DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF717

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	XP_011531546.1	Gene:	ZNF717 / 100131827	HGNCID:	29448	Length:	948	Species:	Homo sapiens

Alignment Length:	218	Identity:	69/218 - (31%)
Similarity:	100/218 - (45%)	Gaps:	24/218 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 PVECGICPDVMH-KSKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELC 316
            |.:|..|....| ||.|:.||:||  .|...|.|..|.:|:....||..|.|.|.|.:||.|:.|
Human   400 PYKCIECGKTFHCKSLLTLHHRTH--SGEKPYQCSECGKTFSQKSYLTIHHRTHTGEKPYACDHC 462

  Fly   317 TLYFSTKQDLRVHNQRRHL-EKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAYYKN 380
            ...||.|..|.|| ||.|. ||.:.|..|||.|...:.|:.| :.||..::.::|..|.|.:::.
Human   463 EEAFSHKSRLTVH-QRTHTGEKPYECNECGKPFINKSNLRLH-QRTHTGEKPYECNECGKTFHRK 525

  Fly   381 FSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRKEMHLSQGTYVCHLCQEEFTDISYFDAH 445
            ..|..| :..|.|: :..:|..||...|....:..|:: .|..:..|.|:.|.:.::..||...|
Human   526 SFLTIH-QWTHTGE-KPYECNECGKTFRCKSFLTVHQR-THAGEKPYACNECGKTYSHKSYLTVH 587

  Fly   446 KR---------------SIQCRS 453
            .|               |..|:|
Human   588 HRTHTGEKPYECNECGKSFHCKS 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	8/19 (42%)
		C2H2 Zn finger	285..305	CDD:275368	7/19 (37%)
		PHA00733	<308..357	CDD:177301	21/49 (43%)
		C2H2 Zn finger	313..334	CDD:275368	10/20 (50%)
		C2H2 Zn finger	341..362	CDD:275368	7/20 (35%)
		C2H2 Zn finger	370..388	CDD:275368	5/17 (29%)
		C2H2 Zn finger	400..418	CDD:275370	5/17 (29%)
		C2H2 Zn finger	429..447	CDD:275368	5/17 (29%)
ZNF717	XP_011531546.1	KRAB	56..116	CDD:214630
		KRAB	56..95	CDD:279668
		C2H2 Zn finger	217..237	CDD:275368
		COG5048	343..723	CDD:227381	69/218 (32%)
		C2H2 Zn finger	347..367	CDD:275368
		C2H2 Zn finger	375..395	CDD:275368
		zf-H2C2_2	388..412	CDD:290200	3/11 (27%)
		C2H2 Zn finger	403..423	CDD:275368	8/19 (42%)
		zf-H2C2_2	416..440	CDD:290200	10/25 (40%)
		zf-C2H2	429..451	CDD:278523	8/21 (38%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		zf-H2C2_2	443..468	CDD:290200	11/24 (46%)
		C2H2 Zn finger	459..479	CDD:275368	10/20 (50%)
		zf-H2C2_2	472..494	CDD:290200	12/22 (55%)
		C2H2 Zn finger	487..507	CDD:275368	7/20 (35%)
		zf-H2C2_2	499..524	CDD:290200	7/25 (28%)
		C2H2 Zn finger	515..535	CDD:275368	5/20 (25%)
		zf-H2C2_2	528..552	CDD:290200	7/25 (28%)
		C2H2 Zn finger	543..563	CDD:275368	5/20 (25%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		zf-H2C2_2	583..608	CDD:290200	4/24 (17%)
		COG5048	595..932	CDD:227381	3/16 (19%)
		C2H2 Zn finger	599..619	CDD:275368	3/12 (25%)
		C2H2 Zn finger	627..647	CDD:275368
		zf-H2C2_2	639..664	CDD:290200
		C2H2 Zn finger	655..675	CDD:275368
		zf-H2C2_2	667..692	CDD:290200
		C2H2 Zn finger	683..703	CDD:275368
		zf-H2C2_2	779..801	CDD:290200
		C2H2 Zn finger	794..814	CDD:275368
		C2H2 Zn finger	822..842	CDD:275368
		zf-H2C2_2	835..859	CDD:290200
		C2H2 Zn finger	850..870	CDD:275368
		zf-H2C2_2	863..887	CDD:290200
		C2H2 Zn finger	878..898	CDD:275368
		zf-H2C2_2	891..913	CDD:290200
		zf-C2H2	904..926	CDD:278523
		C2H2 Zn finger	906..926	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910