DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF705E

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001265642.1	Gene:	ZNF705E / 100131539	HGNCID:	33203	Length:	300	Species:	Homo sapiens

Alignment Length:	261	Identity:	63/261 - (24%)
Similarity:	110/261 - (42%)	Gaps:	43/261 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 RSFVSQKNNDDDDGSVKEVKPSEKMLEEFKGPRRYMLFDDLIATIVDFDEDSTPLVEFSMISDIM 248
            |.|: |..|.|.:.::|               :.:|:   .:..|:..|..::..:|.|:|.:.
Human    70 REFL-QDQNPDRESALK---------------KTHMI---SMHPIIRKDAPTSMTMENSLILED- 114

  Fly   249 DEKLPVECGIC-PDVMHKSKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYV 312
                |.||... .|..|.|.:.:...||  .|...|....|.::..:......|.:.|...:.|.
Human   115 ----PFECNDSGEDCTHSSTIIQCLLTH--SGKKPYVSKQCGKSLSNLLSPKPHKQIHTKGKSYQ 173

  Fly   313 CELCTLYFSTKQDLRVHNQRRHLEKEHICEVCGKTFAQNTQLKRHREATHEKKRRFQCEYCQKAY 377
            |.||...::....||........|:.:.|.:|.|.|.|.:.|:|| |.||..:|.::|..|.||:
Human   174 CNLCEKAYTNCFHLRRPKMTHTGERPYTCHLCRKAFTQCSHLRRH-EKTHTGERPYKCHQCGKAF 237

  Fly   378 YKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKM------ARHRKEMHLSQGTYVCHLCQEEF 436
            .::|:|:.|.| .|:|::        ..:|.::.|.      .|..|.:|..:..:.|.||.:.|
Human   238 IQSFNLRRHER-THLGEK--------WYECDNSGKAFSQSSGFRGNKIIHTGEKPHACLLCGKAF 293

  Fly   437 T 437
            :
Human   294 S 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	285..305	CDD:275368	2/19 (11%)
		PHA00733	<308..357	CDD:177301	13/48 (27%)
		C2H2 Zn finger	313..334	CDD:275368	5/20 (25%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		C2H2 Zn finger	370..388	CDD:275368	7/17 (41%)
		C2H2 Zn finger	400..418	CDD:275370	3/23 (13%)
		C2H2 Zn finger	429..447	CDD:275368	4/9 (44%)
ZNF705E	NP_001265642.1	KRAB	7..66	CDD:214630
		C2H2 Zn finger	118..138	CDD:275368	4/19 (21%)
		C2H2 Zn finger	147..166	CDD:275368	2/18 (11%)
		C2H2 Zn finger	174..194	CDD:275368	5/19 (26%)
		C2H2 Zn finger	202..222	CDD:275368	9/20 (45%)
		zf-H2C2_2	214..239	CDD:316026	11/25 (44%)
		C2H2 Zn finger	230..250	CDD:275368	8/20 (40%)
		C2H2 Zn finger	258..278	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4954
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050