DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2258 and LDB17

DIOPT Version :9

Sequence 1:	NP_001285000.1	Gene:	CG2258 / 31729	FlyBaseID:	FBgn0029997	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_010135.1	Gene:	LDB17 / 851409	SGDID:	S000002305	Length:	491	Species:	Saccharomyces cerevisiae

Alignment Length:	417	Identity:	91/417 - (21%)
Similarity:	161/417 - (38%)	Gaps:	131/417 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 EEDIIQFLEELVEIL----INADES------ISCYEMSCDQYQMFIN---------LV----QYY 535
            :::||:|.|:...|.    .|.|||      ::..:.:.|.|::|||         |:    ..:
Yeast    15 QDEIIEFWEKTESIANIPKENLDESHVNSSLVAYLKFATDSYKVFINTDRDLYRMSLILLESSLF 79

  Fly   536 QMETRWSIKRL--LLKTFTAACHLDYIIVDILL----TSVLPLEIV----------EDMKTHFSN 584
            :.:..:.:.:|  ||.......::.:|||.|||    .:|..|||:          ..:.|.|:.
Yeast    80 EFKKEFCLSKLQSLLNIDLLEMNMKFIIVYILLCEAKKNVYSLEIMLKFQGFTVFYNTLYTQFAY 144

  Fly   585 L-----------------------------------------DRFKQL-VKMLTIIFSLGQPMPV 607
            |                                         |..||: ..::.::|.:
Yeast   145 LSKYGKERTVASKHQYNSNNSSTGTSLDSLDRSLTDIDLGIIDEMKQISTVLMDLLFQI------ 203

  Fly   608 NHQDYLGVHFAS-------FLLEIVEGNNPEVLVDMV----IALILAFNQQF---------SEHT 652
              ..|.....|:       |:..::|....:.:.||.    ..|:||.|:|:         ....
Yeast   204 --MKYCKCVIANLQIVDDFFVYYMMESMRSDTMDDMFNNAEFKLLLALNEQYMMFAKEYDIENKV 266

  Fly   653 YNVIIEGMQNLPSAKVFTEKLLLLLNREDDPTRLLKHPNEHMNTVLRMFIDIFSHPDTAGM--FY 715
            |..:|.|    ..::.|||.|||..||..||      |.:.|...: :::.:....|.:.|  ||
Yeast   267 YKYLING----SVSRCFTELLLLKFNRASDP------PLQIMMCKI-IYLILTPRGDYSPMNFFY 320

  Fly   716 TNDIKVLIDIVVRQLSDL-DAGSTTRPCYLELCRRILRNTNYQEHQHRKHDLMKIFTRIFCEETE 779
            |||::||||:::|:|.:: :.....|...|.:...:|:||...:..:||.||.|:...:...:..
Yeast   321 TNDLRVLIDVLIRELQNISEDEEVLRNTLLRVLIPLLKNTQLSKTHYRKDDLNKLLNYLSTLDNI 385

  Fly   780 CSAS----DQQ----LVREIANEFPQL 798
            |..|    :.|    |.|:...:.|.|
Yeast   386 CVDSPALHEHQVTVALSRKCLQQIPWL 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2258	NP_001285000.1	SH3_SPIN90	1..55	CDD:212783
		PHA03420	108..>188	CDD:177648
		DUF2013	631..766	CDD:286514	42/150 (28%)
LDB17	NP_010135.1	DUF2013	235..372	CDD:401404	42/147 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346843
Domainoid	1	1.000	55	1.000	Domainoid score	I2740
eggNOG	1	0.900	-	-		E1_KOG4035
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006257
OrthoInspector	1	1.000	-	-		oto100003
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13357
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5829
SonicParanoid	1	1.000	-	-		X4538
TreeFam	0	0.000	Not matched by this tool.
	9	8.870