Protein Alignment CG2260 and Wdr46

DIOPT Version :10

• Sequence 1: NP_572441.1
• Gene: CG2260 / 31732
• FlyBaseID: FBgn0030000
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_997656.1
• Gene: Wdr46 / 309628
• RGDID: 2209
• Length: 609
• Species: Rattus norvegicus
• Alignment Length: 560
• Identity: 237/560 - (42%)
• Similarity: 331/560 - (59%)
• Gaps: 36/560 - (6%)

  Fly    58 KKPRPQKAPAKPTKEELEARPKKN------------PIPKEILDKYSRGEQVQPKGVKTRHFK-- 108
            :|||..|.|..|.......:|::.            |.|.|:..|:.|.:    |..|..|.|
  Rat    66 QKPRFSKKPPIPKNASDWKKPQRTLSGAQDPFPGPVPAPLEVARKFCRID----KSKKLPHSKPK 126

  Fly   109 --EQQTRKEVYLEYATEQAARTELLLQETAGQLQADEGETTAEFRQSQIAENVDIQSSAKHFNLN 171
              .|..:.|...|.|:.:|||.||||.|..|.|..::||.||:..|:.|.|.|||.|:||||:||
  Rat   127 TQSQLEKAEAQEEEASVRAARAELLLAEEPGFLVGEDGEDTAKILQTDIVEAVDISSAAKHFDLN 191

  Fly   172 M-EFGPYRMRYTKNGRHLLLGGKRGHVAAFDWVTKRLHCEFNAMESVEDVQWLHVPTMYAVAQKS 235
            : :|||||:.|::.||||.|||:||||||.|||||:|.||.|..|:|.|:.:||...:.||||..
  Rat   192 LRQFGPYRLNYSRTGRHLALGGRRGHVAALDWVTKKLMCEINVTEAVRDIHFLHSEALLAVAQNR 256

  Fly   236 WVYFYDKKGTELHCIKRLNRVNRLDFLPYHFLLAAGNSAGYASWLDVSIGELVGNFNTGLGDIRM 300
            |:|.||.:|.|||||:|.:||.||:|||:|||||..:..|:.::||||:|::|...|...|.:.:
  Rat   257 WLYIYDNQGIELHCIRRCDRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVTALNARAGRLNV 321

  Fly   301 LRHNPRNGVLCIGGGRGVVSMWSPKVREPLAKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWD 365
            :..||.|.|:.:|...|.||:|||.::|||||:|||...:.|:.|:..|.|:.|:|||..:|::|
  Rat   322 MAQNPYNAVIHLGHSNGTVSLWSPAMKEPLAKILCHRGGVRAVGVDSTGTYMATSGLDHQLKIFD 386

  Fly   366 IRMLVHDKPLTHFQLRLPANELDVSQRGMLALSQGTYLETYSDLLSGGGSGDGTRLPYIRQRCDA 430
            :|...  :||:...|...|..|..||||:|....|..:..::.  .|.||......||:..|...
  Rat   387 LRGTF--QPLSSRTLPQGAGHLAFSQRGLLVAGMGDVVNIWAG--QGKGSPPSLEQPYLTHRLSG 447

  Fly   431 FVHGLRFCPYEDVLGVSTAKGFQSLLVPGSGEPNFDAMEDNPYETSKQRREHEVHALLEKIPPEL 495
            .||||:|||:||||||..:.|..|:||||:.|||||.:|.|||.:.|||:|.||.|||||:|.||
  Rat   448 NVHGLQFCPFEDVLGVGHSGGITSMLVPGAAEPNFDGLESNPYRSRKQRQEWEVKALLEKVPAEL 512

  Fly   496 ITLDPQEITGVDAPTL-QEKIDAKRKLFHLKAPRINMKSRHKMKGRGGTAKAARNKQIVKDAKRK 559
            |.|||:.:..||..|| |:|.:...:|.:....:...:.:.|.|||..||...:.|:.|.|.:.:
  Rat   513 ICLDPRALAEVDVTTLEQQKKERIERLGYDPDAKAAFQPKAKQKGRSSTASLVKRKKKVMDQEHR 577

  Fly   560 EFIAEVREAKKNVIKQHTADEVGAKGKAKTKAPRSVLDRF 599
            :   :||::.:...|:       .:.|||..|..|.||||
  Rat   578 D---KVRQSLEQQQKK-------KQDKAKPGAHPSALDRF 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2260	NP_572441.1	WD40	<177..367	CDD:441893	95/189 (50%)
		WD40 repeat	181..210	CDD:293791	20/28 (71%)
		WD40 repeat	218..253	CDD:293791	17/34 (50%)
		WD40 repeat	256..292	CDD:293791	18/35 (51%)
		WD40 repeat	299..334	CDD:293791	16/34 (47%)
		WD40 repeat	340..376	CDD:293791	12/35 (34%)
		BING4CT	422..500	CDD:198101	47/77 (61%)
Wdr46	NP_997656.1	PTZ00449	<6..>126	CDD:185628	16/63 (25%)
		WD40	<198..389	CDD:441893	95/190 (50%)
		WD40 repeat	198..234	CDD:293791	24/35 (69%)
		WD40 repeat	239..273	CDD:293791	17/33 (52%)
		WD40 repeat	277..313	CDD:293791	18/35 (51%)
		WD40 repeat	320..355	CDD:293791	16/34 (47%)
		WD40	354..>447	CDD:475233	31/96 (32%)
		WD40 repeat	361..398	CDD:293791	13/38 (34%)
		WD40 repeat	406..442	CDD:293791	12/37 (32%)
		BING4CT	439..516	CDD:462375	46/76 (61%)