DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2260 and wdr46

DIOPT Version :9

Sequence 1:	NP_572441.1	Gene:	CG2260 / 31732	FlyBaseID:	FBgn0030000	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_956917.1	Gene:	wdr46 / 393596	ZFINID:	ZDB-GENE-040426-1264	Length:	583	Species:	Danio rerio

Alignment Length:	612	Identity:	252/612 - (41%)
Similarity:	353/612 - (57%)	Gaps:	63/612 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RPKAKTPYKRYFDGQKDTETGDGDLKHVKVFSKNRQNFTGDFISMINKTKKPRPQKAPAKPTKEE 73
            |...|.|.|||::..::||..    |..:..||:.|.            :||..:|.    .|||
Zfish    14 RKAKKKPAKRYWEETENTEQN----KPTEEESKDEQK------------QKPHTEKR----KKEE 58

  Fly    74 --LEAR----PKKNPIPKEILDKYSRGEQVQPKGVKTRHFKEQQTRKEVYLEYATEQAARTELLL 132
              |..:    |.:.|||::.|..:.||::.:.........|...|..|...|.|.:||||..|||
Zfish    59 RLLSGKEDPFPGEKPIPQKQLRTFQRGQKHKVPARAGPKLKHAITSSESLSELAQKQAARYGLLL 123

  Fly   133 QETAGQLQADEGETTAEFRQSQIAENVDIQSSAKHFNLNM-EFGPYRMRYTKNGRHLLLGGKRGH 196
            .|.||.|:.|:||.|....|..||:.|||.|.||:|||:: :|||||:.|::.||||||||:|||
Zfish   124 PEDAGFLEGDDGEDTCTIAQDDIADAVDITSGAKYFNLHLSQFGPYRLDYSRTGRHLLLGGRRGH 188

  Fly   197 VAAFDWVTKRLHCEFNAMESVEDVQWLHVPTMYAVAQKSWVYFYDKKGTELHCIKRLNRVNRLDF 261
            ||.|||.||.|.||.|.||:|.|::|||...|:|||||.|:|.||.||.|.||||:.|.|.|:.|
Zfish   189 VACFDWQTKHLMCEMNVMETVNDIKWLHTEAMFAVAQKKWLYIYDSKGVEFHCIKKFNDVLRMQF 253

  Fly   262 LPYHFLLAAGNSAGYASWLDVSIGELVGNFNTGLGDIRMLRHNPRNGVLCIGGGRGVVSMWSPKV 326
            ||||||||..::.|:..:||||||:.:....|..|.:.::..||.|.::.:|...|.||:|||..
Zfish   254 LPYHFLLATASATGFLQYLDVSIGKEIAAICTKSGRLNVMTQNPYNAIIHLGHTSGTVSLWSPNQ 318

  Fly   327 REPLAKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWDIRMLVHDKPLTHFQLRLPANELDVSQ 391
            :|||.|:|||..|:.::||:..|.|:||:||||.:||:|||..   ||.....|...|:.|.:||
Zfish   319 KEPLVKMLCHRGAVHSVAVDKTGTYMVTSGLDRKLKVYDIRAF---KPFHSSFLPAGASCLSLSQ 380

  Fly   392 RGMLALSQGTYLETYSDLLSGGGSGDGTRLPYIRQRCDAFVHGLRFCPYEDVLGVSTAKGFQSLL 456
            ||:|:.:.|..::.|.::   .||...:: ||:..|....|.|:.:||:|||||:...:||.|::
Zfish   381 RGLLSAATGDVVQVYQNV---WGSTPVSK-PYMAHRLRGQVCGVAYCPFEDVLGIGHGQGFTSMI 441

  Fly   457 VPGSGEPNFDAMEDNPYETSKQRREHEVHALLEKIPPELITLDPQEITGVDAPTLQ----EKID- 516
            |||:|||||||::.|||.::|||:|.||.|||||:.||||.|||..::.||..:.:    |:::
Zfish   442 VPGAGEPNFDALDTNPYRSAKQRQEWEVKALLEKVQPELIGLDPGLLSKVDQASFEQRHKERVEV 506

  Fly   517 ------AKRKLFHLKAPRINMKSRHKMKGRGGT-AKAARNKQIVKDAKRKEFIAEVREAKKNVIK 574
                  ||:|          .|.|.:.|||... |...|.:::..:.:|.|....|.|..|...:
Zfish   507 MGFDPLAKQK----------FKPRMRKKGRSSAGAVEKRKRKVAHEDQRDEIRQTVEEKMKRQKE 561

  Fly   575 Q-HTADEVGAKGKAKTKAPRSVLDRFK 600
            | ..:||      .|....:|.|||||
Zfish   562 QKERSDE------RKELEKKSALDRFK 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2260	NP_572441.1	WD40	177..398	CDD:295369	113/220 (51%)
		WD40	<181..371	CDD:225201	101/189 (53%)
		WD40 repeat	181..210	CDD:293791	20/28 (71%)
		WD40 repeat	218..253	CDD:293791	21/34 (62%)
		WD40 repeat	256..292	CDD:293791	18/35 (51%)
		WD40 repeat	299..334	CDD:293791	14/34 (41%)
		WD40 repeat	340..376	CDD:293791	17/35 (49%)
		BING4CT	422..500	CDD:198101	44/77 (57%)
wdr46	NP_956917.1	WD40	169..390	CDD:295369	113/223 (51%)
		WD40 repeat	169..202	CDD:293791	22/32 (69%)
		WD40	<172..370	CDD:225201	103/200 (52%)
		WD40 repeat	210..245	CDD:293791	21/34 (62%)
		WD40 repeat	248..284	CDD:293791	18/35 (51%)
		WD40 repeat	291..326	CDD:293791	14/34 (41%)
		WD40 repeat	332..365	CDD:293791	17/35 (49%)
		WD40 repeat	373..414	CDD:293791	14/44 (32%)
		BING4CT	407..484	CDD:285375	43/76 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595533
Domainoid	1	1.000	320	1.000	Domainoid score	I1215
eggNOG	1	0.900	-	-		E1_KOG1272
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3981
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1715
OMA	1	1.010	-	-		QHG55311
OrthoDB	1	1.010	-	-		D222308at33208
OrthoFinder	1	1.000	-	-		FOG0005051
OrthoInspector	1	1.000	-	-		oto40802
orthoMCL	1	0.900	-	-		OOG6_102360
Panther	1	1.100	-	-	LDO	PTHR14085
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1624
SonicParanoid	1	1.000	-	-		X3576
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840