Protein Alignment CG2260 and Wdr46

DIOPT Version :10

• Sequence 1: NP_572441.1
• Gene: CG2260 / 31732
• FlyBaseID: FBgn0030000
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: XP_006524760.1
• Gene: Wdr46 / 57315
• MGIID: 1931871
• Length: 636
• Species: Mus musculus
• Alignment Length: 620
• Identity: 250/620 - (40%)
• Similarity: 352/620 - (56%)
• Gaps: 58/620 - (9%)

  Fly     9 RPKAKTPYKRYFDGQ--------------KDTETGDG---DLKHVKVFSKNRQNFTGDFISMINK 56
            :|.::.| :||::.:              |...||:.   ..|...:..|:|            .
Mouse    33 QPPSRKP-RRYWEEETTPAAVATSPGPPRKKARTGESRPPRSKSAHIAQKSR------------F 84

  Fly    57 TKKPRPQK-AP--AKPTKEELEAR---PKKNPIPKEILDKYSRGEQVQPKGVKTRHFKEQQTRK- 114
            :|||...| ||  .||.:....|:   |...|.|.|...|:.|.:    |.....|.|.:...|
Mouse    85 SKKPPISKTAPDWKKPQRTLSGAQDPFPGPVPAPLEEARKFCRID----KSKTLPHSKPKTQSKL 145

  Fly   115 ---EVYLEYATEQAARTELLLQETAGQLQADEGETTAEFRQSQIAENVDIQSSAKHFNLNM-EFG 175
               |...|.|:.:|||.||||.|..|.|..::||.||:..|:.|.|.|||.|:||||:||: :||
Mouse   146 EKAEAQEEEASVRAARAELLLAEEPGFLVGEDGEDTAKILQTDIVEAVDIASAAKHFDLNLRQFG 210

  Fly   176 PYRMRYTKNGRHLLLGGKRGHVAAFDWVTKRLHCEFNAMESVEDVQWLHVPTMYAVAQKSWVYFY 240
            |||:.|::.||||.|||:||||||.|||||:|.||.|.||:|.|:.:||...:.||||..|:|.|
Mouse   211 PYRLNYSRTGRHLALGGRRGHVAALDWVTKKLMCEINVMEAVRDIHFLHSEALLAVAQNRWLYIY 275

  Fly   241 DKKGTELHCIKRLNRVNRLDFLPYHFLLAAGNSAGYASWLDVSIGELVGNFNTGLGDIRMLRHNP 305
            |.:|.|||||:|.:||.||:|||:|||||..:..|:.::||||:|::|...|...|.:.::..||
Mouse   276 DNQGIELHCIRRCDRVTRLEFLPFHFLLATTSETGFLTYLDVSVGKIVTALNVRAGRLSVMAQNP 340

  Fly   306 RNGVLCIGGGRGVVSMWSPKVREPLAKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWDIRMLV 370
            .|.|:.:|...|.||:|||.|:|||||:|||...:.|:||:..|.|:.|:|||..:|::|:|...
Mouse   341 YNAVIHLGHSNGTVSLWSPAVKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRGTF 405

  Fly   371 HDKPLTHFQLRLPANELDVSQRGMLALSQGTYLETYSDLLSGGGSGDGTRLPYIRQRCDAFVHGL 435
              :||:...|...|..|..||||:|....|..:..::.  .|..|......||:..|....||||
Mouse   406 --QPLSSRTLPQGAGHLAFSQRGLLVAGMGDVVNIWAG--QGKASPPSLEQPYLTHRLSGHVHGL 466

  Fly   436 RFCPYEDVLGVSTAKGFQSLLVPGSGEPNFDAMEDNPYETSKQRREHEVHALLEKIPPELITLDP 500
            :|||:||||||..:.||.|:||||:.|||||.:|:|||.:.|||:|.||.|||||:|.|||.|:|
Mouse   467 QFCPFEDVLGVGHSGGFTSMLVPGAAEPNFDGLENNPYRSRKQRQEWEVKALLEKVPAELICLNP 531

  Fly   501 QEITGVDAPTL-QEKIDAKRKLFHLKAPRINMKSRHKMKGRGGTAKAARNKQIVKDAKRKEFIAE 564
            :.:..||..|| |:|.:...:|.:....:...:.:.|.|||..||...:.|:.|.|.:.::.:.:
Mouse   532 RALAEVDVVTLEQQKKERIERLGYDPDAKAAFQPKAKQKGRSSTASLVKRKKKVMDQEHRDKVRQ 596

  Fly   565 VREAKKNVIKQHTADEVGAKGKAKTKAPRSVLDRF 599
            ..|.::...||..|...||:        .|.||||
Mouse   597 SLEQQQQKKKQDMAMPPGAR--------PSALDRF 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2260	NP_572441.1	WD40	<177..367	CDD:441893	98/189 (52%)
		WD40 repeat	181..210	CDD:293791	20/28 (71%)
		WD40 repeat	218..253	CDD:293791	17/34 (50%)
		WD40 repeat	256..292	CDD:293791	18/35 (51%)
		WD40 repeat	299..334	CDD:293791	17/34 (50%)
		WD40 repeat	340..376	CDD:293791	13/35 (37%)
		BING4CT	422..500	CDD:198101	48/77 (62%)
Wdr46	XP_006524760.1	WD40	<194..403	CDD:441893	110/208 (53%)
		WD40 repeat	212..248	CDD:293791	24/35 (69%)
		WD40 repeat	253..287	CDD:293791	17/33 (52%)
		WD40 repeat	291..327	CDD:293791	18/35 (51%)
		WD40 repeat	334..369	CDD:293791	17/34 (50%)
		WD40	368..>462	CDD:475233	31/97 (32%)
		WD40 repeat	375..412	CDD:293791	14/38 (37%)
		WD40 repeat	420..460	CDD:293791	12/41 (29%)
		BING4CT	453..530	CDD:462375	47/76 (62%)