DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2258 and Nckipsd

DIOPT Version :9

Sequence 1:	NP_001285000.1	Gene:	CG2258 / 31729	FlyBaseID:	FBgn0029997	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_001380856.1	Gene:	Nckipsd / 301009	RGDID:	1311323	Length:	714	Species:	Rattus norvegicus

Alignment Length:	829	Identity:	245/829 - (29%)
Similarity:	379/829 - (45%)	Gaps:	151/829 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKALYDFQAVYPKTISFDEGEYFILYQTSARQRNWWQVV-SMKGNIGFVPSNYVMKIKVEHDFL 64
            |.:|||.|::..|..::|..||.|::.:.|:  .:||... :..|..|:||..|:.:::.....:
  Rat     1 MYRALYAFRSAEPNAMAFAAGETFLVLERSS--THWWLAARARSGETGYVPPAYLHRLQGMEQDV 63

  Fly    65 ISFLNSSIESLEKCT-------DHEINGIMSKDELLDRLREKKHTMERLYAESSERDGDSSLSYS 122
            :..::.:||::....       ..|..|::.|     .:..:|.|:        .|.|.|:.|.|
  Rat    64 LQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQK-----LIHHRKETL--------SRRGTSAASAS 115

  Fly   123 HSYSDKGSHRHSHPHPTQSQTQLHSQ---------HRQHSPPPSGGSVGSQRLDMSKKSMSSPAV 178
            ........|        ...|.:..|         .||||.|                  ||..:
  Rat   116 VMTPSTSDH--------HLDTAVSRQPNGVCRTGFERQHSLP------------------SSEHL 154

  Fly   179 GSSCGLPQNQGMIESPSMGSMQFQGSSCTIQTPQQQQPLPAPPAPAPSPSAASATPTAASTSKAA 243
            |:...|.|                      ..||.::..||.|.|........|...:.|..:.|
  Rat   155 GTDGALYQ----------------------VPPQPRRAAPATPPPPVKRRDREALVISGSGGRTA 197

  Fly   244 T---GGDVAQDNSITSEPSETTTTTTTTSEDVVTTYKETSQMSTSQQHKPQNGSTASASISASAS 305
            .   |..|:..:|::|           ||.|.:.|....|::..|....|......||..:.|.:
  Rat   198 VPSGGSSVSSGSSVSS-----------TSMDTLYTGSSPSELGPSCSPTPPPVPRRSAHTTVSQA 251

  Fly   306 ASALRSNGGNGKANGSATALHQELQQEEADSAPDKSDDASAVQSDDGCPANGDSADNSQALDSID 370
                                     |.....||.....|..|.::     ...:.|:.:|||::
  Rat   252 -------------------------QPSPSKAPSPEPPAEEVAAE-----TNSAPDDLEALDAL- 285

  Fly   371 SPSHRQRGLSLGRIEEGATGGGQLKVESSDVYQIVDALRRNTNLSFDLSCEALRVVLTSLEQLYN 435
            ||...:        |:.||   :..|..:...::::.:||||.||.:|...|:.||:..: |...
  Rat   286 SPETTE--------EKPAT---ETVVPRTIGAELMELVRRNTGLSHELCRVAIGVVVGHI-QASV 338

  Fly   436 GAINPYLEAVAVH-VTGK-VATPKELLGITHDAKRLQYLFAQLADCKNDTEQRTWMLYEDEEDII 498
            .|.:|.:|.|.:. |.|| ::|......:.||.:||:.:||.||..|:|.:||:|.|||||:.|.
  Rat   339 PASSPVMEQVLLSLVEGKDLSTALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEDVIR 403

  Fly   499 QFLEELVEILINADESISCYEMSC--DQYQMFINLVQYYQMETRWSIKRLLLKTFTAACHLDYII 561
            .:||||:.||.:||..: |.:| |  ..::..:.||.|||||.|.|::.||||.|.|.|.||..|
  Rat   404 CYLEELLHILTDADPEV-CKKM-CKRSDFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAI 466

  Fly   562 VDILLTSVLPLEIVEDMKTHFSNLDRFKQLVKMLTIIFSLGQPMPVNHQDYLGVHFASFLLEIVE 626
            :..|::||||:|:..||:|...:..:......:|.::||:|:.:|..|.::||..||.|||.|||
  Rat   467 ISTLVSSVLPVELARDMQTDTQDHQKLCYSALVLAMVFSMGEAVPYAHYEHLGTPFAQFLLSIVE 531

  Fly   627 GNNP----EVLVDMVIALILAFNQQFSEHTYNVIIEGMQNLPSAKVFTEKLLLLLNREDDPTRLL 687
            ...|    |.|.|:.:.|:||.|...:....|||:..:....:.|:|:|||||||||.|||.|:.
  Rat   532 DGLPLDATEQLPDLCMNLLLALNLHLTAPDQNVIMAALSKHTNVKIFSEKLLLLLNRGDDPVRIF 596

  Fly   688 KHPNEHMNTVLRMFIDIFSHPDTAGMFYTNDIKVLIDIVVRQLSDLDAGSTTRPCYLELCRRILR 752
            :|..:..::||:...|:||...||.:||..|:..||||.|||::||..|...|..||.|...::|
  Rat   597 RHEPQPPHSVLKFLQDVFSSAATASIFYHTDMMALIDITVRQIADLSPGDKLRMEYLSLMHAVVR 661

  Fly   753 NTNYQEHQHRKHDLMKIFTRIFCEE---TECSASDQQLVREIANEFPQL 798
            :|.|.:|:||..||.....||..||   .:|. .|:.:|:|:..|||.|
  Rat   662 STPYLQHRHRLSDLQATLRRILTEEETSPQCQ-MDRMIVQEMYKEFPDL 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2258	NP_001285000.1	SH3_SPIN90	1..55	CDD:212783	18/54 (33%)
		PHA03420	108..>188	CDD:177648	18/88 (20%)
		DUF2013	631..766	CDD:286514	56/134 (42%)
Nckipsd	NP_001380856.1	SH3_SPIN90	1..53	CDD:212783	17/53 (32%)
		PRK14965	<223..312	CDD:237871	21/130 (16%)
		DUF2013	<562..675	CDD:401404	49/112 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354597
Domainoid	1	1.000	158	1.000	Domainoid score	I4044
eggNOG	1	0.900	-	-		E1_KOG4035
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2841
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290029at33208
OrthoFinder	1	1.000	-	-		FOG0006257
OrthoInspector	1	1.000	-	-		oto97979
orthoMCL	1	0.900	-	-		OOG6_107366
Panther	1	1.100	-	-	LDO	PTHR13357
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4538
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760