-H2C2_2	303..325	CDD:290200	7/23 (30%)
		C2H2 Zn finger	318..338	CDD:275368	5/19 (26%)
		zf-H2C2_2	330..354	CDD:290200	10/23 (43%)
		C2H2 Zn finger	346..366	CDD:275368	5/19 (26%)
		zf-H2C2_2	359..383	CDD:290200	10/23 (43%)
		C2H2 Zn finger	374..394	CDD:275368	10/20 (50%)
		C2H2 Zn finger	402..423	CDD:275368	5/20 (25%)
		COG5048	428..>484	CDD:227381	13/59 (22%)
		C2H2 Zn finger	431..451	CDD:275368	6/23 (26%)
		C2H2 Zn finger	459..479	CDD:275368	6/19 (32%)
		C2H2 Zn finger	487..505	CDD:275368	4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910