Protein Alignment CG2260 and WDR46

DIOPT Version :10

• Sequence 1: NP_572441.1
• Gene: CG2260 / 31732
• FlyBaseID: FBgn0030000
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: XP_054187169.1
• Gene: WDR46 / 9277
• HGNCID: 13923
• Length: 754
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 240/593 - (40%)
• Similarity: 341/593 - (57%)
• Gaps: 62/593 - (10%)

  Fly     4 VTPKG---RPKAKTPYKRYFD----------------GQKDTETGDGDLKHVKVFSKNRQNFTGD 49
            |.||.   :.|.|.| :||::                .:|:.|......|:..:..|:|
Human    11 VPPKKDKLQTKRKKP-RRYWEEETVPTTAGASPGPPRNKKNRELRPQRPKNAYILKKSR------ 68

  Fly    50 FISMINK----TKKPRPQKAP--AKPTKEELEARPKKNPIPKEILDKYSRGEQVQPKGVKTRHFK 108
                |:|    .||||..|.|  .:......:..|...|:|.|::.|:.|.:    |..|..|.|
Human    69 ----ISKKPQVPKKPREWKNPESQRGLSGAQDPFPGPAPVPVEVVQKFCRID----KSRKLPHSK 125

  Fly   109 EQQTRKEVYLEYATEQ-----AARTELLLQETAGQLQADEGETTAEFRQSQIAENVDIQSSAKHF 168
             .:||..:.:..|.|:     |||:||||.|..|.|:.::||.||:..|:.|.|.|||.|:||||
Human   126 -AKTRSRLEVAEAEEEETSIKAARSELLLAEEPGFLEGEDGEDTAKICQADIVEAVDIASAAKHF 189

  Fly   169 NLNM-EFGPYRMRYTKNGRHLLLGGKRGHVAAFDWVTKRLHCEFNAMESVEDVQWLHVPTMYAVA 232
            :||: :|||||:.|::.||||..||:||||||.|||||:|.||.|.||:|.|:::||...:.|||
Human   190 DLNLRQFGPYRLNYSRTGRHLAFGGRRGHVAALDWVTKKLMCEINVMEAVRDIRFLHSEALLAVA 254

  Fly   233 QKSWVYFYDKKGTELHCIKRLNRVNRLDFLPYHFLLAAGNSAGYASWLDVSIGELVGNFNTGLGD 297
            |..|::.||.:|.|||||:|.:||.||:|||:|||||..:..|:.::||||:|::|...|...|.
Human   255 QNRWLHIYDNQGIELHCIRRCDRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGR 319

  Fly   298 IRMLRHNPRNGVLCIGGGRGVVSMWSPKVREPLAKLLCHSTAMSALAVEPKGQYLVTAGLDRAVK 362
            :.::..||.|.|:.:|...|..|:|||.::|||||:|||...:.|:||:..|.|:.|:|||..:|
Human   320 LDVMSQNPYNAVIHLGHSNGTASLWSPAMKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLK 384

  Fly   363 VWDIRMLVHDKPLTHFQLRLPANELDVSQRGMLALSQGTYLETYSDLLSGGGSGDGTRLPYIRQR 427
            ::|:|...  :||:...|...|..|..||||:|....|..:..::.  .|..|......||:..|
Human   385 IFDLRGTY--QPLSTRTLPHGAGHLAFSQRGLLVAGMGDVVNIWAG--QGKASPPSLEQPYLTHR 445

  Fly   428 CDAFVHGLRFCPYEDVLGVSTAKGFQSLLVPGSGEPNFDAMEDNPYETSKQRREHEVHALLEKIP 492
            ....||||:|||:||||||....|..|:||||:||||||.:|.|||.:.|||:|.||.|||||:|
Human   446 LSGPVHGLQFCPFEDVLGVGHTGGITSMLVPGAGEPNFDGLESNPYRSRKQRQEWEVKALLEKVP 510

  Fly   493 PELITLDPQEITGVDAPTLQEKIDAKRKLFHL------KAPRINMKSRHKMKGRGGTAKAARNKQ 551
            .|||.|||:.:..||..:|::  ..|.::..|      |||   .:.:.|.|||..||...:.|:
Human   511 AELICLDPRALAEVDVISLEQ--GKKEQIERLGYDPQAKAP---FQPKPKQKGRSSTASLVKRKR 570

  Fly   552 IVKDAKRK 559
            .|.|.:.:
Human   571 KVMDEEHR 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2260	NP_572441.1	WD40	<177..367	CDD:441893	94/189 (50%)
		WD40 repeat	181..210	CDD:293791	19/28 (68%)
		WD40 repeat	218..253	CDD:293791	16/34 (47%)
		WD40 repeat	256..292	CDD:293791	18/35 (51%)
		WD40 repeat	299..334	CDD:293791	15/34 (44%)
		WD40 repeat	340..376	CDD:293791	13/35 (37%)
		BING4CT	422..500	CDD:198101	48/77 (62%)
WDR46	XP_054187169.1	PTZ00449	<4..>124	CDD:185628	29/127 (23%)
		WD40	<181..390	CDD:441893	106/208 (51%)
		WD40 repeat	199..235	CDD:293791	23/35 (66%)
		WD40 repeat	240..274	CDD:293791	16/33 (48%)
		WD40 repeat	278..314	CDD:293791	18/35 (51%)
		WD40 repeat	323..356	CDD:293791	15/32 (47%)
		WD40 repeat	362..399	CDD:293791	14/38 (37%)
		WD40 repeat	407..443	CDD:293791	11/37 (30%)
		BING4CT	440..517	CDD:462375	47/76 (62%)