Protein Alignment CG2258 and NCKIPSD

DIOPT Version :10

• Sequence 1: NP_572439.1
• Gene: CG2258 / 31729
• FlyBaseID: FBgn0029997
• Length: 801
• Species: Drosophila melanogaster
• Sequence 2: NP_057537.1
• Gene: NCKIPSD / 51517
• HGNCID: 15486
• Length: 722
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 111/599 - (18%)
• Similarity: 201/599 - (33%)
• Gaps: 195/599 - (32%)

  Fly   391 KEKPKEPEPEEDAWAQFKRMTEKVST----------AVKSTESTLKNLEETSAANDIKDESYLAN 445
            ||:.::....|:...:.|.:..||..          .:|:|::.:..|:|..|..|.:.|...:.
Human   232 KEQEEKQRKAEELLQELKHLKIKVEELENERNQYEWELKATKAEVAQLQEQVALKDAEIERLHSQ 296

  Fly   446 VGGSQGFVNESTQK--EIQRL------------TEEKKMEKLQ---KKKLKQQGKKAATPTLEPD 493
            :..|....::..::  ||.||            .:::::|:|.   .|.|:.  |:....|..|.
Human   297 LSRSAALHSDHAERDQEIHRLKMGMETLLVANEDKDRRIEELTGLLNKYLRV--KEIVMATQGPS 359

  Fly   494 EEDAMDRAAQELAMKMASMRSDMADW----KAPEMIPVKEIKKAPEIRRVDSASAIPP------- 547
            |        :.|::....:......|    |:||.:|.:||..     |..|.:..||
Human   360 E--------RTLSINEDEIEGSFRKWNTTNKSPEEVPKQEISP-----RCSSPTPGPPPLPQKSL 411

  Fly   548 -----RKRS-SIKDVQQDSGGSL----ELPPHLAAPQDS---------------IAPNPKGDHAP 587
                 :|.| |::|::::||...    :|.| :..|:||               ....|.|:.|.
Human   412 ESRAQKKLSCSLEDLRRESGDKCVDGNQLSP-VGEPKDSSFLAEQKYPTLPGKLSGATPNGEAAK 475

  Fly   588 DDPILSAPAWADFETSEPMLPPSESGFFSNKDASNEG--------GVSRDATDDPFVTTVASSEK 644
            ..|..|             |.|..||  |::...|.|        |.:....:|  :.:.|||..
Human   476 SPPTAS-------------LQPDSSG--SSQPKLNRGWSVSAPVLGDTEGGWED--IVSSASSGT 523

  Fly   645 RSSFVADPFAPQQAALIDESYDPFAVVAVEEVVAMAKAKAEQAA---ANAENEDDFYNG------ 700
            .||       ||.....|....|..:...     ..|.:..|:.   .:|....:|..|
Human   524 ESS-------PQSPVTPDGKRSPKGIKKF-----WGKIRRTQSGNFNTDAPGMAEFRRGGLRATA 576

  Fly   701 --RQSPTLSTPTP--EGGSPISQ---QRPNAFEDDFKCAELT-----------GLDTPTPLYDED 747
              |.|.|..|...  :..:|.:|   :|...:.:||...:..           .|.|.||    .
Human   577 GPRLSRTRDTKGQKCDANAPFAQWSTERVCTWMEDFGLGQYVIFARQWVTSGHTLLTATP----Q 637

  Fly   748 DSQPLTDFIPKFDGDGWDLMVRHPIKKK----------------SFMAERCWKPCYVRLHGLTLY 796
            |.:.             :|.::||:.:|                |.:.:..|...::...||..|
Human   638 DMEK-------------ELGIKHPLHRKKLVLAVKAINAKQEETSALLDHIWVTRWLDDIGLPQY 689

  Fly   797 ---LYNDKKDAQPIQELLLQATYSLSDTTLQAYDVYGKIHTVKLQFVVYKEKVG--------IRP 850
               .:..:.|.:.:|.|.:.....|..|:        ::|.:.::..::...|.        .||
Human   690 KDQFHESRVDGRMLQYLTVNDLLFLKVTS--------QLHHLSIKCAIHVLHVNKFNPNCLHRRP 746

  Fly   851 GQISRLVDGHITKY 864
            ...|.|....:.::
Human   747 ADESNLSPSEVVQW 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2258	NP_572439.1	SH3_SPIN90	1..55	CDD:212783
		SPIN90_LRD	631..766	CDD:462796	29/161 (18%)
NCKIPSD	NP_057537.1	SH3_SPIN90	1..54	CDD:212783
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..122
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..286		11/53 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	175..192
		SPIN90_LRD	<570..683	CDD:462796	21/129 (16%)