DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2260 and wdr46

DIOPT Version :9

Sequence 1:	NP_572441.1	Gene:	CG2260 / 31732	FlyBaseID:	FBgn0030000	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	XP_002938714.2	Gene:	wdr46 / 100486235	XenbaseID:	XB-GENE-489373	Length:	592	Species:	Xenopus tropicalis

Alignment Length:	620	Identity:	253/620 - (40%)
Similarity:	364/620 - (58%)	Gaps:	69/620 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KAKTPYKRYFDGQKDTETGDGDLKHVKVFSKNRQNFTGDFISMINKTKKPR-------PQKAPAK 68
            |||...|||::.|.:.:|..|::....                 |:|:.|:       .||:..|
Frog    11 KAKNKVKRYYEEQDEHQTPGGNVDGTD-----------------NQTESPKDVPQLPTEQKSRRK 58

  Fly    69 PTKEELEARPK------KNP------IPKEILDKYSR------GEQVQPKGVKTRHFKEQQTRKE 115
            ..|.:|:....      |:|      :|:..|.||.|      |.:..|  ....|.|.|:..
Frog    59 RVKGDLKKSGSNFISGAKDPFPGSVSVPENRLLKYERARKSKLGRKYSP--YVQHHLKTQEND-- 119

  Fly   116 VYLEYATEQAARTELLLQETAGQLQADEGETTAEFRQSQIAENVDIQSSAKHFNLNM-EFGPYRM 179
              ::.|..||||.::||.|..|.|:.|||:.|....|..|||.|||.|::||||||: :|||||:
Frog   120 --VQTALGQAARHDILLPEEEGFLEGDEGQDTCTITQEDIAEMVDITSASKHFNLNLNQFGPYRI 182

  Fly   180 RYTKNGRHLLLGGKRGHVAAFDWVTKRLHCEFNAMESVEDVQWLHVPTMYAVAQKSWVYFYDKKG 244
            .|.:|||||||.|:|||:|:.:|.:|:|.||.|.||:|.||:|||..||||.||:.|:|.||.:|
Frog   183 NYARNGRHLLLAGQRGHLASLEWQSKKLICEMNVMETVNDVKWLHTHTMYAAAQRRWLYIYDSQG 247

  Fly   245 TELHCIKRLNRVNRLDFLPYHFLLAAGNSAGYASWLDVSIGELVGNFNTGLGDIRMLRHNPRNGV 309
            .||||||:.|.|.|::|||||||||..:|.|:..:||||:|:.:.......|.:.::..||.|.|
Frog   248 VELHCIKKFNDVLRMEFLPYHFLLATCSSTGFLQYLDVSVGKEIAATCVKSGRLNVMCQNPNNAV 312

  Fly   310 LCIGGGRGVVSMWSPKVREPLAKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWDIRMLVHDKP 374
            :.:|...|.||:|||.::|||.|:|||..|:.||:|:..|.|:.::||||.:.::|:|..   :|
Frog   313 IHLGHHNGTVSLWSPSMKEPLVKMLCHRGAVRALSVDKTGMYMASSGLDRKLTIFDMRTY---RP 374

  Fly   375 LTHFQLRLPANELDVSQRGMLALSQGTYLETYSDLLSGGGSGDGTRLPYIRQRCDAFVHGLRFCP 439
            ||...|.|.|..|..||:|:||...|..::.|.|.     |....|.||:..:....:|||:|||
Frog   375 LTSCLLPLGAGSLCHSQKGLLAAGTGDIVQVYKDT-----SVSPPRSPYMCLQVKGPIHGLQFCP 434

  Fly   440 YEDVLGVSTAKGFQSLLVPGSGEPNFDAMEDNPYETSKQRREHEVHALLEKIPPELITLDPQEIT 504
            :||:||:....||.|::|||:||.||||||.|||||.|||:|.||.||||||.||||||||.::.
Frog   435 FEDILGIGHGGGFTSMIVPGAGEANFDAMECNPYETKKQRQEWEVKALLEKIQPELITLDPTQLG 499

  Fly   505 GVDAPTLQEKIDAKRKLF----HLKAPRINMKSRHKMKGRGGTAKAARNKQIVKDAKRKEFIAEV 565
            .|||.|:::|...|.:..    |.|.|.:   .|||:|||..:|...:.|:.|...:::|   ::
Frog   500 EVDAITMEQKHKEKVERLGFDPHEKTPFV---PRHKLKGRSSSANLLKRKKKVAHEEQRE---QI 558

  Fly   566 REAKKNVIKQHTADEVGAKGKAKTKAPRSVLDRFK 600
            |::.|  :|:...::..::...::.|.:|.|||||
Frog   559 RKSIK--VKEKQKEQKKSREGIRSPAEQSALDRFK 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2260	NP_572441.1	WD40	177..398	CDD:295369	108/220 (49%)
		WD40	<181..371	CDD:225201	94/189 (50%)
		WD40 repeat	181..210	CDD:293791	16/28 (57%)
		WD40 repeat	218..253	CDD:293791	22/34 (65%)
		WD40 repeat	256..292	CDD:293791	18/35 (51%)
		WD40 repeat	299..334	CDD:293791	15/34 (44%)
		WD40 repeat	340..376	CDD:293791	12/35 (34%)
		BING4CT	422..500	CDD:198101	49/77 (64%)
wdr46	XP_002938714.2	WD40	<187..447	CDD:225201	122/267 (46%)
		WD40 repeat	221..256	CDD:293791	22/34 (65%)
		WD40 repeat	259..294	CDD:293791	18/34 (53%)
		WD40 repeat	302..337	CDD:293791	15/34 (44%)
		WD40 repeat	343..377	CDD:293791	13/36 (36%)
		BING4CT	417..495	CDD:198101	49/77 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	300	1.000	Domainoid score	I1417
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3981
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1654
OMA	1	1.010	-	-		QHG55311
OrthoDB	1	1.010	-	-		D222308at33208
OrthoFinder	1	1.000	-	-		FOG0005051
OrthoInspector	1	1.000	-	-		oto103018
Panther	1	1.100	-	-	LDO	PTHR14085
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1624
SonicParanoid	1	1.000	-	-		X3576
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110