DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF705B

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001180559.1	Gene:	ZNF705B / 100132396	HGNCID:	32284	Length:	300	Species:	Homo sapiens

Alignment Length:	278	Identity:	66/278 - (23%)
Similarity:	106/278 - (38%)	Gaps:	86/278 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 QKNNDDDDGSVKEVKPSEKMLEEFKGPRRYMLFDDLIATIVDFDEDSTPLVEFSMISDIMDEKLP 253
            |..|.|.:.::|               :::|:   .:..|:..|..::..:|.|:|.:.     |
Human    74 QDQNPDRESALK---------------KKHMI---SMHPIIRKDTSTSMTMENSLILED-----P 115

  Fly   254 VECGIC-PDVMHKSKLSKHHKTH------------------LVPGTNR--------YACIYCTET 291
            .|.... .|..|.|.:::...||                  |.|...:        |.|..|.:.
Human   116 FEYNDSGEDCTHSSTITQCLLTHSGKKPCVSKQCGKSLRNLLSPKPRKQIHTKGKSYQCNLCEKA 180

  Fly   292 YRDCKYLAGHARRHMGIRPYVCELCTLYFSTKQDLRVHNQRRHLEKEHICEVCGKTFAQNTQLKR 356
            |.:|.||..|...|.|.|||.|.|                            |||.|.|.:.|:|
Human   181 YTNCFYLRRHKMTHTGERPYACHL----------------------------CGKAFTQCSHLRR 217

  Fly   357 HREATHEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMA--RHRKE 419
            | |.||..:|.::|..|.||:.::|:|:.|.| .|:|:    ||..|....:...:.:  |..|.
Human   218 H-EKTHTGERPYKCHQCGKAFIQSFNLRRHER-THLGQ----KCYECDKSGKAFSQSSGFRGNKI 276

  Fly   420 MHLSQGTYVCHLCQEEFT 437
            :|:.:....|.||.:.|:
Human   277 IHIGEKPPACLLCGKAFS 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	3/19 (16%)
		C2H2 Zn finger	285..305	CDD:275368	7/19 (37%)
		PHA00733	<308..357	CDD:177301	11/48 (23%)
		C2H2 Zn finger	313..334	CDD:275368	2/20 (10%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		C2H2 Zn finger	370..388	CDD:275368	7/17 (41%)
		C2H2 Zn finger	400..418	CDD:275370	3/19 (16%)
		C2H2 Zn finger	429..447	CDD:275368	4/9 (44%)
ZNF705B	NP_001180559.1	KRAB	7..66	CDD:214630
		KRAB	7..46	CDD:279668
		COG5048	<116..300	CDD:227381	55/213 (26%)
		C2H2 Zn finger	147..166	CDD:275368	2/18 (11%)
		C2H2 Zn finger	174..194	CDD:275368	7/19 (37%)
		zf-H2C2_2	186..211	CDD:290200	14/52 (27%)
		C2H2 Zn finger	202..222	CDD:275368	11/48 (23%)
		zf-H2C2_2	214..239	CDD:290200	11/25 (44%)
		C2H2 Zn finger	230..250	CDD:275368	8/20 (40%)
		C2H2 Zn finger	258..278	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4954
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050