DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF816

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001026835.1	Gene:	ZNF816 / 125893	HGNCID:	26995	Length:	651	Species:	Homo sapiens

Alignment Length:	213	Identity:	71/213 - (33%)
Similarity:	104/213 - (48%)	Gaps:	17/213 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 ECGICPDVMH-KSKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELCTL 318
            :|.:|..:.: |..:..||:.|  .|...|.|..|.:|:.....|..|.|.|.|.:||.|..|..
Human   258 KCDVCGKIFNQKQYIVYHHRCH--TGEKTYKCNECGKTFTQMSSLVCHRRLHTGEKPYKCNECGK 320

  Fly   319 YFSTKQDLRVHNQRRHLEKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKNFSL 383
            .||.|..||.|.:....||.:.|..|||||.:|:.|..|: |.|..::.::|..|.|.:.:..||
Human   321 TFSEKSSLRCHRRLHTGEKPYKCNECGKTFGRNSALVIHK-AIHTGEKPYKCNECGKTFSQKSSL 384

  Fly   384 Q-EHIRNVHMGKRRMLKCPFC-GMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAHK 446
            | .||  :|.|: :..||..| .:..|.:| :.|||| :|..:|:|.|.:|.:.|...||...|:
Human   385 QCHHI--LHTGE-KPYKCEECDNVYIRRSH-LERHRK-IHTGEGSYKCKVCDKVFRSDSYLAEHQ 444

  Fly   447 R------SIQCRSNTRRF 458
            |      ..:|....|.|
Human   445 RVHTGEKPYKCNKCGRSF 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		PHA00733	<308..357	CDD:177301	20/48 (42%)
		C2H2 Zn finger	313..334	CDD:275368	8/20 (40%)
		C2H2 Zn finger	341..362	CDD:275368	10/20 (50%)
		C2H2 Zn finger	370..388	CDD:275368	7/18 (39%)
		C2H2 Zn finger	400..418	CDD:275370	6/18 (33%)
		C2H2 Zn finger	429..447	CDD:275368	6/17 (35%)
ZNF816	NP_001026835.1	KRAB	24..64	CDD:307490
		C2H2 Zn finger	232..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368	5/19 (26%)
		COG5048	283..650	CDD:227381	64/186 (34%)
		C2H2 Zn finger	287..307	CDD:275368	6/19 (32%)
		C2H2 Zn finger	315..335	CDD:275368	8/19 (42%)
		C2H2 Zn finger	343..363	CDD:275368	10/20 (50%)
		C2H2 Zn finger	371..391	CDD:275368	8/21 (38%)
		C2H2 Zn finger	399..419	CDD:275368	8/21 (38%)
		C2H2 Zn finger	427..447	CDD:275368	7/19 (37%)
		C2H2 Zn finger	455..475	CDD:275368	3/8 (38%)
		C2H2 Zn finger	483..503	CDD:275368
		C2H2 Zn finger	511..531	CDD:275368
		C2H2 Zn finger	539..559	CDD:275368
		C2H2 Zn finger	567..587	CDD:275368
		C2H2 Zn finger	595..615	CDD:275368
		C2H2 Zn finger	623..643	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910