DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2116 and ZNF316

DIOPT Version :9

Sequence 1:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001265488.1	Gene:	ZNF316 / 100131017	HGNCID:	13843	Length:	1004	Species:	Homo sapiens

Alignment Length:	225	Identity:	62/225 - (27%)
Similarity:	95/225 - (42%)	Gaps:	35/225 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 PVECGIC-PDVMHKSKLSKHHKTHLVPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELC 316
            |..|..| ...::.|.|::|.:||  .|...:.|..|...:....:||.|.|.|.|.:|:||.:|
Human   718 PHRCADCGKSFVYGSHLARHRRTH--TGERPFPCPECGARFARGSHLAAHVRGHTGEKPFVCGVC 780

  Fly   317 TLYFSTKQDLRVHNQ-----------------------RRHL-----EKEHICEVCGKTFAQNTQ 353
            ...||.:..|..|.:                       .||.     ||.|.|..|||.|..::.
Human   781 GAGFSRRAHLTAHGRAHTGERPYACGECGRRFGQSAALTRHQWAHAEEKPHRCPDCGKGFGHSSD 845

  Fly   354 LKRHREATHEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKRRMLKCPFCGMQCRDAHKMARHRK 418
            .||||. ||..::.|:|..|.:.:.:..:|.:| |..|.|: |...||.||.:......:..|::
Human   846 FKRHRR-THTGEKPFRCADCGRGFAQRSNLAKH-RRGHTGE-RPFPCPECGKRFSQRSVLVTHQR 907

  Fly   419 EMHLSQGTYVCHLCQEEFTDISYFDAHKRS 448
             .|..:..|.|..|...|:..|:...|.::
Human   908 -THTGERPYACANCGRRFSQSSHLLTHMKT 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		PHA00733	<308..357	CDD:177301	19/76 (25%)
		C2H2 Zn finger	313..334	CDD:275368	6/43 (14%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		C2H2 Zn finger	370..388	CDD:275368	4/17 (24%)
		C2H2 Zn finger	400..418	CDD:275370	5/17 (29%)
		C2H2 Zn finger	429..447	CDD:275368	5/17 (29%)
ZNF316	NP_001265488.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..148
		KRAB	158..218	CDD:214630
		COG5048	<345..503	CDD:227381
		C2H2 Zn finger	347..367	CDD:275368
		C2H2 Zn finger	375..395	CDD:275368
		C2H2 Zn finger	403..423	CDD:275368
		C2H2 Zn finger	431..451	CDD:275368
		C2H2 Zn finger	459..479	CDD:275368
		C2H2 Zn finger	487..505	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..574
		C2H2 Zn finger	693..713	CDD:275368
		zf-H2C2_2	705..730	CDD:316026	3/11 (27%)
		C2H2 Zn finger	721..741	CDD:275368	5/19 (26%)
		COG5048	<746..933	CDD:227381	52/190 (27%)
		C2H2 Zn finger	749..769	CDD:275368	6/19 (32%)
		C2H2 Zn finger	777..797	CDD:275368	6/19 (32%)
		C2H2 Zn finger	805..825	CDD:275368	2/19 (11%)
		C2H2 Zn finger	833..853	CDD:275368	9/20 (45%)
		C2H2 Zn finger	861..881	CDD:275368	5/20 (25%)
		C2H2 Zn finger	889..909	CDD:275368	5/20 (25%)
		C2H2 Zn finger	917..937	CDD:275368	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	936..976		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910